Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994793828> ?p ?o ?g. }
- W2994793828 endingPage "1355" @default.
- W2994793828 startingPage "1345" @default.
- W2994793828 abstract "Oral preexposure prophylaxis (PrEP) in the form of tenofovir-disoproxil-fumarate/emtricitabine is being implemented in selected sites in South Africa. Addressing outstanding questions on PrEP cost-effectiveness can inform further implementation.We calibrated an individual-based model to KwaZulu-Natal to predict the impact and cost-effectiveness of PrEP, with use concentrated in periods of condomless sex, accounting for effects on drug resistance. We consider (1) PrEP availability for adolescent girls and young women aged 15-24 years and female sex workers, and (2) availability for everyone aged 15-64 years. Our primary analysis represents a level of PrEP use hypothesized to be attainable by future PrEP programs.In the context of PrEP use in adults aged 15-64 years, there was a predicted 33% reduction in incidence and 36% reduction in women aged 15-24 years. PrEP was cost-effective, including in a range of sensitivity analyses, although with substantially reduced (cost) effectiveness under a policy of ART initiation with efavirenz- rather than dolutegravir-based regimens due to PrEP undermining ART effectiveness by increasing HIV drug resistance.PrEP use concentrated during time periods of condomless sex has the potential to substantively impact HIV incidence and be cost-effective." @default.
- W2994793828 created "2019-12-26" @default.
- W2994793828 creator A5004174170 @default.
- W2994793828 creator A5004888091 @default.
- W2994793828 creator A5007640655 @default.
- W2994793828 creator A5010363476 @default.
- W2994793828 creator A5016768242 @default.
- W2994793828 creator A5017336802 @default.
- W2994793828 creator A5025775220 @default.
- W2994793828 creator A5026481326 @default.
- W2994793828 creator A5030670576 @default.
- W2994793828 creator A5031952967 @default.
- W2994793828 creator A5033521226 @default.
- W2994793828 creator A5036022502 @default.
- W2994793828 creator A5038307269 @default.
- W2994793828 creator A5042459578 @default.
- W2994793828 creator A5043916447 @default.
- W2994793828 creator A5052776114 @default.
- W2994793828 creator A5067119594 @default.
- W2994793828 creator A5068458100 @default.
- W2994793828 creator A5089446248 @default.
- W2994793828 date "2019-12-18" @default.
- W2994793828 modified "2023-10-14" @default.
- W2994793828 title "Potential Impact and Cost-Effectiveness of Condomless-Sex–Concentrated PrEP in KwaZulu-Natal Accounting for Drug Resistance" @default.
- W2994793828 cites W1976028120 @default.
- W2994793828 cites W1991541076 @default.
- W2994793828 cites W2009115424 @default.
- W2994793828 cites W2021682988 @default.
- W2994793828 cites W2029036450 @default.
- W2994793828 cites W2060928941 @default.
- W2994793828 cites W2065159982 @default.
- W2994793828 cites W2065719742 @default.
- W2994793828 cites W2068081534 @default.
- W2994793828 cites W2080988445 @default.
- W2994793828 cites W2104078551 @default.
- W2994793828 cites W2117057469 @default.
- W2994793828 cites W2123519394 @default.
- W2994793828 cites W2126401413 @default.
- W2994793828 cites W2143731718 @default.
- W2994793828 cites W2154854455 @default.
- W2994793828 cites W2157921853 @default.
- W2994793828 cites W2162226934 @default.
- W2994793828 cites W2286756681 @default.
- W2994793828 cites W2319917590 @default.
- W2994793828 cites W2402018016 @default.
- W2994793828 cites W2462213043 @default.
- W2994793828 cites W2534106828 @default.
- W2994793828 cites W2583221584 @default.
- W2994793828 cites W2593867344 @default.
- W2994793828 cites W2740371432 @default.
- W2994793828 cites W2761592537 @default.
- W2994793828 cites W2763419945 @default.
- W2994793828 cites W2768299619 @default.
- W2994793828 cites W2769909914 @default.
- W2994793828 cites W2772297987 @default.
- W2994793828 cites W2790936048 @default.
- W2994793828 cites W2800724979 @default.
- W2994793828 cites W2884876183 @default.
- W2994793828 cites W2897190201 @default.
- W2994793828 cites W2902025352 @default.
- W2994793828 doi "https://doi.org/10.1093/infdis/jiz667" @default.
- W2994793828 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8064039" @default.
- W2994793828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31851759" @default.
- W2994793828 hasPublicationYear "2019" @default.
- W2994793828 type Work @default.
- W2994793828 sameAs 2994793828 @default.
- W2994793828 citedByCount "17" @default.
- W2994793828 countsByYear W29947938282020 @default.
- W2994793828 countsByYear W29947938282021 @default.
- W2994793828 countsByYear W29947938282022 @default.
- W2994793828 countsByYear W29947938282023 @default.
- W2994793828 crossrefType "journal-article" @default.
- W2994793828 hasAuthorship W2994793828A5004174170 @default.
- W2994793828 hasAuthorship W2994793828A5004888091 @default.
- W2994793828 hasAuthorship W2994793828A5007640655 @default.
- W2994793828 hasAuthorship W2994793828A5010363476 @default.
- W2994793828 hasAuthorship W2994793828A5016768242 @default.
- W2994793828 hasAuthorship W2994793828A5017336802 @default.
- W2994793828 hasAuthorship W2994793828A5025775220 @default.
- W2994793828 hasAuthorship W2994793828A5026481326 @default.
- W2994793828 hasAuthorship W2994793828A5030670576 @default.
- W2994793828 hasAuthorship W2994793828A5031952967 @default.
- W2994793828 hasAuthorship W2994793828A5033521226 @default.
- W2994793828 hasAuthorship W2994793828A5036022502 @default.
- W2994793828 hasAuthorship W2994793828A5038307269 @default.
- W2994793828 hasAuthorship W2994793828A5042459578 @default.
- W2994793828 hasAuthorship W2994793828A5043916447 @default.
- W2994793828 hasAuthorship W2994793828A5052776114 @default.
- W2994793828 hasAuthorship W2994793828A5067119594 @default.
- W2994793828 hasAuthorship W2994793828A5068458100 @default.
- W2994793828 hasAuthorship W2994793828A5089446248 @default.
- W2994793828 hasBestOaLocation W29947938281 @default.
- W2994793828 hasConcept C120665830 @default.
- W2994793828 hasConcept C121332964 @default.
- W2994793828 hasConcept C142462285 @default.
- W2994793828 hasConcept C144024400 @default.
- W2994793828 hasConcept C149923435 @default.
- W2994793828 hasConcept C151730666 @default.