FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994776990> ?p ?o ?g. }

• W2994776990 endingPage "243.e3" @default.
• W2994776990 startingPage "236" @default.
• W2994776990 abstract "RNA-dependent NTPases can act as RNA/RNA-protein remodeling enzymes and typically exhibit low NTPase activity in the absence of RNA/RNA-protein substrates. How futile intrinsic NTP hydrolysis is prevented is frequently not known. The ATPase/RNA helicase Brr2 belongs to the Ski2-like family of nucleic acid-dependent NTPases and is an integral component of the spliceosome. Comprehensive nucleotide binding and hydrolysis studies are not available for a member of the Ski2-like family. We present crystal structures of Chaetomium thermophilum Brr2 in the apo, ADP-bound, and ATPγS-bound states, revealing nucleotide-induced conformational changes and a hitherto unknown ATPγS binding mode. Our results in conjunction with Brr2 structures in other molecular contexts reveal multiple molecular mechanisms that contribute to the inhibition of intrinsic ATPase activity, including an N-terminal region that restrains the RecA-like domains in an open conformation and exclusion of an attacking water molecule, and suggest how RNA substrate binding can lead to ATPase stimulation." @default.
• W2994776990 created "2019-12-26" @default.
• W2994776990 creator A5012758202 @default.
• W2994776990 creator A5025787259 @default.
• W2994776990 creator A5052692229 @default.
• W2994776990 date "2020-02-01" @default.
• W2994776990 modified "2023-10-17" @default.
• W2994776990 title "Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase" @default.
• W2994776990 cites W1743689021 @default.
• W2994776990 cites W1979491817 @default.
• W2994776990 cites W1979564291 @default.
• W2994776990 cites W1996904671 @default.
• W2994776990 cites W2001130038 @default.
• W2994776990 cites W2017866593 @default.
• W2994776990 cites W2036764180 @default.
• W2994776990 cites W2036842869 @default.
• W2994776990 cites W2037978116 @default.
• W2994776990 cites W2057990302 @default.
• W2994776990 cites W2076992915 @default.
• W2994776990 cites W2077833583 @default.
• W2994776990 cites W2078532539 @default.
• W2994776990 cites W2083520043 @default.
• W2994776990 cites W2086124878 @default.
• W2994776990 cites W2105439835 @default.
• W2994776990 cites W2108921801 @default.
• W2994776990 cites W2109184569 @default.
• W2994776990 cites W2112016696 @default.
• W2994776990 cites W2122867782 @default.
• W2994776990 cites W2124026197 @default.
• W2994776990 cites W2129195166 @default.
• W2994776990 cites W2136058787 @default.
• W2994776990 cites W2136311011 @default.
• W2994776990 cites W2154197653 @default.
• W2994776990 cites W2154714625 @default.
• W2994776990 cites W2163341755 @default.
• W2994776990 cites W2166288313 @default.
• W2994776990 cites W2185816073 @default.
• W2994776990 cites W2210120548 @default.
• W2994776990 cites W2225521622 @default.
• W2994776990 cites W2259134357 @default.
• W2994776990 cites W2287289125 @default.
• W2994776990 cites W2556365263 @default.
• W2994776990 cites W2578197308 @default.
• W2994776990 cites W2621629555 @default.
• W2994776990 cites W2744206279 @default.
• W2994776990 cites W2807644316 @default.
• W2994776990 cites W2846099848 @default.
• W2994776990 cites W4247076899 @default.
• W2994776990 cites W4248872320 @default.
• W2994776990 cites W4254324080 @default.
• W2994776990 doi "https://doi.org/10.1016/j.str.2019.11.014" @default.
• W2994776990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31859026" @default.
• W2994776990 hasPublicationYear "2020" @default.
• W2994776990 type Work @default.
• W2994776990 sameAs 2994776990 @default.
• W2994776990 citedByCount "12" @default.
• W2994776990 countsByYear W29947769902020 @default.
• W2994776990 countsByYear W29947769902021 @default.
• W2994776990 countsByYear W29947769902022 @default.
• W2994776990 countsByYear W29947769902023 @default.
• W2994776990 crossrefType "journal-article" @default.
• W2994776990 hasAuthorship W2994776990A5012758202 @default.
• W2994776990 hasAuthorship W2994776990A5025787259 @default.
• W2994776990 hasAuthorship W2994776990A5052692229 @default.
• W2994776990 hasBestOaLocation W29947769901 @default.
• W2994776990 hasConcept C104317684 @default.
• W2994776990 hasConcept C12554922 @default.
• W2994776990 hasConcept C141315368 @default.
• W2994776990 hasConcept C161223559 @default.
• W2994776990 hasConcept C181199279 @default.
• W2994776990 hasConcept C185592680 @default.
• W2994776990 hasConcept C194993378 @default.
• W2994776990 hasConcept C23265538 @default.
• W2994776990 hasConcept C24107716 @default.
• W2994776990 hasConcept C40000846 @default.
• W2994776990 hasConcept C42369531 @default.
• W2994776990 hasConcept C512185932 @default.
• W2994776990 hasConcept C54458228 @default.
• W2994776990 hasConcept C55493867 @default.
• W2994776990 hasConcept C67705224 @default.
• W2994776990 hasConcept C68592252 @default.
• W2994776990 hasConcept C86803240 @default.
• W2994776990 hasConcept C95444343 @default.
• W2994776990 hasConceptScore W2994776990C104317684 @default.
• W2994776990 hasConceptScore W2994776990C12554922 @default.
• W2994776990 hasConceptScore W2994776990C141315368 @default.
• W2994776990 hasConceptScore W2994776990C161223559 @default.
• W2994776990 hasConceptScore W2994776990C181199279 @default.
• W2994776990 hasConceptScore W2994776990C185592680 @default.
• W2994776990 hasConceptScore W2994776990C194993378 @default.
• W2994776990 hasConceptScore W2994776990C23265538 @default.
• W2994776990 hasConceptScore W2994776990C24107716 @default.
• W2994776990 hasConceptScore W2994776990C40000846 @default.
• W2994776990 hasConceptScore W2994776990C42369531 @default.
• W2994776990 hasConceptScore W2994776990C512185932 @default.
• W2994776990 hasConceptScore W2994776990C54458228 @default.
• W2994776990 hasConceptScore W2994776990C55493867 @default.
• W2994776990 hasConceptScore W2994776990C67705224 @default.

• next