FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994862617> ?p ?o ?g. }

• W2994862617 endingPage "104746" @default.
• W2994862617 startingPage "104746" @default.
• W2994862617 abstract "Next Generation Risk Assessment (NGRA) is a procedure that integrates new approach methodologies (NAMs) to assure safety of a product without generating data from animal testing. One of the major challenges in the application of NGRA to consumer products is how to extrapolate from the in vitro points of departure (PoDs) to the human exposure level associated with product use. To bridge the gap, physiologically based kinetic (PBK) modelling is routinely used to predict systemic exposure (Cmax or AUC) from external exposures. A novel framework was developed for assessing the exposure of new ingredients in dermally applied products based on the construction of PBK models describing consumer habits and practices, formulation type, and ADME (absorption, distribution, metabolism and excretion) properties exclusively obtained from NAMs. This framework aims to quantify and reduce the uncertainty in predictions and is closely related to the risk assessment process (i.e., is the margin of safety sufficient to cover the uncertainties in the extrapolation between the in vitro and in vivo toxicodynamics and toxicokinetics?). Coumarin, caffeine, and sulforaphane in four product types (kitchen cleaner liquid, face cream, shampoo, and body lotion) were selected to exemplify how this framework could be used in practise. Our work shows initial levels of the framework provide a conservative estimate of Cmax in most cases which can be refined using sensitivity analysis to inform the choice of follow-up in vitro experiments. These case studies show the framework can increase confidence in use of PBK predictions for safety assessment." @default.
• W2994862617 created "2019-12-26" @default.
• W2994862617 creator A5022671567 @default.
• W2994862617 creator A5027470621 @default.
• W2994862617 creator A5039327442 @default.
• W2994862617 creator A5040371597 @default.
• W2994862617 creator A5041082540 @default.
• W2994862617 creator A5043181187 @default.
• W2994862617 creator A5065145337 @default.
• W2994862617 creator A5077095674 @default.
• W2994862617 creator A5088791532 @default.
• W2994862617 date "2020-03-01" @default.
• W2994862617 modified "2023-10-16" @default.
• W2994862617 title "Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products" @default.
• W2994862617 cites W1498305210 @default.
• W2994862617 cites W1501922076 @default.
• W2994862617 cites W1894357711 @default.
• W2994862617 cites W1968936982 @default.
• W2994862617 cites W1972200239 @default.
• W2994862617 cites W1982484840 @default.
• W2994862617 cites W1987776511 @default.
• W2994862617 cites W2018592667 @default.
• W2994862617 cites W2019167084 @default.
• W2994862617 cites W2025177410 @default.
• W2994862617 cites W2027143209 @default.
• W2994862617 cites W2028936105 @default.
• W2994862617 cites W2040233060 @default.
• W2994862617 cites W2076247932 @default.
• W2994862617 cites W2077656434 @default.
• W2994862617 cites W2127213687 @default.
• W2994862617 cites W2138874471 @default.
• W2994862617 cites W2164593300 @default.
• W2994862617 cites W2522795135 @default.
• W2994862617 cites W2547022267 @default.
• W2994862617 cites W2592769295 @default.
• W2994862617 cites W2751533746 @default.
• W2994862617 cites W2761819312 @default.
• W2994862617 cites W2783299760 @default.
• W2994862617 cites W2808720126 @default.
• W2994862617 cites W2884215650 @default.
• W2994862617 cites W2893678674 @default.
• W2994862617 cites W2899563949 @default.
• W2994862617 cites W2912877386 @default.
• W2994862617 cites W2916276802 @default.
• W2994862617 cites W2920163914 @default.
• W2994862617 doi "https://doi.org/10.1016/j.tiv.2019.104746" @default.
• W2994862617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31837441" @default.
• W2994862617 hasPublicationYear "2020" @default.
• W2994862617 type Work @default.
• W2994862617 sameAs 2994862617 @default.
• W2994862617 citedByCount "29" @default.
• W2994862617 countsByYear W29948626172020 @default.
• W2994862617 countsByYear W29948626172021 @default.
• W2994862617 countsByYear W29948626172022 @default.
• W2994862617 countsByYear W29948626172023 @default.
• W2994862617 crossrefType "journal-article" @default.
• W2994862617 hasAuthorship W2994862617A5022671567 @default.
• W2994862617 hasAuthorship W2994862617A5027470621 @default.
• W2994862617 hasAuthorship W2994862617A5039327442 @default.
• W2994862617 hasAuthorship W2994862617A5040371597 @default.
• W2994862617 hasAuthorship W2994862617A5041082540 @default.
• W2994862617 hasAuthorship W2994862617A5043181187 @default.
• W2994862617 hasAuthorship W2994862617A5065145337 @default.
• W2994862617 hasAuthorship W2994862617A5077095674 @default.
• W2994862617 hasAuthorship W2994862617A5088791532 @default.
• W2994862617 hasBestOaLocation W29948626171 @default.
• W2994862617 hasConcept C112705442 @default.
• W2994862617 hasConcept C112930515 @default.
• W2994862617 hasConcept C12174686 @default.
• W2994862617 hasConcept C127413603 @default.
• W2994862617 hasConcept C183696295 @default.
• W2994862617 hasConcept C195289149 @default.
• W2994862617 hasConcept C19749203 @default.
• W2994862617 hasConcept C22979827 @default.
• W2994862617 hasConcept C3020079912 @default.
• W2994862617 hasConcept C33070731 @default.
• W2994862617 hasConcept C38652104 @default.
• W2994862617 hasConcept C41008148 @default.
• W2994862617 hasConcept C71924100 @default.
• W2994862617 hasConcept C86803240 @default.
• W2994862617 hasConcept C98274493 @default.
• W2994862617 hasConceptScore W2994862617C112705442 @default.
• W2994862617 hasConceptScore W2994862617C112930515 @default.
• W2994862617 hasConceptScore W2994862617C12174686 @default.
• W2994862617 hasConceptScore W2994862617C127413603 @default.
• W2994862617 hasConceptScore W2994862617C183696295 @default.
• W2994862617 hasConceptScore W2994862617C195289149 @default.
• W2994862617 hasConceptScore W2994862617C19749203 @default.
• W2994862617 hasConceptScore W2994862617C22979827 @default.
• W2994862617 hasConceptScore W2994862617C3020079912 @default.
• W2994862617 hasConceptScore W2994862617C33070731 @default.
• W2994862617 hasConceptScore W2994862617C38652104 @default.
• W2994862617 hasConceptScore W2994862617C41008148 @default.
• W2994862617 hasConceptScore W2994862617C71924100 @default.
• W2994862617 hasConceptScore W2994862617C86803240 @default.
• W2994862617 hasConceptScore W2994862617C98274493 @default.
• W2994862617 hasLocation W29948626171 @default.
• W2994862617 hasOpenAccess W2994862617 @default.

• next