Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994865910> ?p ?o ?g. }
- W2994865910 abstract "Wound immersion in seawater with high salt, high sodium, and a high abundance of pathogenic bacteria, especially gram-negative bacteria, can cause serious infections and difficulties in wound repair. The present study aimed to prepare a composite hydrogel composed of hyaluronic acid (HA) and quaternized chitosan (QCS) that may promote wound healing of seawater-immersed wounds and prevent bacterial infection. Based on dynamic Schiff base linkage, hydrogel was prepared by mixing oxidized hyaluronic acid (OHA) and hyaluronic acid-hydrazide (HA-ADH) under physiological conditions. With the addition of quaternized chitosan, oxidized hyaluronic acid/hyaluronic acid-hydrazide/quaternized chitosan (OHA/HA-ADH/O-HACC and OHA/HA-ADH/N-HACC) composite hydrogels with good swelling properties and mechanical properties, appropriate water vapor transmission rates (WVTR), and excellent stability were prepared. The biocompatibility of the hydrogels was demonstrated by in vitro fibroblast L929 cell culture study. The results of in vitro and in vivo studies revealed that the prepared antibacterial hydrogels could largely inhibit bacterial growth. The in vivo study further demonstrated that the antibacterial hydrogels exhibited high repair efficiencies in a seawater-immersed wound defect model. In addition, the antibacterial hydrogels decreased pro-inflammatory factors (TNF-α, IL-1β, and IL-6) but enhanced anti-inflammatory factors (TGF-β1) in wound. This work indicates that the prepared antibacterial composite hydrogels have great potential in chronic wound healing applications, such as severe wound cure and treatment of open trauma infections." @default.
- W2994865910 created "2019-12-26" @default.
- W2994865910 creator A5029283324 @default.
- W2994865910 creator A5039932767 @default.
- W2994865910 creator A5040027239 @default.
- W2994865910 creator A5067289998 @default.
- W2994865910 creator A5082057680 @default.
- W2994865910 creator A5085532750 @default.
- W2994865910 creator A5089482554 @default.
- W2994865910 date "2019-12-10" @default.
- W2994865910 modified "2023-10-15" @default.
- W2994865910 title "Preparation of Antimicrobial Hyaluronic Acid/Quaternized Chitosan Hydrogels for the Promotion of Seawater-Immersion Wound Healing" @default.
- W2994865910 cites W1161655524 @default.
- W2994865910 cites W1983182466 @default.
- W2994865910 cites W1999710578 @default.
- W2994865910 cites W2000563588 @default.
- W2994865910 cites W2014181238 @default.
- W2994865910 cites W2043484320 @default.
- W2994865910 cites W2043774753 @default.
- W2994865910 cites W2047358291 @default.
- W2994865910 cites W2049399163 @default.
- W2994865910 cites W2053343035 @default.
- W2994865910 cites W2064395864 @default.
- W2994865910 cites W2081294651 @default.
- W2994865910 cites W2131551492 @default.
- W2994865910 cites W2141871529 @default.
- W2994865910 cites W2164159264 @default.
- W2994865910 cites W2269694779 @default.
- W2994865910 cites W2312366809 @default.
- W2994865910 cites W2340395657 @default.
- W2994865910 cites W2343606709 @default.
- W2994865910 cites W2415972197 @default.
- W2994865910 cites W2493113766 @default.
- W2994865910 cites W2559265493 @default.
- W2994865910 cites W2562696732 @default.
- W2994865910 cites W2579302807 @default.
- W2994865910 cites W2581123034 @default.
- W2994865910 cites W2590575726 @default.
- W2994865910 cites W2594338707 @default.
- W2994865910 cites W2603129706 @default.
- W2994865910 cites W2604297908 @default.
- W2994865910 cites W2605061698 @default.
- W2994865910 cites W2623332774 @default.
- W2994865910 cites W2736977131 @default.
- W2994865910 cites W2756315032 @default.
- W2994865910 cites W2787054622 @default.
- W2994865910 cites W2793939821 @default.
- W2994865910 cites W2797953917 @default.
- W2994865910 cites W2801556740 @default.
- W2994865910 cites W2804372249 @default.
- W2994865910 cites W2883448804 @default.
- W2994865910 cites W2888118846 @default.
- W2994865910 cites W2888344564 @default.
- W2994865910 cites W2888538445 @default.
- W2994865910 cites W2893805682 @default.
- W2994865910 cites W2897999456 @default.
- W2994865910 cites W2898717696 @default.
- W2994865910 cites W2909505539 @default.
- W2994865910 cites W2911086910 @default.
- W2994865910 cites W2916903224 @default.
- W2994865910 cites W2951494028 @default.
- W2994865910 cites W2963881852 @default.
- W2994865910 cites W2968898185 @default.
- W2994865910 cites W2972532984 @default.
- W2994865910 cites W2989144875 @default.
- W2994865910 cites W4211196871 @default.
- W2994865910 doi "https://doi.org/10.3389/fbioe.2019.00360" @default.
- W2994865910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6914676" @default.
- W2994865910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31921796" @default.
- W2994865910 hasPublicationYear "2019" @default.
- W2994865910 type Work @default.
- W2994865910 sameAs 2994865910 @default.
- W2994865910 citedByCount "43" @default.
- W2994865910 countsByYear W29948659102020 @default.
- W2994865910 countsByYear W29948659102021 @default.
- W2994865910 countsByYear W29948659102022 @default.
- W2994865910 countsByYear W29948659102023 @default.
- W2994865910 crossrefType "journal-article" @default.
- W2994865910 hasAuthorship W2994865910A5029283324 @default.
- W2994865910 hasAuthorship W2994865910A5039932767 @default.
- W2994865910 hasAuthorship W2994865910A5040027239 @default.
- W2994865910 hasAuthorship W2994865910A5067289998 @default.
- W2994865910 hasAuthorship W2994865910A5082057680 @default.
- W2994865910 hasAuthorship W2994865910A5085532750 @default.
- W2994865910 hasAuthorship W2994865910A5089482554 @default.
- W2994865910 hasBestOaLocation W29948659101 @default.
- W2994865910 hasConcept C105702510 @default.
- W2994865910 hasConcept C108586683 @default.
- W2994865910 hasConcept C13965031 @default.
- W2994865910 hasConcept C141071460 @default.
- W2994865910 hasConcept C150903083 @default.
- W2994865910 hasConcept C178790620 @default.
- W2994865910 hasConcept C185592680 @default.
- W2994865910 hasConcept C188027245 @default.
- W2994865910 hasConcept C207001950 @default.
- W2994865910 hasConcept C2777230088 @default.
- W2994865910 hasConcept C2777529286 @default.
- W2994865910 hasConcept C2779732960 @default.
- W2994865910 hasConcept C2780104969 @default.
- W2994865910 hasConcept C2780269544 @default.