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- W2995223053 abstract "Intracortical microstimulation can be used successfully to modulate neuronal activity. Activity-dependent stimulation (ADS), in which action potentials recorded extracellularly from a single neuron are used to trigger stimulation at another cortical location (closed-loop), is an effective treatment for behavioral recovery after brain lesion, but the related neurophysiological changes are still not clear. Here, we investigated the ability of ADS and random stimulation (RS) to alter firing patterns of distant cortical locations. We recorded 591 neuronal units from 23 Long-Evan healthy anesthetized rats. Stimulation was delivered to either forelimb or barrel field somatosensory cortex, using either RS or ADS triggered from spikes recorded in the rostral forelimb area (RFA). Both RS and ADS stimulation protocols rapidly altered spike firing within RFA compared with no stimulation. We observed increase in firing rates and change of spike patterns. ADS was more effective than RS in increasing evoked spikes during the stimulation periods, by producing a reliable, progressive increase in stimulus-related activity over time and an increased coupling of the trigger channel with the network. These results are critical for understanding the efficacy of closed-loop electrical microstimulation protocols in altering activity patterns in interconnected brain networks, thus modulating cortical state and functional connectivity." @default.
- W2995223053 created "2019-12-26" @default.
- W2995223053 creator A5015854658 @default.
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- W2995223053 date "2019-12-11" @default.
- W2995223053 modified "2023-10-16" @default.
- W2995223053 title "Differential Effects of Open- and Closed-Loop Intracortical Microstimulation on Firing Patterns of Neurons in Distant Cortical Areas" @default.
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- W2995223053 doi "https://doi.org/10.1093/cercor/bhz281" @default.
- W2995223053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7197073" @default.
- W2995223053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31832642" @default.
- W2995223053 hasPublicationYear "2019" @default.
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