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- W2995111339 startingPage "2073" @default.
- W2995111339 abstract "Abstract General molecular principles of ribosome biogenesis have been well explored in bacteria and eukaryotes. Collectively, these studies have revealed important functional differences and few similarities between these processes. Phylogenetic studies suggest that the information processing machineries from archaea and eukaryotes are evolutionary more closely related than their bacterial counterparts. These observations raise the question of how ribosome synthesis in archaea may proceed in vivo. In this study, we describe a versatile plasmid-based cis-acting reporter system allowing to analyze in vivo the consequences of ribosomal RNA mutations in the model archaeon Haloferax volcanii. Applying this system, we provide evidence that the bulge-helix-bulge motif enclosed within the ribosomal RNA processing stems is required for the formation of archaeal-specific circular-pre-rRNA intermediates and mature rRNAs. In addition, we have collected evidences suggesting functional coordination of the early steps of ribosome synthesis in H. volcanii. Together our investigation describes a versatile platform allowing to generate and functionally analyze the fate of diverse rRNA variants, thereby paving the way to better understand the cis-acting molecular determinants necessary for archaeal ribosome synthesis, maturation, stability and function." @default.
- W2995111339 created "2019-12-26" @default.
- W2995111339 creator A5002817811 @default.
- W2995111339 creator A5012890390 @default.
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- W2995111339 creator A5030950685 @default.
- W2995111339 creator A5054742160 @default.
- W2995111339 creator A5069049188 @default.
- W2995111339 date "2019-12-12" @default.
- W2995111339 modified "2023-10-12" @default.
- W2995111339 title "A versatile cis-acting element reporter system to study the function, maturation and stability of ribosomal RNA mutants in archaea" @default.
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