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• W2994820341 endingPage "158591" @default.
• W2994820341 startingPage "158591" @default.
• W2994820341 abstract "Vitamin A is an essential nutrient, critical for proper embryonic development in mammals. Both embryonic vitamin A-deficiency or -excess lead to congenital malformations or lethality in mammals, including humans. This is due to the defective transcriptional action of retinoic acid, the active form of vitamin A, that regulates in a spatial- and temporal-dependent manner the expression of genes essential for organogenesis. Thus, an adequate supply of vitamin A from the maternal circulation is vital for normal mammalian fetal development. Provitamin A carotenoids circulate in the maternal bloodstream and are available to the embryo. Of all the dietary carotenoids, β-carotene is the main vitamin A precursor, contributing at least 30% of the vitamin A intake in the industrialized countries and often constituting the sole source of retinoids (vitamin A and its derivatives) in the developing world. In humans, up to 40% of the absorbed dietary β-carotene is incorporated in its intact form in chylomicrons for distribution to other organs within the body, including the developing tissues. Here, it can serve as a source of vitamin A upon conversion into apocarotenoids by its cleavage enzymes. Given that β-carotene is carried in the bloodstream by lipoproteins, and that the placenta acquires, assembles and secretes lipoproteins, it is becoming evident that the maternal-fetal transfer of β-carotene relies on lipoprotein metabolism. Here, we will explore the current knowledge about this important biological process, the cross-talk between carotenoid and lipid metabolism in the context of the maternal-fetal transfer of this provitamin A precursor, and the mechanisms whereby β-carotene is metabolized by the developing tissues. This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro." @default.
• W2994820341 created "2019-12-26" @default.
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• W2994820341 date "2020-11-01" @default.
• W2994820341 modified "2023-10-06" @default.
• W2994820341 title "Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier" @default.
• W2994820341 cites W1224318197 @default.
• W2994820341 cites W1523369023 @default.
• W2994820341 cites W1559887418 @default.
• W2994820341 cites W1560831350 @default.
• W2994820341 cites W1615916252 @default.
• W2994820341 cites W1869365701 @default.
• W2994820341 cites W1900037177 @default.
• W2994820341 cites W1903300978 @default.
• W2994820341 cites W1928884554 @default.
• W2994820341 cites W1942254574 @default.
• W2994820341 cites W1964890275 @default.
• W2994820341 cites W1968086336 @default.
• W2994820341 cites W1968702156 @default.
• W2994820341 cites W1972348965 @default.
• W2994820341 cites W1979652806 @default.
• W2994820341 cites W1979989777 @default.
• W2994820341 cites W1985774463 @default.
• W2994820341 cites W1986962805 @default.
• W2994820341 cites W1994633217 @default.
• W2994820341 cites W1995191011 @default.
• W2994820341 cites W1999446842 @default.
• W2994820341 cites W1999741124 @default.
• W2994820341 cites W2001025469 @default.
• W2994820341 cites W2005554016 @default.
• W2994820341 cites W2012675392 @default.
• W2994820341 cites W2017293137 @default.
• W2994820341 cites W2023712294 @default.
• W2994820341 cites W2028272335 @default.
• W2994820341 cites W2029522112 @default.
• W2994820341 cites W2031946542 @default.
• W2994820341 cites W2033166149 @default.
• W2994820341 cites W2033823655 @default.
• W2994820341 cites W2034067112 @default.
• W2994820341 cites W2041398886 @default.
• W2994820341 cites W2042581920 @default.
• W2994820341 cites W2043748634 @default.
• W2994820341 cites W2045624969 @default.
• W2994820341 cites W2046516643 @default.
• W2994820341 cites W2059591367 @default.
• W2994820341 cites W2060921414 @default.
• W2994820341 cites W2066483255 @default.
• W2994820341 cites W2068902736 @default.
• W2994820341 cites W2070276161 @default.
• W2994820341 cites W2072253833 @default.
• W2994820341 cites W2073241389 @default.
• W2994820341 cites W2073459028 @default.
• W2994820341 cites W2077096051 @default.
• W2994820341 cites W2077334192 @default.
• W2994820341 cites W2083028996 @default.
• W2994820341 cites W2085341432 @default.
• W2994820341 cites W2085391061 @default.
• W2994820341 cites W2087116846 @default.
• W2994820341 cites W2101994946 @default.
• W2994820341 cites W2103591522 @default.
• W2994820341 cites W2108732045 @default.
• W2994820341 cites W2109409295 @default.
• W2994820341 cites W2110122595 @default.
• W2994820341 cites W2110236942 @default.
• W2994820341 cites W2115592253 @default.
• W2994820341 cites W2119194983 @default.
• W2994820341 cites W2119238945 @default.
• W2994820341 cites W2119270583 @default.
• W2994820341 cites W2120177943 @default.
• W2994820341 cites W2121472728 @default.
• W2994820341 cites W2128746061 @default.
• W2994820341 cites W2137823234 @default.
• W2994820341 cites W2144264206 @default.
• W2994820341 cites W2144548956 @default.
• W2994820341 cites W2144830748 @default.
• W2994820341 cites W2146424120 @default.
• W2994820341 cites W2147547208 @default.
• W2994820341 cites W2150937837 @default.
• W2994820341 cites W2153180188 @default.
• W2994820341 cites W2153537151 @default.
• W2994820341 cites W2165699456 @default.
• W2994820341 cites W2165802855 @default.
• W2994820341 cites W2168227380 @default.
• W2994820341 cites W2312944199 @default.
• W2994820341 cites W2345426343 @default.
• W2994820341 cites W2419084840 @default.
• W2994820341 cites W2462411645 @default.
• W2994820341 cites W2472945161 @default.
• W2994820341 cites W2498248523 @default.
• W2994820341 cites W2526822722 @default.
• W2994820341 cites W2551241918 @default.

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