Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995377552> ?p ?o ?g. }
- W2995377552 endingPage "60" @default.
- W2995377552 startingPage "54" @default.
- W2995377552 abstract "Ricin toxin (RT) is a natural plant-derived protein toxin from the seed of castor beans that belongs to a family of type II ribosome-inactivating proteins (RIPs). In addition to its main toxic mechanism of inhibiting the synthesis of cellular proteins, RT can induce the production of inflammatory cytokines and cause inflammatory injury. Macrophages play a crucial role in innate immunity and the adaptive immune response as the first line of host defense against bacterial infections and various types of invading pathogens. Upon activation, macrophages release types of cytokines to remove pathogens. However, the effect of RT on the immune response and its mechanism are not well characterized. In the current study, we investigated the activation of the TLR4-mediated signaling pathway by low-dose RT treatment and its interaction with signaling molecules in the transduction pathway. We found that low-dose RT can activate MyD88- and TRIF-dependent signaling pathways, revealing a possible mechanism by which low-dose RT-activates TLR4-mediated signaling pathways. We also confirmed that the TLR4-induced activation of the inflammatory signaling pathways was produced via its binding to RT. This study may help to identify the most important target molecules and clarify the mechanism of inflammatory injury of ricin." @default.
- W2995377552 created "2019-12-26" @default.
- W2995377552 creator A5003642180 @default.
- W2995377552 creator A5005618556 @default.
- W2995377552 creator A5010163028 @default.
- W2995377552 creator A5014888350 @default.
- W2995377552 creator A5016664573 @default.
- W2995377552 creator A5055565678 @default.
- W2995377552 creator A5058915563 @default.
- W2995377552 creator A5069862111 @default.
- W2995377552 creator A5074688928 @default.
- W2995377552 date "2020-03-01" @default.
- W2995377552 modified "2023-10-17" @default.
- W2995377552 title "Critical role of toll-like receptor 4 (TLR4) in ricin toxin-induced inflammatory responses in macrophages" @default.
- W2995377552 cites W1967269498 @default.
- W2995377552 cites W1971407740 @default.
- W2995377552 cites W1978094899 @default.
- W2995377552 cites W1981656518 @default.
- W2995377552 cites W1992245975 @default.
- W2995377552 cites W1993211211 @default.
- W2995377552 cites W1995744610 @default.
- W2995377552 cites W1996626616 @default.
- W2995377552 cites W2004465286 @default.
- W2995377552 cites W2009983256 @default.
- W2995377552 cites W2013601771 @default.
- W2995377552 cites W2015263036 @default.
- W2995377552 cites W2015730823 @default.
- W2995377552 cites W2016755802 @default.
- W2995377552 cites W2017267009 @default.
- W2995377552 cites W2017540881 @default.
- W2995377552 cites W2026134797 @default.
- W2995377552 cites W2031747611 @default.
- W2995377552 cites W2035152881 @default.
- W2995377552 cites W2038554653 @default.
- W2995377552 cites W2053429123 @default.
- W2995377552 cites W2061071136 @default.
- W2995377552 cites W2061123122 @default.
- W2995377552 cites W2063148079 @default.
- W2995377552 cites W2065479363 @default.
- W2995377552 cites W2067384813 @default.
- W2995377552 cites W2074994532 @default.
- W2995377552 cites W2075113278 @default.
- W2995377552 cites W2075931876 @default.
- W2995377552 cites W2077995361 @default.
- W2995377552 cites W2082594846 @default.
- W2995377552 cites W2106248075 @default.
- W2995377552 cites W2120919686 @default.
- W2995377552 cites W2130421043 @default.
- W2995377552 cites W2133449490 @default.
- W2995377552 cites W2167299815 @default.
- W2995377552 cites W2169244146 @default.
- W2995377552 cites W2171160165 @default.
- W2995377552 cites W2409155655 @default.
- W2995377552 cites W4230785217 @default.
- W2995377552 cites W609353368 @default.
- W2995377552 doi "https://doi.org/10.1016/j.toxlet.2019.12.021" @default.
- W2995377552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31862508" @default.
- W2995377552 hasPublicationYear "2020" @default.
- W2995377552 type Work @default.
- W2995377552 sameAs 2995377552 @default.
- W2995377552 citedByCount "14" @default.
- W2995377552 countsByYear W29953775522020 @default.
- W2995377552 countsByYear W29953775522021 @default.
- W2995377552 countsByYear W29953775522022 @default.
- W2995377552 countsByYear W29953775522023 @default.
- W2995377552 crossrefType "journal-article" @default.
- W2995377552 hasAuthorship W2995377552A5003642180 @default.
- W2995377552 hasAuthorship W2995377552A5005618556 @default.
- W2995377552 hasAuthorship W2995377552A5010163028 @default.
- W2995377552 hasAuthorship W2995377552A5014888350 @default.
- W2995377552 hasAuthorship W2995377552A5016664573 @default.
- W2995377552 hasAuthorship W2995377552A5055565678 @default.
- W2995377552 hasAuthorship W2995377552A5058915563 @default.
- W2995377552 hasAuthorship W2995377552A5069862111 @default.
- W2995377552 hasAuthorship W2995377552A5074688928 @default.
- W2995377552 hasConcept C136449434 @default.
- W2995377552 hasConcept C170493617 @default.
- W2995377552 hasConcept C185592680 @default.
- W2995377552 hasConcept C203014093 @default.
- W2995377552 hasConcept C2776070231 @default.
- W2995377552 hasConcept C2776709828 @default.
- W2995377552 hasConcept C2777200438 @default.
- W2995377552 hasConcept C2777367657 @default.
- W2995377552 hasConcept C43929388 @default.
- W2995377552 hasConcept C55493867 @default.
- W2995377552 hasConcept C62478195 @default.
- W2995377552 hasConcept C86803240 @default.
- W2995377552 hasConcept C8891405 @default.
- W2995377552 hasConcept C89423630 @default.
- W2995377552 hasConcept C95444343 @default.
- W2995377552 hasConceptScore W2995377552C136449434 @default.
- W2995377552 hasConceptScore W2995377552C170493617 @default.
- W2995377552 hasConceptScore W2995377552C185592680 @default.
- W2995377552 hasConceptScore W2995377552C203014093 @default.
- W2995377552 hasConceptScore W2995377552C2776070231 @default.
- W2995377552 hasConceptScore W2995377552C2776709828 @default.
- W2995377552 hasConceptScore W2995377552C2777200438 @default.
- W2995377552 hasConceptScore W2995377552C2777367657 @default.