FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994815250> ?p ?o ?g. }

• W2994815250 abstract "In the cell, protein folding begins during protein synthesis/translation and thus is a co-translational process. Co-translational protein folding is tightly linked to translation elongation, which is not a uniform process. While there are many reasons for translation non-uniformity, it is generally believed that non-uniform synonymous codon usage is one of the key factors modulating translation elongation rates. Frequent/optimal codons as a rule are translated more rapidly than infrequently used ones and vice versa. Over 30 years ago, it was hypothesized that changes in synonymous codon usage affecting translation elongation rates could impinge on co-translation protein folding and that many synonymous codons are strategically placed within mRNA to ensure a particular translation kinetics facilitating productive step-by-step co-translational folding of proteins. It was suggested that this particular translation kinetics (and, specifically, translation pause sites) may define the window of opportunity for the protein parts to fold locally, particularly at the critical points where folding is far from equilibrium. It was thus hypothesized that synonymous codons may provide a secondary code for protein folding in the cell. Although, mostly accepted now, this hypothesis appeared to be difficult to prove and many convincing results were obtained only relatively recently. Here, I review the progress in the field and explain, why this simple idea appeared to be so challenging to prove." @default.
• W2994815250 created "2019-12-26" @default.
• W2994815250 creator A5025432010 @default.
• W2994815250 date "2019-01-01" @default.
• W2994815250 modified "2023-10-14" @default.
• W2994815250 title "Распределение синонимических кодонов в мРНК определяет путь котрансляционного сворачивания белка в клетке" @default.
• W2994815250 cites W1509638340 @default.
• W2994815250 cites W1509905456 @default.
• W2994815250 cites W1539491410 @default.
• W2994815250 cites W1539868719 @default.
• W2994815250 cites W1544393375 @default.
• W2994815250 cites W1550695177 @default.
• W2994815250 cites W1570539079 @default.
• W2994815250 cites W1589192533 @default.
• W2994815250 cites W1658462258 @default.
• W2994815250 cites W1777817130 @default.
• W2994815250 cites W1794440115 @default.
• W2994815250 cites W1799375255 @default.
• W2994815250 cites W1956613997 @default.
• W2994815250 cites W1965352738 @default.
• W2994815250 cites W1968654669 @default.
• W2994815250 cites W1972663311 @default.
• W2994815250 cites W1974333371 @default.
• W2994815250 cites W1974358663 @default.
• W2994815250 cites W1974557906 @default.
• W2994815250 cites W1975419420 @default.
• W2994815250 cites W1980676977 @default.
• W2994815250 cites W1984512854 @default.
• W2994815250 cites W1986720579 @default.
• W2994815250 cites W1999177695 @default.
• W2994815250 cites W1999534036 @default.
• W2994815250 cites W2002677631 @default.
• W2994815250 cites W2002999243 @default.
• W2994815250 cites W2008365039 @default.
• W2994815250 cites W2011205484 @default.
• W2994815250 cites W2013321787 @default.
• W2994815250 cites W2018590530 @default.
• W2994815250 cites W2021615882 @default.
• W2994815250 cites W2022726657 @default.
• W2994815250 cites W2028007013 @default.
• W2994815250 cites W2028740753 @default.
• W2994815250 cites W2030205072 @default.
• W2994815250 cites W2030899314 @default.
• W2994815250 cites W2034456045 @default.
• W2994815250 cites W2035475950 @default.
• W2994815250 cites W2035792964 @default.
• W2994815250 cites W2035945428 @default.
• W2994815250 cites W2037611736 @default.
• W2994815250 cites W2039911942 @default.
• W2994815250 cites W2045391589 @default.
• W2994815250 cites W2045777307 @default.
• W2994815250 cites W2047590148 @default.
• W2994815250 cites W2047744572 @default.
• W2994815250 cites W2049576347 @default.
• W2994815250 cites W2049811388 @default.
• W2994815250 cites W2051043527 @default.
• W2994815250 cites W2051242197 @default.
• W2994815250 cites W2052413864 @default.
• W2994815250 cites W2055536178 @default.
• W2994815250 cites W2056029668 @default.
• W2994815250 cites W2057097492 @default.
• W2994815250 cites W2058864686 @default.
• W2994815250 cites W2060481089 @default.
• W2994815250 cites W2063504601 @default.
• W2994815250 cites W2065248572 @default.
• W2994815250 cites W2065671146 @default.
• W2994815250 cites W2069384750 @default.
• W2994815250 cites W2072499238 @default.
• W2994815250 cites W2073501728 @default.
• W2994815250 cites W2076034830 @default.
• W2994815250 cites W2076793571 @default.
• W2994815250 cites W2078010704 @default.
• W2994815250 cites W2079517684 @default.
• W2994815250 cites W2081860615 @default.
• W2994815250 cites W2082657939 @default.
• W2994815250 cites W2085522899 @default.
• W2994815250 cites W2085717111 @default.
• W2994815250 cites W2087461762 @default.
• W2994815250 cites W2091411115 @default.
• W2994815250 cites W2092042958 @default.
• W2994815250 cites W2094338137 @default.
• W2994815250 cites W2097248196 @default.
• W2994815250 cites W2116541947 @default.
• W2994815250 cites W2122360938 @default.
• W2994815250 cites W2127161280 @default.
• W2994815250 cites W2127303081 @default.
• W2994815250 cites W2127435852 @default.
• W2994815250 cites W2138721124 @default.
• W2994815250 cites W2139839186 @default.
• W2994815250 cites W2140127479 @default.
• W2994815250 cites W2143292066 @default.
• W2994815250 cites W2145203699 @default.
• W2994815250 cites W2148734328 @default.
• W2994815250 cites W2149424410 @default.
• W2994815250 cites W2151373788 @default.
• W2994815250 cites W2154232977 @default.
• W2994815250 cites W2157613837 @default.
• W2994815250 cites W2157913328 @default.
• W2994815250 cites W2164618276 @default.
• W2994815250 cites W2164696877 @default.

• next