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- W2995162523 endingPage "13" @default.
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- W2995162523 abstract "Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players in molecular signaling and cell fate determination through reactive oxygen species (ROS). While ROS production has historically been portrayed as an unregulated process driving oxidative stress and disease pathology, contemporary studies reveal that ROS also facilitate normal physiology. Mitochondria are especially abundant in cardiac tissue; hence, mitochondrial dysregulation and ROS production are thought to contribute significantly to cardiac pathology. Moreover, there is growing appreciation that medical therapies designed to mediate mitochondrial ROS production can be important strategies to ameliorate cardiac disease. In this review, we highlight evidence from animal models that illustrates the strong connections between mitochondrial ROS and cardiac disease, discuss advancements in the development of mitochondria-targeted antioxidant therapies, and identify challenges faced in bringing such therapies into the clinic." @default.
- W2995162523 created "2019-12-26" @default.
- W2995162523 creator A5003210836 @default.
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- W2995162523 creator A5022292284 @default.
- W2995162523 creator A5040025655 @default.
- W2995162523 creator A5067041776 @default.
- W2995162523 date "2019-12-01" @default.
- W2995162523 modified "2023-10-10" @default.
- W2995162523 title "Mitochondrial dysfunction and oxidative stress in heart disease" @default.
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