Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994844423> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W2994844423 abstract "Abstract Purpose Uveitis represents the fourth commonest cause of legal blindness in adult patients. Analysis of tear fluid proteins in acute anterior uveitis (AAU) patients could represent a novel diagnostic modality. This study aimed at detecting potential tear fluid biomarkers in patients with AAU and bacterial keratitis (BK). Methods Fourteen patients with unilateral AAU, seven patients with bacterial keratitis (BK) and 14 healthy age‐ and sex‐matched control subjects were included. Tear fluid samples were obtained by inserting two Schirmer’s test strips behind the lower eyelid of each eye for five minutes without anesthesia. Proteins were then identified by liquid chromatography tandem mass spectrometry. Pooled tear fluid samples from healthy controls were compared with samples from AAU and BK patients, respectively. Ingenuity Pathway Analysis (IPA) was used to explore biological function. Results A relative protein level was obtained for 235 proteins in AAU patients and 198 proteins in BK patients, while using healthy control subjects as reference. In AAU patients, nine proteins were at least two‐fold up‐regulated, whereas in BK patients, 12 proteins were up‐regulated more than two‐fold. None of the top ten upregulated proteins in AAU and BK overlapped. The top canonical pathway identified by IPA was ‘Acute Phase Response Signaling’ in AAU and ‘LXR/RXR activation’ in BK. Top upstream activated regulators included peroxisome proliferator activated receptor delta in AAU and interleukin 6 in BK. Conclusions Tear fluid protein analysis represents a promising diagnostic modality for ocular inflammatory diseases and demonstrate differentially expressed proteins in acute anterior uveitis and bacterial keratitis." @default.
- W2994844423 created "2019-12-26" @default.
- W2994844423 creator A5037641318 @default.
- W2994844423 date "2019-12-01" @default.
- W2994844423 modified "2023-10-17" @default.
- W2994844423 title "Tear proteome in uveitis" @default.
- W2994844423 doi "https://doi.org/10.1111/j.1755-3768.2019.8098" @default.
- W2994844423 hasPublicationYear "2019" @default.
- W2994844423 type Work @default.
- W2994844423 sameAs 2994844423 @default.
- W2994844423 citedByCount "0" @default.
- W2994844423 crossrefType "journal-article" @default.
- W2994844423 hasAuthorship W2994844423A5037641318 @default.
- W2994844423 hasBestOaLocation W29948444231 @default.
- W2994844423 hasConcept C104397665 @default.
- W2994844423 hasConcept C118487528 @default.
- W2994844423 hasConcept C203014093 @default.
- W2994844423 hasConcept C2776194053 @default.
- W2994844423 hasConcept C2778275304 @default.
- W2994844423 hasConcept C60644358 @default.
- W2994844423 hasConcept C71924100 @default.
- W2994844423 hasConcept C86803240 @default.
- W2994844423 hasConceptScore W2994844423C104397665 @default.
- W2994844423 hasConceptScore W2994844423C118487528 @default.
- W2994844423 hasConceptScore W2994844423C203014093 @default.
- W2994844423 hasConceptScore W2994844423C2776194053 @default.
- W2994844423 hasConceptScore W2994844423C2778275304 @default.
- W2994844423 hasConceptScore W2994844423C60644358 @default.
- W2994844423 hasConceptScore W2994844423C71924100 @default.
- W2994844423 hasConceptScore W2994844423C86803240 @default.
- W2994844423 hasIssue "S263" @default.
- W2994844423 hasLocation W29948444231 @default.
- W2994844423 hasOpenAccess W2994844423 @default.
- W2994844423 hasPrimaryLocation W29948444231 @default.
- W2994844423 hasRelatedWork W1973959357 @default.
- W2994844423 hasRelatedWork W1982829397 @default.
- W2994844423 hasRelatedWork W1994256748 @default.
- W2994844423 hasRelatedWork W2126785046 @default.
- W2994844423 hasRelatedWork W2159604840 @default.
- W2994844423 hasRelatedWork W2278759591 @default.
- W2994844423 hasRelatedWork W2360158017 @default.
- W2994844423 hasRelatedWork W2409161685 @default.
- W2994844423 hasRelatedWork W939517463 @default.
- W2994844423 hasRelatedWork W2120914721 @default.
- W2994844423 hasVolume "97" @default.
- W2994844423 isParatext "false" @default.
- W2994844423 isRetracted "false" @default.
- W2994844423 magId "2994844423" @default.
- W2994844423 workType "article" @default.