FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994766233> ?p ?o ?g. }

• W2994766233 endingPage "4" @default.
• W2994766233 startingPage "4" @default.
• W2994766233 abstract "Cardiovascular diseases (CVDs) represent a major concern in today’s society, with more than 17.5 million deaths reported annually worldwide. Recently, five metabolites related to the gut metabolism of phospholipids were identified as promising predictive biomarker candidates for CVD. Validation of those biomarker candidates is crucial for applications to the clinic, showing the need for high-throughput analysis of large numbers of samples. These five compounds, trimethylamine N-oxide (TMAO), choline, betaine, l-carnitine, and deoxy-l-carnitine (4-trimethylammoniobutanoic acid), are highly polar compounds and show poor retention on conventional reversed phase chromatography, which can lead to strong matrix effects when using mass spectrometry detection, especially when high-throughput analysis approaches are used with limited separation of analytes from interferences. In order to reduce the potential matrix effects, we propose a novel fast parallel electromembrane extraction (Pa-EME) method for the analysis of these metabolites in plasma samples. The evaluation of Pa-EME parameters was performed using multi segment injection–capillary electrophoresis–mass spectrometry (MSI-CE-MS). Recoveries up to 100% were achieved, with variability as low as 2%. Overall, this study highlights the necessity of protein precipitation prior to EME for the extraction of highly polar compounds. The developed Pa-EME method was evaluated in terms of concentration range and response function, as well as matrix effects using fast-LC-MS/MS. Finally, the developed workflow was compared to conventional sample pre-treatment, i.e., protein precipitation using methanol, and fast-LC-MS/MS. Data show very strong correlations between both workflows, highlighting the great potential of Pa-EME for high-throughput biological applications." @default.
• W2994766233 created "2019-12-26" @default.
• W2994766233 creator A5011999520 @default.
• W2994766233 creator A5013588236 @default.
• W2994766233 creator A5023078632 @default.
• W2994766233 creator A5046583637 @default.
• W2994766233 creator A5053061350 @default.
• W2994766233 creator A5071473009 @default.
• W2994766233 creator A5076255429 @default.
• W2994766233 creator A5077856477 @default.
• W2994766233 date "2019-12-18" @default.
• W2994766233 modified "2023-10-16" @default.
• W2994766233 title "Electromembrane Extraction of Highly Polar Compounds: Analysis of Cardiovascular Biomarkers in Plasma" @default.
• W2994766233 cites W1754198857 @default.
• W2994766233 cites W1954514957 @default.
• W2994766233 cites W1964883031 @default.
• W2994766233 cites W1990160157 @default.
• W2994766233 cites W2006643119 @default.
• W2994766233 cites W2018196344 @default.
• W2994766233 cites W2033391959 @default.
• W2994766233 cites W2035241321 @default.
• W2994766233 cites W2050226999 @default.
• W2994766233 cites W2056944801 @default.
• W2994766233 cites W2062114090 @default.
• W2994766233 cites W2075023376 @default.
• W2994766233 cites W2076096588 @default.
• W2994766233 cites W2078599166 @default.
• W2994766233 cites W2095149622 @default.
• W2994766233 cites W2115944543 @default.
• W2994766233 cites W2128107962 @default.
• W2994766233 cites W2224008359 @default.
• W2994766233 cites W2300897365 @default.
• W2994766233 cites W2318690186 @default.
• W2994766233 cites W2325415461 @default.
• W2994766233 cites W2333253614 @default.
• W2994766233 cites W2346522476 @default.
• W2994766233 cites W2395989979 @default.
• W2994766233 cites W2409933541 @default.
• W2994766233 cites W2412537490 @default.
• W2994766233 cites W2499227793 @default.
• W2994766233 cites W2608988246 @default.
• W2994766233 cites W2614243583 @default.
• W2994766233 cites W2614986146 @default.
• W2994766233 cites W2615472748 @default.
• W2994766233 cites W2764299684 @default.
• W2994766233 cites W2765631660 @default.
• W2994766233 cites W2768785504 @default.
• W2994766233 cites W2781946749 @default.
• W2994766233 cites W2804901207 @default.
• W2994766233 cites W2809071982 @default.
• W2994766233 cites W2898765495 @default.
• W2994766233 cites W2924460871 @default.
• W2994766233 cites W2969540729 @default.
• W2994766233 cites W332595 @default.
• W2994766233 doi "https://doi.org/10.3390/metabo10010004" @default.
• W2994766233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7022788" @default.
• W2994766233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31861366" @default.
• W2994766233 hasPublicationYear "2019" @default.
• W2994766233 type Work @default.
• W2994766233 sameAs 2994766233 @default.
• W2994766233 citedByCount "23" @default.
• W2994766233 countsByYear W29947662332020 @default.
• W2994766233 countsByYear W29947662332021 @default.
• W2994766233 countsByYear W29947662332022 @default.
• W2994766233 countsByYear W29947662332023 @default.
• W2994766233 crossrefType "journal-article" @default.
• W2994766233 hasAuthorship W2994766233A5011999520 @default.
• W2994766233 hasAuthorship W2994766233A5013588236 @default.
• W2994766233 hasAuthorship W2994766233A5023078632 @default.
• W2994766233 hasAuthorship W2994766233A5046583637 @default.
• W2994766233 hasAuthorship W2994766233A5053061350 @default.
• W2994766233 hasAuthorship W2994766233A5071473009 @default.
• W2994766233 hasAuthorship W2994766233A5076255429 @default.
• W2994766233 hasAuthorship W2994766233A5077856477 @default.
• W2994766233 hasBestOaLocation W29947662331 @default.
• W2994766233 hasConcept C10390740 @default.
• W2994766233 hasConcept C104317684 @default.
• W2994766233 hasConcept C124535831 @default.
• W2994766233 hasConcept C162356407 @default.
• W2994766233 hasConcept C185592680 @default.
• W2994766233 hasConcept C2776149385 @default.
• W2994766233 hasConcept C2778435403 @default.
• W2994766233 hasConcept C2778576202 @default.
• W2994766233 hasConcept C2781197716 @default.
• W2994766233 hasConcept C43617362 @default.
• W2994766233 hasConcept C46111723 @default.
• W2994766233 hasConcept C4725764 @default.
• W2994766233 hasConcept C55493867 @default.
• W2994766233 hasConcept C64489805 @default.
• W2994766233 hasConcept C74774607 @default.
• W2994766233 hasConcept C81426234 @default.
• W2994766233 hasConceptScore W2994766233C10390740 @default.
• W2994766233 hasConceptScore W2994766233C104317684 @default.
• W2994766233 hasConceptScore W2994766233C124535831 @default.
• W2994766233 hasConceptScore W2994766233C162356407 @default.
• W2994766233 hasConceptScore W2994766233C185592680 @default.
• W2994766233 hasConceptScore W2994766233C2776149385 @default.
• W2994766233 hasConceptScore W2994766233C2778435403 @default.

• next