Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995103669> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W2995103669 endingPage "103" @default.
- W2995103669 startingPage "96" @default.
- W2995103669 abstract "ABSTRACT Currently, the in silico calculation of intracellular fluxes in biological systems is a widely used tool in Systems Biology. This method is based on the hypothesis that these systems work optimally with respect to certain biological criteria. Jointly, they are considered a set of constraints that pass since the imposition of a steady-state to the system, until physicochemical and experimental constraints. These elements allow, through linear programming models, to obtain a vector space that containing metabolic fluxes in a biochemical reactions networks. The solutions of these generated models permit the simulation of the metabolic flux distributions to maximize or minimize an objective function in a biological system. In this sense we developed HYDRA: Flux Balance Analysis, that it is a computer tool, than using the algorithm Simplex Reviewed, solves the constructed models and generate output reports that constitute an important tool for making decisions in System Biology. KEYWORDS: Flux Balance Analysis, Genome-scale metabolic models, Metabolic Fluxes, Linear Programming. MSC: 90C05 RESUMEN Actualmente el calculo in silico de los flujos intracelulares en los sistemas biologicos constituye una herramienta muy usada en Biologia de Sistemas. Este metodo se basa en la hipotesis de que estos sistemas funcionan de forma optima respecto a cierto criterio biologico. Conjuntamente son consideradas restricciones que pasan, desde la imposicion de un estado estacionario al sistema, hasta restricciones fisico-quimicas y experimentales. Estos elementos permiten obtener, a traves de modelos de programacion lineal, un espacio vectorial que contienen los flujos metabolicos en una red de reacciones bioquimicas. La solucion de estos modelos generados, permite simular las distribuciones de flujo metabolicos al maximizar o minimizar una funcion objetivo en un sistema biologico. En este sentido se desarrollo HYDRA: Flux Balance Analysis, que es una herramienta informatica que, utilizando el algoritmo Simplex Revisado, soluciona los modelos construidos y genera informes de salida que constituyen importante herramienta para la toma de decisiones en la Biologia de Sistema." @default.
- W2995103669 created "2019-12-26" @default.
- W2995103669 creator A5001671539 @default.
- W2995103669 creator A5008701709 @default.
- W2995103669 creator A5039281171 @default.
- W2995103669 creator A5059806043 @default.
- W2995103669 creator A5068782304 @default.
- W2995103669 creator A5068989327 @default.
- W2995103669 creator A5072278746 @default.
- W2995103669 creator A5087999882 @default.
- W2995103669 date "2014-01-01" @default.
- W2995103669 modified "2023-09-27" @default.
- W2995103669 title "HERRAMIENTA PARA LA OPTIMIZACIÓN DE FLUJOS METABÓLICOS EN UN SISTEMA BIOLÓGICO." @default.
- W2995103669 hasPublicationYear "2014" @default.
- W2995103669 type Work @default.
- W2995103669 sameAs 2995103669 @default.
- W2995103669 citedByCount "1" @default.
- W2995103669 countsByYear W29951036692019 @default.
- W2995103669 crossrefType "journal-article" @default.
- W2995103669 hasAuthorship W2995103669A5001671539 @default.
- W2995103669 hasAuthorship W2995103669A5008701709 @default.
- W2995103669 hasAuthorship W2995103669A5039281171 @default.
- W2995103669 hasAuthorship W2995103669A5059806043 @default.
- W2995103669 hasAuthorship W2995103669A5068782304 @default.
- W2995103669 hasAuthorship W2995103669A5068989327 @default.
- W2995103669 hasAuthorship W2995103669A5072278746 @default.
- W2995103669 hasAuthorship W2995103669A5087999882 @default.
- W2995103669 hasConcept C138885662 @default.
- W2995103669 hasConcept C15708023 @default.
- W2995103669 hasConcept C167091322 @default.
- W2995103669 hasConcept C41008148 @default.
- W2995103669 hasConcept C70721500 @default.
- W2995103669 hasConcept C86803240 @default.
- W2995103669 hasConceptScore W2995103669C138885662 @default.
- W2995103669 hasConceptScore W2995103669C15708023 @default.
- W2995103669 hasConceptScore W2995103669C167091322 @default.
- W2995103669 hasConceptScore W2995103669C41008148 @default.
- W2995103669 hasConceptScore W2995103669C70721500 @default.
- W2995103669 hasConceptScore W2995103669C86803240 @default.
- W2995103669 hasIssue "2" @default.
- W2995103669 hasLocation W29951036691 @default.
- W2995103669 hasOpenAccess W2995103669 @default.
- W2995103669 hasPrimaryLocation W29951036691 @default.
- W2995103669 hasVolume "35" @default.
- W2995103669 isParatext "false" @default.
- W2995103669 isRetracted "false" @default.
- W2995103669 magId "2995103669" @default.
- W2995103669 workType "article" @default.