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- W2994831114 abstract "Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive and vasodilative processes in the pulmonary circulation, pulmonary vasoconstriction, vascular and right ventricular remodeling, systemic inflammation, and autonomic imbalance, with a reduced parasympathetic and increased sympathetic tone. Current pharmacological treatments for PAH include several classes of drugs that target signaling pathways in vascular biology and cardiovascular physiology, but they can have severe unwanted effects and they do not typically stop the progression of the disease. Pulmonary artery denervation has been tested clinically as a method to suppress sympathetic overactivation, however it is a nonspecific and irreversible intervention. Bioelectronic medicine, in particular vagus nerve stimulation (VNS), has been used in cardiovascular disorders like arrhythmias, heart failure and arterial hypertension and could, in principle, be tested as a treatment in PAH. VNS can produce pulmonary vasodilation and renormalize right ventricular function, via activation of pulmonary and cardiac vagal fibers. It can suppress systemic inflammation, via activation of fibers that innervate the spleen. Finally, VNS can gradually restore the balance between parasympathetic and sympathetic tone by regulating autonomic reflexes. Preclinical studies support the feasibility of using VNS in PAH. However, there are challenges with such an approach, arising from the need to affect a relatively small number of relevant vagal fibers, and the potential for unwanted cardiac and noncardiac effects of VNS in this sensitive patient population." @default.
- W2994831114 created "2019-12-26" @default.
- W2994831114 creator A5016254801 @default.
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- W2994831114 date "2019-12-01" @default.
- W2994831114 modified "2023-10-13" @default.
- W2994831114 title "Pulmonary arterial hypertension: the case for a bioelectronic treatment" @default.
- W2994831114 cites W114168622 @default.
- W2994831114 cites W121343895 @default.
- W2994831114 cites W1573321446 @default.
- W2994831114 cites W1603299384 @default.
- W2994831114 cites W1606441445 @default.
- W2994831114 cites W1840736932 @default.
- W2994831114 cites W1880766011 @default.
- W2994831114 cites W1926326792 @default.
- W2994831114 cites W1929000169 @default.
- W2994831114 cites W1970214664 @default.
- W2994831114 cites W1974046929 @default.
- W2994831114 cites W1974172485 @default.
- W2994831114 cites W1974227996 @default.
- W2994831114 cites W1977622983 @default.
- W2994831114 cites W1978319424 @default.
- W2994831114 cites W1979770196 @default.
- W2994831114 cites W1979969712 @default.
- W2994831114 cites W1979975360 @default.
- W2994831114 cites W1987823225 @default.
- W2994831114 cites W1992905803 @default.
- W2994831114 cites W1993217174 @default.
- W2994831114 cites W1996588278 @default.
- W2994831114 cites W1997713908 @default.
- W2994831114 cites W1999516360 @default.
- W2994831114 cites W2000314052 @default.
- W2994831114 cites W2000902819 @default.
- W2994831114 cites W2002797282 @default.
- W2994831114 cites W2002960348 @default.
- W2994831114 cites W2002989725 @default.
- W2994831114 cites W2010171666 @default.
- W2994831114 cites W2013634899 @default.
- W2994831114 cites W2014195246 @default.
- W2994831114 cites W2018124947 @default.
- W2994831114 cites W2022925347 @default.
- W2994831114 cites W2023455251 @default.
- W2994831114 cites W2025717255 @default.
- W2994831114 cites W2027227731 @default.
- W2994831114 cites W2028171556 @default.
- W2994831114 cites W2029399343 @default.
- W2994831114 cites W2035384054 @default.
- W2994831114 cites W2036199559 @default.
- W2994831114 cites W2036642110 @default.
- W2994831114 cites W2039933618 @default.
- W2994831114 cites W2044010537 @default.
- W2994831114 cites W2045199577 @default.
- W2994831114 cites W2046637170 @default.
- W2994831114 cites W2048443661 @default.
- W2994831114 cites W2049176713 @default.
- W2994831114 cites W2051069436 @default.
- W2994831114 cites W2059597936 @default.
- W2994831114 cites W2060718012 @default.
- W2994831114 cites W2063690694 @default.
- W2994831114 cites W2069368135 @default.
- W2994831114 cites W2072349972 @default.
- W2994831114 cites W2072719339 @default.
- W2994831114 cites W2079580389 @default.
- W2994831114 cites W2090213540 @default.
- W2994831114 cites W2091608449 @default.
- W2994831114 cites W2091965408 @default.
- W2994831114 cites W2092352619 @default.
- W2994831114 cites W2097578125 @default.
- W2994831114 cites W2100123523 @default.
- W2994831114 cites W2101386214 @default.
- W2994831114 cites W2101768152 @default.
- W2994831114 cites W2103380294 @default.
- W2994831114 cites W2103596313 @default.
- W2994831114 cites W2105250202 @default.
- W2994831114 cites W2106199142 @default.
- W2994831114 cites W2106521635 @default.
- W2994831114 cites W2107011819 @default.
- W2994831114 cites W2109070559 @default.
- W2994831114 cites W2109333892 @default.
- W2994831114 cites W2112229901 @default.
- W2994831114 cites W2114042807 @default.
- W2994831114 cites W2116095873 @default.
- W2994831114 cites W2116358818 @default.
- W2994831114 cites W2120139621 @default.
- W2994831114 cites W2121376498 @default.
- W2994831114 cites W2122425344 @default.
- W2994831114 cites W2122677936 @default.
- W2994831114 cites W2125263078 @default.
- W2994831114 cites W2126955955 @default.
- W2994831114 cites W2127083673 @default.
- W2994831114 cites W2132001965 @default.
- W2994831114 cites W2132587013 @default.
- W2994831114 cites W2133127623 @default.
- W2994831114 cites W2135510321 @default.
- W2994831114 cites W2137779787 @default.
- W2994831114 cites W2139954704 @default.