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- W2994879321 abstract "Hippo signaling regulates the balance between cell proliferation and apoptosis to control the size of organs during development. Appropriate Hippo signaling is associated with stem cell differentiation, and inappropriate signaling can result in tumorigenesis and cancer. Hippo signaling activity is influenced not only by biochemical signals but also by mechanical force and the cytoskeleton transmitted through cell-cell junctions and cell-matrix adhesions. In this review, we describe the evidence for the regulation of Hippo signaling by the spatial reorganization of signaling components, mechanical force, and the cytoskeleton. Although our understanding of the relationship between Hippo signal transduction and mechanical force and the cytoskeleton is developing rapidly, many unresolved questions remain." @default.
- W2994879321 created "2019-12-26" @default.
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- W2994879321 date "2020-02-01" @default.
- W2994879321 modified "2023-09-28" @default.
- W2994879321 title "Regulation of Hippo Signaling by Mechanical Signals and the Cytoskeleton" @default.
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- W2994879321 doi "https://doi.org/10.1089/dna.2019.5087" @default.
- W2994879321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31821009" @default.
- W2994879321 hasPublicationYear "2020" @default.
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