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• W2994920208 abstract "Abstract Background Prophylactic cotrimoxazole treatment is recommended in human immunodeficiency virus (HIV)–exposed, uninfected (HEU) infants, but the effects of this treatment on developing HEU infant gut microbiotas and resistomes are largely undefined. Methods We analyzed whole-metagenome sequencing data from 163 longitudinally collected stool samples from 63 HEU infants randomized to receive (n = 34; CTX-T) or to not receive (n = 29; CTX-N) prophylactic cotrimoxazole treatment. We generated taxonomic, functional pathway, and resistance gene profiles for each sample and compared microbiome signatures between the CTX-T and CTX-N infants. Results Metagenomic analysis did not reveal significant differences in taxonomic or functional pathway α-diversity between CTX-T and CTX-N infants. In contrast, resistance gene prevalence (P = .00719) and α-diversity (P = .0045) increased in CTX-T infants. These differences increased over time for both resistance gene prevalence measured by log-normalized abundance (4-month mean, 0.71 [95% confidence interval {CI}, .2–1.2] and 6-month mean, 0.85 [95% CI, .1–1.7]) and α-diversity (P = .0045). Unlike α-diversity, interindividual gut microbiome taxonomic (mean, −0.11 [95% CI, −.15 to −.077]), functional taxonomic (mean, −0.050 [95% CI, −.084 to −.017]), and resistance gene (mean, −0.13 [95% CI, −.17 to −.099]) β-diversity decreased in CTX-T infants compared with CTX-N infants. These results are consistent with persistent antibiotic selection pressure. Conclusions Cotrimoxazole prophylaxis in HEU infants decreased gut microbiome β-diversity and increased antibiotic resistance gene α-diversity and prevalence. Antibiotic resistance is a growing threat, especially in low- and middle-income countries where the higher perinatal HIV exposure rates result in cotrimoxazole prophylaxis. Understanding effects from current HEU infant antibiotic prophylaxis guidelines will inform guideline revisions and efforts to reduce increasing antibiotic resistance." @default.
• W2994920208 created "2019-12-26" @default.
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• W2994920208 date "2019-12-13" @default.
• W2994920208 modified "2023-10-16" @default.
• W2994920208 title "Cotrimoxazole Prophylaxis Increases Resistance Gene Prevalence and α-Diversity but Decreases β-Diversity in the Gut Microbiome of Human Immunodeficiency Virus–Exposed, Uninfected Infants" @default.
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• W2994920208 cites W1985627556 @default.
• W2994920208 cites W1991071311 @default.
• W2994920208 cites W2003202328 @default.
• W2994920208 cites W2006969147 @default.
• W2994920208 cites W2032605132 @default.
• W2994920208 cites W2032705009 @default.
• W2994920208 cites W2043442946 @default.
• W2994920208 cites W2063158722 @default.
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• W2994920208 cites W2096526472 @default.
• W2994920208 cites W2097557545 @default.
• W2994920208 cites W2102461176 @default.
• W2994920208 cites W2110189329 @default.
• W2994920208 cites W2112677717 @default.
• W2994920208 cites W2124171473 @default.
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• W2994920208 cites W2148521133 @default.
• W2994920208 cites W2155004764 @default.
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• W2994920208 cites W2343758687 @default.
• W2994920208 cites W2346250763 @default.
• W2994920208 cites W2422385316 @default.
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• W2994920208 cites W2470154003 @default.
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• W2994920208 doi "https://doi.org/10.1093/cid/ciz1186" @default.
• W2994920208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7778358" @default.
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