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- W2994865689 endingPage "087" @default.
- W2994865689 startingPage "070" @default.
- W2994865689 abstract "Variation in patterns of gene expression can result from modifications in the genome that occur without a change in the sequence of the DNA; such modifications include methylation of cytosine to generate 5-methylcytosine (5mC) resulting in the generation of heritable epimutation and novel epialleles. This type of non-sequence variation is called epigenetics. The enzymes responsible for generation of such DNA modifications in mammals are named DNA methyltransferases (DNMT) including DNMT1, DNMT2 and DNMT3. The later stages of oxidations to these modifications are catalyzed by Ten Eleven Translocation (TET) proteins, which contain catalytic domains belonging to the 2-oxoglutarate dependent dioxygenase family. In various mammalian cells/tissues including embryonic stem cells, cancer cells and brain tissues, it has been confirmed that these proteins are able to induce the stepwise oxidization of 5-methyl cytosine to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and finally 5-carboxylcytosine (5caC). Each stage from initial methylation until the end of the DNA demethylation process is considered as a specific epigenetic mark that may regulate gene expression. This review discusses controversial evidence for the presence of such oxidative products, particularly 5hmC, in various plant species. Whereas some reports suggest no evidence for enzymatic DNA demethylation, other reports suggest that the presence of oxidative products is followed by the active demethylation and indicate the contribution of possible TET-like proteins in the regulation of gene expression in plants. The review also summarizes the results obtained by expressing the human TET conserved catalytic domain in transgenic plants." @default.
- W2994865689 created "2019-12-26" @default.
- W2994865689 creator A5018120606 @default.
- W2994865689 creator A5089283074 @default.
- W2994865689 date "2019-12-01" @default.
- W2994865689 modified "2023-09-25" @default.
- W2994865689 title "Evidence for novel epigenetic marks within plants" @default.
- W2994865689 cites W1759180119 @default.
- W2994865689 cites W1788197058 @default.
- W2994865689 cites W1804063090 @default.
- W2994865689 cites W1965915737 @default.
- W2994865689 cites W1967184012 @default.
- W2994865689 cites W1970145665 @default.
- W2994865689 cites W1970148903 @default.
- W2994865689 cites W1971895280 @default.
- W2994865689 cites W1974215658 @default.
- W2994865689 cites W1981463058 @default.
- W2994865689 cites W1981543052 @default.
- W2994865689 cites W1988270702 @default.
- W2994865689 cites W1993480266 @default.
- W2994865689 cites W1995885578 @default.
- W2994865689 cites W1997796525 @default.
- W2994865689 cites W1997849784 @default.
- W2994865689 cites W2003217864 @default.
- W2994865689 cites W2004435886 @default.
- W2994865689 cites W2005935812 @default.
- W2994865689 cites W2005937797 @default.
- W2994865689 cites W2005971402 @default.
- W2994865689 cites W2010717707 @default.
- W2994865689 cites W2011874786 @default.
- W2994865689 cites W2020246476 @default.
- W2994865689 cites W2023361362 @default.
- W2994865689 cites W2024848067 @default.
- W2994865689 cites W2026343134 @default.
- W2994865689 cites W2026388592 @default.
- W2994865689 cites W2027593734 @default.
- W2994865689 cites W2031683963 @default.
- W2994865689 cites W2036082680 @default.
- W2994865689 cites W2036634503 @default.
- W2994865689 cites W2038449573 @default.
- W2994865689 cites W2038756976 @default.
- W2994865689 cites W2041837226 @default.
- W2994865689 cites W2044973377 @default.
- W2994865689 cites W2046878942 @default.
- W2994865689 cites W2047382548 @default.
- W2994865689 cites W2048780048 @default.
- W2994865689 cites W2049624700 @default.
- W2994865689 cites W2052023668 @default.
- W2994865689 cites W2059979506 @default.
- W2994865689 cites W2062907846 @default.
- W2994865689 cites W2065513741 @default.
- W2994865689 cites W2067151470 @default.
- W2994865689 cites W2067554307 @default.
- W2994865689 cites W2068050716 @default.
- W2994865689 cites W2069433314 @default.
- W2994865689 cites W2078336779 @default.
- W2994865689 cites W2085293170 @default.
- W2994865689 cites W2086278272 @default.
- W2994865689 cites W2096153482 @default.
- W2994865689 cites W2103109998 @default.
- W2994865689 cites W2103444581 @default.
- W2994865689 cites W2111538587 @default.
- W2994865689 cites W2118947151 @default.
- W2994865689 cites W2121304801 @default.
- W2994865689 cites W2125554759 @default.
- W2994865689 cites W2136810152 @default.
- W2994865689 cites W2137591958 @default.
- W2994865689 cites W2138088158 @default.
- W2994865689 cites W2138472595 @default.
- W2994865689 cites W2141231938 @default.
- W2994865689 cites W2143798330 @default.
- W2994865689 cites W2146301715 @default.
- W2994865689 cites W2148565377 @default.
- W2994865689 cites W2149254097 @default.
- W2994865689 cites W2150016122 @default.
- W2994865689 cites W2153122353 @default.
- W2994865689 cites W2154111088 @default.
- W2994865689 cites W2156386262 @default.
- W2994865689 cites W2156654220 @default.
- W2994865689 cites W2156825952 @default.
- W2994865689 cites W2161470337 @default.
- W2994865689 cites W2161980634 @default.
- W2994865689 cites W2165675499 @default.
- W2994865689 cites W2165719290 @default.
- W2994865689 cites W2170099595 @default.
- W2994865689 cites W2170964279 @default.
- W2994865689 cites W2225733508 @default.
- W2994865689 cites W2271549028 @default.
- W2994865689 cites W2273050936 @default.
- W2994865689 cites W2297701691 @default.
- W2994865689 cites W2300235862 @default.
- W2994865689 cites W2329238656 @default.
- W2994865689 cites W2336801953 @default.
- W2994865689 cites W2463493657 @default.
- W2994865689 cites W2523139278 @default.
- W2994865689 cites W2535006683 @default.
- W2994865689 cites W2609775308 @default.
- W2994865689 cites W2617540636 @default.