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• W2995022850 abstract "The intracellularly active bacterial toxin TcdB is a major Clostridioides difficile virulence factor that contributes to inflammation and tissue damage during disease. Immunization with an inactive TcdB fragment prevents C. difficile infection (CDI)-associated pathology. The protective immune response against inactive TcdB involves development of antigen-specific memory B cells and long-lived plasma cells that encode TcdB-neutralizing antibodies. Unlike the response to inactive TcdB, very little is known about the host humoral immune response to C. difficile and TcdB during primary and recurrent infection." @default.
• W2995022850 created "2019-12-26" @default.
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• W2995022850 date "2020-02-20" @default.
• W2995022850 modified "2023-09-24" @default.
• W2995022850 title "Clostridioides difficile Infection Induces an Inferior IgG Response to That Induced by Immunization and Is Associated with a Lack of T Follicular Helper Cell and Memory B Cell Expansion" @default.
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• W2995022850 doi "https://doi.org/10.1128/iai.00829-19" @default.
• W2995022850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7035940" @default.
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