FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994833118> ?p ?o ?g. }

• W2994833118 endingPage "248" @default.
• W2994833118 startingPage "238" @default.
• W2994833118 abstract "Methamphetamine (MA) triggers neuroinflammation and medications that counteract MA-induced neuroinflammation may reduce MA-induced neurodegeneration and improve neurocognition and treatment outcomes in MA use disorder. We performed a randomized, placebo-controlled trial to determine the safety and efficacy of ibudilast (IBUD), a phosphodiesterase inhibitor that reduces neuroinflammation, for the treatment of MA use disorder. Treatment-seeking volunteers with MA use disorder were randomly assigned to receive 12 weeks of IBUD 50 mg twice daily (N = 64) or placebo (N = 61) with medication management counseling. Participants visited the outpatient research clinic twice weekly to provide urine specimens for drug screens and undergo study assessments. The primary outcome was end of treatment MA-abstinence (EOTA) during weeks 11 and 12 of treatment. Serum IBUID levels were measured for IBUD participants during week 3 of treatment. There was no difference in EOTA for IBUD (14%) versus placebo (16%, p > 0.05). There was no correlation between serum IBUD levels and MA use during treatment and mean IBUD levels for participants with (mean = 51.3, SD = 20.3) and without (mean = 54.7, SD = 33.0, p = 0.70) EOTA. IBUD was well tolerated. IBUD did not facilitate MA abstinence in this outpatient trial. Whether targeting neuroinflammation, either with IBUD in other subgroups of MA users or clinical trial designs, or with other anti-inflammatory medications, is an effective strategy for treating MA use disorder is not clear. Graphical Abstract The proportion of urine drug screens negative for methamphetamine (MA) during the two week lead-in period (weeks -2 and - 1) and the 12 week medication treatment period (weeks 1-12) for ibudilast versus placebo." @default.
• W2994833118 created "2019-12-26" @default.
• W2994833118 creator A5009963710 @default.
• W2994833118 creator A5042765290 @default.
• W2994833118 creator A5059477293 @default.
• W2994833118 creator A5059600880 @default.
• W2994833118 creator A5063288618 @default.
• W2994833118 creator A5068139431 @default.
• W2994833118 creator A5079506325 @default.
• W2994833118 date "2019-12-09" @default.
• W2994833118 modified "2023-10-17" @default.
• W2994833118 title "Randomized, Placebo-Controlled Trial of Targeting Neuroinflammation with Ibudilast to Treat Methamphetamine Use Disorder" @default.
• W2994833118 cites W1483496794 @default.
• W2994833118 cites W1542501108 @default.
• W2994833118 cites W1949947453 @default.
• W2994833118 cites W1967811268 @default.
• W2994833118 cites W1975381773 @default.
• W2994833118 cites W1978484881 @default.
• W2994833118 cites W1978521888 @default.
• W2994833118 cites W1979313563 @default.
• W2994833118 cites W1980845575 @default.
• W2994833118 cites W1984692505 @default.
• W2994833118 cites W1987128031 @default.
• W2994833118 cites W1987728948 @default.
• W2994833118 cites W2025655040 @default.
• W2994833118 cites W2033658202 @default.
• W2994833118 cites W2043779385 @default.
• W2994833118 cites W2067449265 @default.
• W2994833118 cites W2075642592 @default.
• W2994833118 cites W2077348308 @default.
• W2994833118 cites W2082876871 @default.
• W2994833118 cites W2087374400 @default.
• W2994833118 cites W2089155165 @default.
• W2994833118 cites W2096967123 @default.
• W2994833118 cites W2098139332 @default.
• W2994833118 cites W2111464898 @default.
• W2994833118 cites W2111753882 @default.
• W2994833118 cites W2118634615 @default.
• W2994833118 cites W2128828064 @default.
• W2994833118 cites W2136376224 @default.
• W2994833118 cites W2140991283 @default.
• W2994833118 cites W2143490729 @default.
• W2994833118 cites W2165758561 @default.
• W2994833118 cites W2281194714 @default.
• W2994833118 cites W2289861197 @default.
• W2994833118 cites W2418272444 @default.
• W2994833118 cites W2483026649 @default.
• W2994833118 cites W2494229447 @default.
• W2994833118 cites W2601916337 @default.
• W2994833118 cites W2619579629 @default.
• W2994833118 cites W2680544593 @default.
• W2994833118 cites W2804769516 @default.
• W2994833118 cites W2888624163 @default.
• W2994833118 cites W2888865579 @default.
• W2994833118 cites W2903424067 @default.
• W2994833118 cites W2905379358 @default.
• W2994833118 cites W2913977146 @default.
• W2994833118 cites W4255396331 @default.
• W2994833118 doi "https://doi.org/10.1007/s11481-019-09883-w" @default.
• W2994833118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31820289" @default.
• W2994833118 hasPublicationYear "2019" @default.
• W2994833118 type Work @default.
• W2994833118 sameAs 2994833118 @default.
• W2994833118 citedByCount "11" @default.
• W2994833118 countsByYear W29948331182020 @default.
• W2994833118 countsByYear W29948331182021 @default.
• W2994833118 countsByYear W29948331182022 @default.
• W2994833118 countsByYear W29948331182023 @default.
• W2994833118 crossrefType "journal-article" @default.
• W2994833118 hasAuthorship W2994833118A5009963710 @default.
• W2994833118 hasAuthorship W2994833118A5042765290 @default.
• W2994833118 hasAuthorship W2994833118A5059477293 @default.
• W2994833118 hasAuthorship W2994833118A5059600880 @default.
• W2994833118 hasAuthorship W2994833118A5063288618 @default.
• W2994833118 hasAuthorship W2994833118A5068139431 @default.
• W2994833118 hasAuthorship W2994833118A5079506325 @default.
• W2994833118 hasBestOaLocation W29948331182 @default.
• W2994833118 hasConcept C118552586 @default.
• W2994833118 hasConcept C126322002 @default.
• W2994833118 hasConcept C142724271 @default.
• W2994833118 hasConcept C168563851 @default.
• W2994833118 hasConcept C204787440 @default.
• W2994833118 hasConcept C27081682 @default.
• W2994833118 hasConcept C2776914184 @default.
• W2994833118 hasConcept C2780376393 @default.
• W2994833118 hasConcept C2780687700 @default.
• W2994833118 hasConcept C71924100 @default.
• W2994833118 hasConcept C87753298 @default.
• W2994833118 hasConceptScore W2994833118C118552586 @default.
• W2994833118 hasConceptScore W2994833118C126322002 @default.
• W2994833118 hasConceptScore W2994833118C142724271 @default.
• W2994833118 hasConceptScore W2994833118C168563851 @default.
• W2994833118 hasConceptScore W2994833118C204787440 @default.
• W2994833118 hasConceptScore W2994833118C27081682 @default.
• W2994833118 hasConceptScore W2994833118C2776914184 @default.
• W2994833118 hasConceptScore W2994833118C2780376393 @default.
• W2994833118 hasConceptScore W2994833118C2780687700 @default.
• W2994833118 hasConceptScore W2994833118C71924100 @default.

• next