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• W2994881339 abstract "Generating robust evidence within pediatric intensive care (PIC) can be challenging because of low patient numbers and patient heterogeneity. Systematic reviews may overcome small study biases but are limited by lack of standardization in outcome measures and their definition. Trials of nutrition interventions in PIC are increasing; thus, we wanted to examine the outcome measures being used in these trials.Our objective was to systematically describe outcome measures used when a nutrition intervention has been evaluated in a PIC randomized controlled trial.A systematic literature review of all studies involving a PIC trial of a nutrition intervention was undertaken from January 1, 1996, until February 20, 2018.Twenty-nine trials met the criteria and were reviewed. They included a total of 3226 patients across all trials. Thirty-seven primary outcomes and 83 secondary outcomes were found. These were categorized into PIC-related outcomes (infection, intensive care dependency, organ dysfunction, and mortality) and nutrition outcomes (energy targets, nutrition parameters, and feeding tolerance). We found large variation in the outcome measures used. Outcome domains of energy targets, feeding tolerance, and infection were not adequately defined.Considerable variation in the outcome measures chosen and their definitions exist within PIC nutrition trials. Optimal nutrition outcomes for PIC must be agreed upon and defined, specifically domains of nutrition efficiency, nutrition tolerance, and non-nutrition PIC outcomes. The next step is to conduct an international Delphi study to gain expert consensus and develop a core outcome set to be reported in future pediatric nutrition trials." @default.
• W2994881339 created "2019-12-26" @default.
• W2994881339 creator A5014161416 @default.
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• W2994881339 date "2020-02-03" @default.
• W2994881339 modified "2023-09-30" @default.
• W2994881339 title "Review of Outcomes Used in Nutrition Trials in Pediatric Critical Care" @default.
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• W2994881339 doi "https://doi.org/10.1002/jpen.1765" @default.
• W2994881339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32010996" @default.
• W2994881339 hasPublicationYear "2020" @default.
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