FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995245895> ?p ?o ?g. }

• W2995245895 endingPage "112484" @default.
• W2995245895 startingPage "112484" @default.
• W2995245895 abstract "A promising approach to treat a variety of diseases are considered as complementary and alternative herbal medicines. Prunus serrulata var. spontanea L. (Rosaceae) is used as herbal medicine to treat allergic diseases according to the Donguibogam, a tradition medical book of the Joseon Dynasty in Korea. We prepared the aqueous extract of the bark of P. serrulata (AEBPS) and aimed to investigate the effects in mouse anaphylaxis models and various types of mast cells, including RBL-2H3, primary cultured peritoneal and bone marrow-derived mast cells. We used ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) and immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis (PCA) models, in vivo. The control drug dexamethasone (10 mg/kg) was used to compare the effectiveness of AEBPS (1–100 mg/kg). In vitro, IgE-stimulated mast cells were used to confirm the role of AEBPS (1–100 μg/mL). For statistical analyses, p values less than 0.05 were considered to be significant. In ASA model, oral administration of AEBPS suppressed the hypothermia and increased level of serum histamine in a dose-dependent manner. AEBPS attenuated the serum IgE, OVA-specific IgE, and interleukin (IL)-4. Oral administration of AEBPS also blocked mast cell-dependent PCA. AEBPS suppressed degranulation of mast cells by reducing intracellular calcium level in mast cells. AEBPS inhibited tumor necrosis factor-α and IL-4 expression and secretion in a concentration-dependent manner through the reduction of nuclear factor-κB. On the basis of these findings, AEBPS could serve as a potential therapeutic target for the management of mast cell-mediated allergic inflammation and as a regulator of mast cell activation." @default.
• W2995245895 created "2019-12-26" @default.
• W2995245895 creator A5005487766 @default.
• W2995245895 creator A5008841175 @default.
• W2995245895 creator A5024605311 @default.
• W2995245895 creator A5027945729 @default.
• W2995245895 creator A5034003059 @default.
• W2995245895 creator A5034268961 @default.
• W2995245895 creator A5037496831 @default.
• W2995245895 creator A5044398420 @default.
• W2995245895 creator A5061206062 @default.
• W2995245895 creator A5066164491 @default.
• W2995245895 date "2020-03-01" @default.
• W2995245895 modified "2023-10-13" @default.
• W2995245895 title "Prunus serrulata var. spontanea inhibits mast cell activation and mast cell-mediated anaphylaxis" @default.
• W2995245895 cites W1550729667 @default.
• W2995245895 cites W1581086735 @default.
• W2995245895 cites W1590937134 @default.
• W2995245895 cites W1942487602 @default.
• W2995245895 cites W1956369936 @default.
• W2995245895 cites W1970877848 @default.
• W2995245895 cites W1972447401 @default.
• W2995245895 cites W1972518218 @default.
• W2995245895 cites W1979278210 @default.
• W2995245895 cites W1979398938 @default.
• W2995245895 cites W1982386486 @default.
• W2995245895 cites W1986019597 @default.
• W2995245895 cites W1988841862 @default.
• W2995245895 cites W1991790975 @default.
• W2995245895 cites W1993419504 @default.
• W2995245895 cites W1994354305 @default.
• W2995245895 cites W1995292978 @default.
• W2995245895 cites W2000974543 @default.
• W2995245895 cites W2004633568 @default.
• W2995245895 cites W2005744646 @default.
• W2995245895 cites W2007589345 @default.
• W2995245895 cites W2010980103 @default.
• W2995245895 cites W2046380655 @default.
• W2995245895 cites W2050915488 @default.
• W2995245895 cites W2051624640 @default.
• W2995245895 cites W2052301327 @default.
• W2995245895 cites W2057345517 @default.
• W2995245895 cites W2063967757 @default.
• W2995245895 cites W2066964307 @default.
• W2995245895 cites W2070384611 @default.
• W2995245895 cites W2079196655 @default.
• W2995245895 cites W2084586473 @default.
• W2995245895 cites W2086830787 @default.
• W2995245895 cites W2106480520 @default.
• W2995245895 cites W2111123666 @default.
• W2995245895 cites W2121461472 @default.
• W2995245895 cites W2130339011 @default.
• W2995245895 cites W2132961930 @default.
• W2995245895 cites W2142384246 @default.
• W2995245895 cites W2147837456 @default.
• W2995245895 cites W2148119611 @default.
• W2995245895 cites W2153089565 @default.
• W2995245895 cites W2164989387 @default.
• W2995245895 cites W2330381740 @default.
• W2995245895 cites W2331546093 @default.
• W2995245895 cites W2468706945 @default.
• W2995245895 cites W2558597122 @default.
• W2995245895 cites W2559516988 @default.
• W2995245895 cites W2593907008 @default.
• W2995245895 cites W2602877786 @default.
• W2995245895 cites W2735527928 @default.
• W2995245895 cites W2744715029 @default.
• W2995245895 cites W2768933139 @default.
• W2995245895 cites W2805020018 @default.
• W2995245895 cites W2943272945 @default.
• W2995245895 cites W378750494 @default.
• W2995245895 doi "https://doi.org/10.1016/j.jep.2019.112484" @default.
• W2995245895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31843576" @default.
• W2995245895 hasPublicationYear "2020" @default.
• W2995245895 type Work @default.
• W2995245895 sameAs 2995245895 @default.
• W2995245895 citedByCount "3" @default.
• W2995245895 countsByYear W29952458952020 @default.
• W2995245895 countsByYear W29952458952021 @default.
• W2995245895 countsByYear W29952458952022 @default.
• W2995245895 crossrefType "journal-article" @default.
• W2995245895 hasAuthorship W2995245895A5005487766 @default.
• W2995245895 hasAuthorship W2995245895A5008841175 @default.
• W2995245895 hasAuthorship W2995245895A5024605311 @default.
• W2995245895 hasAuthorship W2995245895A5027945729 @default.
• W2995245895 hasAuthorship W2995245895A5034003059 @default.
• W2995245895 hasAuthorship W2995245895A5034268961 @default.
• W2995245895 hasAuthorship W2995245895A5037496831 @default.
• W2995245895 hasAuthorship W2995245895A5044398420 @default.
• W2995245895 hasAuthorship W2995245895A5061206062 @default.
• W2995245895 hasAuthorship W2995245895A5066164491 @default.
• W2995245895 hasConcept C1122143 @default.
• W2995245895 hasConcept C126322002 @default.
• W2995245895 hasConcept C141105273 @default.
• W2995245895 hasConcept C150903083 @default.
• W2995245895 hasConcept C159654299 @default.
• W2995245895 hasConcept C170493617 @default.
• W2995245895 hasConcept C203014093 @default.

• next