Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994774911> ?p ?o ?g. }
- W2994774911 endingPage "288" @default.
- W2994774911 startingPage "266" @default.
- W2994774911 abstract "Abstract Huntington’s disease is associated with a reactive microglial response and consequent inflammation. To address the role of these cells in disease pathogenesis, we depleted microglia from R6/2 mice, a rapidly progressing model of Huntington’s disease marked by behavioural impairment, mutant huntingtin (mHTT) accumulation, and early death, through colony-stimulating factor 1 receptor inhibition (CSF1Ri) with pexidartinib (PLX3397) for the duration of disease. Although we observed an interferon gene signature in addition to downregulated neuritogenic and synaptic gene pathways with disease, overt inflammation was not evident by microglial morphology or cytokine transcript levels in R6/2 mice. Nonetheless, CSF1Ri-induced microglial elimination reduced or prevented disease-related grip strength and object recognition deficits, mHTT accumulation, astrogliosis, and striatal volume loss, the latter of which was not associated with reductions in cell number but with the extracellular accumulation of chondroitin sulphate proteoglycans (CSPGs)—a primary component of glial scars. A concurrent loss of proteoglycan-containing perineuronal nets was also evident in R6/2 mice, and microglial elimination not only prevented this but also strikingly increased perineuronal nets in the brains of naïve littermates, suggesting a new role for microglia as homeostatic regulators of perineuronal net formation and integrity." @default.
- W2994774911 created "2019-12-26" @default.
- W2994774911 creator A5010098516 @default.
- W2994774911 creator A5028823815 @default.
- W2994774911 creator A5042469087 @default.
- W2994774911 creator A5066725306 @default.
- W2994774911 creator A5071658618 @default.
- W2994774911 creator A5077156090 @default.
- W2994774911 date "2019-12-17" @default.
- W2994774911 modified "2023-10-16" @default.
- W2994774911 title "Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease" @default.
- W2994774911 cites W1025546798 @default.
- W2994774911 cites W1485896673 @default.
- W2994774911 cites W1502625668 @default.
- W2994774911 cites W1521194061 @default.
- W2994774911 cites W1530199299 @default.
- W2994774911 cites W1599327761 @default.
- W2994774911 cites W1701451744 @default.
- W2994774911 cites W1866366362 @default.
- W2994774911 cites W1905860502 @default.
- W2994774911 cites W1920357305 @default.
- W2994774911 cites W1963594713 @default.
- W2994774911 cites W1965301309 @default.
- W2994774911 cites W1965975446 @default.
- W2994774911 cites W1969768014 @default.
- W2994774911 cites W1974897920 @default.
- W2994774911 cites W1975432299 @default.
- W2994774911 cites W1976817344 @default.
- W2994774911 cites W1980789245 @default.
- W2994774911 cites W1984861969 @default.
- W2994774911 cites W1990782693 @default.
- W2994774911 cites W1992898455 @default.
- W2994774911 cites W1994285647 @default.
- W2994774911 cites W2001597502 @default.
- W2994774911 cites W2002147071 @default.
- W2994774911 cites W2003438800 @default.
- W2994774911 cites W2005347777 @default.
- W2994774911 cites W2009110155 @default.
- W2994774911 cites W2012448906 @default.
- W2994774911 cites W2017814058 @default.
- W2994774911 cites W2019971954 @default.
- W2994774911 cites W2025681964 @default.
- W2994774911 cites W2027835288 @default.
- W2994774911 cites W2031096177 @default.
- W2994774911 cites W2034767892 @default.
- W2994774911 cites W2041329915 @default.
- W2994774911 cites W2042737435 @default.
- W2994774911 cites W2048323087 @default.
- W2994774911 cites W2049336648 @default.
- W2994774911 cites W2054275187 @default.
- W2994774911 cites W2055661286 @default.
- W2994774911 cites W2056273928 @default.
- W2994774911 cites W2058953761 @default.
- W2994774911 cites W2060177991 @default.
- W2994774911 cites W2061119206 @default.
- W2994774911 cites W2062682951 @default.
- W2994774911 cites W2063375748 @default.
- W2994774911 cites W2066520425 @default.
- W2994774911 cites W2068275936 @default.
- W2994774911 cites W2069132567 @default.
- W2994774911 cites W2071671447 @default.
- W2994774911 cites W2072133859 @default.
- W2994774911 cites W2073489133 @default.
- W2994774911 cites W2078474557 @default.
- W2994774911 cites W2082938488 @default.
- W2994774911 cites W2083861363 @default.
- W2994774911 cites W2083985795 @default.
- W2994774911 cites W2086085796 @default.
- W2994774911 cites W2094660330 @default.
- W2994774911 cites W2097365950 @default.
- W2994774911 cites W2101108887 @default.
- W2994774911 cites W2104431737 @default.
- W2994774911 cites W2104968232 @default.
- W2994774911 cites W2106708530 @default.
- W2994774911 cites W2107514471 @default.
- W2994774911 cites W2109410754 @default.
- W2994774911 cites W2112406695 @default.
- W2994774911 cites W2114104545 @default.
- W2994774911 cites W2115926962 @default.
- W2994774911 cites W2118546680 @default.
- W2994774911 cites W2121642311 @default.
- W2994774911 cites W2125309982 @default.
- W2994774911 cites W2127079528 @default.
- W2994774911 cites W2127381922 @default.
- W2994774911 cites W2133775329 @default.
- W2994774911 cites W2137288609 @default.
- W2994774911 cites W2140639536 @default.
- W2994774911 cites W2141989757 @default.
- W2994774911 cites W2160748841 @default.
- W2994774911 cites W2169456326 @default.
- W2994774911 cites W2169700519 @default.
- W2994774911 cites W2177948763 @default.
- W2994774911 cites W2190404250 @default.
- W2994774911 cites W2237909979 @default.
- W2994774911 cites W2259139274 @default.
- W2994774911 cites W2267102674 @default.
- W2994774911 cites W2281702574 @default.
- W2994774911 cites W2335534790 @default.