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• W2994804311 endingPage "108322" @default.
• W2994804311 startingPage "108322" @default.
• W2994804311 abstract "Adiponectin is downregulated in obesity negatively impacting the thermogenesis and impairing white fat browning. Despite the notable effects of green tea (GT) extract in the enhancement of thermogenesis, if its effects are being mediated by adiponectin has been scarcely explored. For this purpose, we investigated the role of adiponectin in the thermogenic actions of GT extract by using an adiponectin-knockout mice model. Male wild-type (WT) and knockout (AdipoKO) C57Bl/6 mice (3 months) were divided into 6 groups: mice fed a standard diet+gavage with water (SD WT, and SD AdipoKO), high-fat diet (HFD)+gavage with water (HFD WT, and HFD AdipoKO), and HFD + gavage with 500 mg/kg of body weight (BW) of GT extract (HFD + GT WT, and HFD + GT AdipoKO). After 20 weeks of experimentation, mice were euthanized and adipose tissue was properly removed. Our findings indicate that treatment with GT extract reversed complications of obesity in WT mice by decreasing final BW gain, adiposity index, adipocyte size and insulin resistance (IR). However, the action of the GT extract was not effective in reversing those markers in the AdipoKO mice, although GT acts independently in the reversal of IR. GT-treatment induced enhancement in energy expenditure (EE), BAT thermogenesis, and promoted browning phenotype in the subcutaneous WAT (scWAT) of WT mice. On the other hand, the thermogenic program was markedly impaired in BAT and scWAT of AdipoKO mice. Our outcomes unveiled adiponectin as a key direct signal for GT extract inducing adaptive thermogenesis and browning in scWAT." @default.
• W2994804311 created "2019-12-26" @default.
• W2994804311 creator A5006242477 @default.
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• W2994804311 date "2020-04-01" @default.
• W2994804311 modified "2023-09-26" @default.
• W2994804311 title "Polyphenol-rich green tea extract induces thermogenesis in mice by a mechanism dependent on adiponectin signaling" @default.
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• W2994804311 doi "https://doi.org/10.1016/j.jnutbio.2019.108322" @default.
• W2994804311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32120266" @default.
• W2994804311 hasPublicationYear "2020" @default.
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