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• W2995368126 abstract "Previously we reported that a process called inter-fork strand annealing (IFSA) causes genomic deletions during the termination of DNA replication when an active replication fork converges on a collapsed fork (Morrow et al., 2017). We also identified the FANCM-related DNA helicase Fml1 as a potential suppressor of IFSA. Here, we confirm that Fml1 does indeed suppress IFSA, and show that this function depends on its catalytic activity and ability to interact with Mhf1-Mhf2 via its C-terminal domain. Finally, a plausible mechanism of IFSA suppression is demonstrated by the finding that Fml1 can catalyse regressed fork restoration in vitro." @default.
• W2995368126 created "2019-12-26" @default.
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• W2995368126 date "2019-12-19" @default.
• W2995368126 modified "2023-10-18" @default.
• W2995368126 title "The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast" @default.
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• W2995368126 doi "https://doi.org/10.7554/elife.49784" @default.
• W2995368126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6952179" @default.
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• W2995368126 hasPublicationYear "2019" @default.
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