FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994770641> ?p ?o ?g. }

• W2994770641 abstract "We previously reported that astrocyte-derived proinflammatory cytokine interleukin (IL)-17A could aggravate neuronal ischemic injuries and strength autophagy both in oxygen-glucose deprivation (OGD)/reoxygenation (R)-treated neurons and peri-infarct region of mice with middle cerebral artery occlusion (MCAO)/reperfusion (R)-simulated ischemic stroke. In this study, the role and molecular mechanism of IL-17A in autophagy were further explored under ischemic condition. We found that exogenous addition of rmIL-17A remarkably (P < 0.001) decreased cell viability, which companying with the increases of LC3 II accumulation (P < 0.05 or 0.01) and Beclin 1 levels (P < 0.05 or 0.001), and reduction of p62 levels (P < 0.01 or 0.001) in OGD/R-treated cortical neurons (n = 6). The levels of P-mTOR (Ser 2448) (P < 0.001) and P-S6 (Ser 240/244) (P < 0.01) significantly decreased without the involvement of Akt, ERK1/2 and AMPK in cortical neurons under rmIL-17A and OGD/R treatments (n = 6). Interestingly, the co-IP analysis exhibited that PP2B and mTOR could be reciprocally immunoprecipitated; and the addition of rmIL-17A increased their interactions, PP2B activities (P < 0.001), P-Src (P < 0.001), and P-PLCγ1 (P < 0.01) levels in OGD/R-treated neurons (n = 6 or 5). The PP2B inhibitor Cyclosporin A blocked the induction of excessive autophagy (P < 0.05 or <0.001) and increased cell viability (P < 0.001) after OGD/R and rmIL-17A treatments (n = 6). In addition, the ICV injection of IL-17A neutralizing mAb could attenuate autophagy levels (P < 0.01 or 0.001, n = 6) and improve neurological functions (P < 0.01 or 0.001, n = 10) of mice after 1 h MCAO/R 24 h or 7 d. These results suggested that IL-17A-mediated excessive autophagy aggravates neuronal ischemic injuries via Src-PP2B-mTOR pathway, and IL-17A neutralization may provide a potential therapeutic effect for ischemic stroke." @default.
• W2994770641 created "2019-12-26" @default.
• W2994770641 creator A5009787820 @default.
• W2994770641 creator A5015894529 @default.
• W2994770641 creator A5049396687 @default.
• W2994770641 creator A5061949032 @default.
• W2994770641 creator A5063089557 @default.
• W2994770641 creator A5072310857 @default.
• W2994770641 creator A5081842390 @default.
• W2994770641 date "2019-12-20" @default.
• W2994770641 modified "2023-10-16" @default.
• W2994770641 title "IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway" @default.
• W2994770641 cites W1505833426 @default.
• W2994770641 cites W1523693806 @default.
• W2994770641 cites W1527349353 @default.
• W2994770641 cites W1541488575 @default.
• W2994770641 cites W1547201740 @default.
• W2994770641 cites W1964680215 @default.
• W2994770641 cites W1969184610 @default.
• W2994770641 cites W1984754431 @default.
• W2994770641 cites W1985027247 @default.
• W2994770641 cites W1986478574 @default.
• W2994770641 cites W1989001365 @default.
• W2994770641 cites W1998682097 @default.
• W2994770641 cites W2012337163 @default.
• W2994770641 cites W2019554063 @default.
• W2994770641 cites W2023590150 @default.
• W2994770641 cites W2024858284 @default.
• W2994770641 cites W2034861293 @default.
• W2994770641 cites W2043939763 @default.
• W2994770641 cites W2045373134 @default.
• W2994770641 cites W2046335099 @default.
• W2994770641 cites W2056504998 @default.
• W2994770641 cites W2065031087 @default.
• W2994770641 cites W2065592028 @default.
• W2994770641 cites W2070168292 @default.
• W2994770641 cites W2085815361 @default.
• W2994770641 cites W2123777737 @default.
• W2994770641 cites W2214456560 @default.
• W2994770641 cites W2275643309 @default.
• W2994770641 cites W2343603404 @default.
• W2994770641 cites W2470092373 @default.
• W2994770641 cites W2485096444 @default.
• W2994770641 cites W2560778142 @default.
• W2994770641 cites W2609219710 @default.
• W2994770641 cites W2737175394 @default.
• W2994770641 cites W2752326209 @default.
• W2994770641 cites W2757753403 @default.
• W2994770641 cites W2773814520 @default.
• W2994770641 cites W2782694212 @default.
• W2994770641 cites W2792707388 @default.
• W2994770641 cites W2793614979 @default.
• W2994770641 cites W2799735211 @default.
• W2994770641 cites W2803958951 @default.
• W2994770641 cites W2805415117 @default.
• W2994770641 cites W2883981538 @default.
• W2994770641 cites W2915066831 @default.
• W2994770641 cites W2922220570 @default.
• W2994770641 cites W2988944836 @default.
• W2994770641 cites W4211247746 @default.
• W2994770641 cites W636081164 @default.
• W2994770641 doi "https://doi.org/10.3389/fimmu.2019.02952" @default.
• W2994770641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6933613" @default.
• W2994770641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31921197" @default.
• W2994770641 hasPublicationYear "2019" @default.
• W2994770641 type Work @default.
• W2994770641 sameAs 2994770641 @default.
• W2994770641 citedByCount "47" @default.
• W2994770641 countsByYear W29947706412020 @default.
• W2994770641 countsByYear W29947706412021 @default.
• W2994770641 countsByYear W29947706412022 @default.
• W2994770641 countsByYear W29947706412023 @default.
• W2994770641 crossrefType "journal-article" @default.
• W2994770641 hasAuthorship W2994770641A5009787820 @default.
• W2994770641 hasAuthorship W2994770641A5015894529 @default.
• W2994770641 hasAuthorship W2994770641A5049396687 @default.
• W2994770641 hasAuthorship W2994770641A5061949032 @default.
• W2994770641 hasAuthorship W2994770641A5063089557 @default.
• W2994770641 hasAuthorship W2994770641A5072310857 @default.
• W2994770641 hasAuthorship W2994770641A5081842390 @default.
• W2994770641 hasBestOaLocation W29947706411 @default.
• W2994770641 hasConcept C11960822 @default.
• W2994770641 hasConcept C126322002 @default.
• W2994770641 hasConcept C134018914 @default.
• W2994770641 hasConcept C164027704 @default.
• W2994770641 hasConcept C185592680 @default.
• W2994770641 hasConcept C190283241 @default.
• W2994770641 hasConcept C203522944 @default.
• W2994770641 hasConcept C2776914184 @default.
• W2994770641 hasConcept C2780124434 @default.
• W2994770641 hasConcept C53227056 @default.
• W2994770641 hasConcept C55493867 @default.
• W2994770641 hasConcept C71924100 @default.
• W2994770641 hasConcept C75217442 @default.
• W2994770641 hasConcept C86554907 @default.
• W2994770641 hasConcept C97029542 @default.
• W2994770641 hasConcept C98274493 @default.
• W2994770641 hasConceptScore W2994770641C11960822 @default.
• W2994770641 hasConceptScore W2994770641C126322002 @default.
• W2994770641 hasConceptScore W2994770641C134018914 @default.

• next