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• W2994825595 abstract "The basal body in the human parasite Trypanosoma brucei is structurally equivalent to the centriole in animals and functions in the nucleation of axonemal microtubules in the flagellum. T. brucei lacks many evolutionarily conserved centriolar protein homologs and constructs the basal body through unknown mechanisms. Two evolutionarily conserved centriole/basal body cartwheel proteins, TbSAS-6 and TbBLD10, and a trypanosome-specific protein, BBP65, play essential roles in basal body biogenesis in T. brucei , but how they cooperate in the regulation of basal body assembly remains elusive. Here using RNAi, endogenous epitope tagging, immunofluorescence microscopy, and 3D-structured illumination super-resolution microscopy, we identified a new trypanosome-specific protein named BBP164 and found that it has an essential role in basal body biogenesis in T. brucei . Further investigation of the functional interplay among BBP164 and the other three regulators of basal body assembly revealed that BBP164 and BBP65 are interdependent for maintaining their stability and depend on TbSAS-6 and TbBLD10 for their stabilization in the basal body. Additionally, TbSAS-6 and TbBLD10 are independent from each other and from BBP164 and BBP65 for maintaining their stability in the basal body. These findings demonstrate that basal body cartwheel proteins are required for stabilizing other basal body components and uncover that regulation of protein stability is an unusual control mechanism for assembly of the basal body in T. brucei ." @default.
• W2994825595 created "2019-12-26" @default.
• W2994825595 creator A5013109261 @default.
• W2994825595 creator A5033187177 @default.
• W2994825595 date "2019-12-09" @default.
• W2994825595 modified "2023-10-13" @default.
• W2994825595 title "Regulated protein stabilization underpins the functional interplay among basal body components in Trypanosoma brucei" @default.
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• W2994825595 doi "https://doi.org/10.1074/jbc.ra119.011352" @default.
• W2994825595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6970926" @default.
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