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- W2994835568 abstract "Three decades of studies have shown that inhibition of the substantia nigra pars reticulata (SNpr) attenuates seizures, yet the circuits mediating this effect remain obscure. SNpr projects to the deep and intermediate layers of the superior colliculus (DLSC) and the pedunculopontine nucleus (PPN), but the contributions of these projections are unknown. To address this gap, we optogenetically silenced cell bodies within SNpr, nigrotectal terminals within DLSC, and nigrotegmental terminals within PPN. Inhibition of cell bodies in SNpr suppressed generalized seizures evoked by pentylenetetrazole (PTZ), partial seizures evoked from the forebrain, absence seizures evoked by gamma-butyrolactone (GBL), and audiogenic seizures in genetically epilepsy-prone rats. Strikingly, these effects were fully recapitulated by silencing nigrotectal projections. By contrast, silencing nigrotegmental terminals reduced only absence seizures and exacerbated seizures evoked by PTZ. These data underscore the broad-spectrum anticonvulsant efficacy of this circuit, and demonstrate that specific efferent projection pathways differentially control different seizure types." @default.
- W2994835568 created "2019-12-26" @default.
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- W2994835568 date "2019-12-16" @default.
- W2994835568 modified "2023-09-27" @default.
- W2994835568 title "Descending projections from the <i>substantia nigra pars reticulata</i> differentially control seizures" @default.
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- W2994835568 doi "https://doi.org/10.1073/pnas.1908176117" @default.
- W2994835568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6936676" @default.
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- W2994835568 hasPublicationYear "2019" @default.
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