FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995476775> ?p ?o ?g. }

• W2995476775 endingPage "198" @default.
• W2995476775 startingPage "190" @default.
• W2995476775 abstract "SGLT2 inhibitors are a new class of antihyperglycemic drugs that protect kidneys and hearts of type 2 diabetic (T2DM) patients with preserved kidney function from failing. Here we discuss new insights on renal protection.Also in T2DM patients with CKD, SGLT2 inhibition causes an immediate functional reduction in glomerular filtration rate (GFR) and reduces blood pressure and preserves kidney and heart function in the long-term, despite a lesser antihyperglycemic effect. According to modeling studies, the GFR reduction reduces the tubular transport work and metabolic demand, thereby improving renal cortical oxygenation. In humans, the latter is linked to protection from CKD. Urine metabolomics in T2DM patients suggested improved renal mitochondrial function in response to SGLT2 inhibition, and experimental studies indicated improved tubular autophagy. Modeling studies predicted that also in diabetic CKD, SGLT2 inhibition is natriuretic and potentially stimulates erythropoiesis by mimicking systemic hypoxia in the kidney. Meta-analyses indicated that SGLT2 inhibition also reduces risk and severity of acute kidney injury in T2DM patients. Studies in nondiabetic mice implied inhibition of the renal urate transporter URAT1 in the uricosuric effect of SGLT2 inhibition.Renoprotection of SGLT2 inhibition involves blood glucose-dependent and independent effects and extends to CKD." @default.
• W2995476775 created "2019-12-26" @default.
• W2995476775 creator A5063256319 @default.
• W2995476775 creator A5085734264 @default.
• W2995476775 date "2020-03-01" @default.
• W2995476775 modified "2023-10-10" @default.
• W2995476775 title "Renal effects of SGLT2 inhibitors" @default.
• W2995476775 cites W1888211049 @default.
• W2995476775 cites W1966187721 @default.
• W2995476775 cites W2027545319 @default.
• W2995476775 cites W2097224352 @default.
• W2995476775 cites W2128814368 @default.
• W2995476775 cites W2168817129 @default.
• W2995476775 cites W2168910111 @default.
• W2995476775 cites W2238341693 @default.
• W2995476775 cites W2421137370 @default.
• W2995476775 cites W2424539745 @default.
• W2995476775 cites W2553261268 @default.
• W2995476775 cites W2588592529 @default.
• W2995476775 cites W2595201361 @default.
• W2995476775 cites W2604816492 @default.
• W2995476775 cites W2727622516 @default.
• W2995476775 cites W2754469738 @default.
• W2995476775 cites W2782820380 @default.
• W2995476775 cites W2783453311 @default.
• W2995476775 cites W2786750563 @default.
• W2995476775 cites W2791162071 @default.
• W2995476775 cites W2793450493 @default.
• W2995476775 cites W2800392787 @default.
• W2995476775 cites W2805527427 @default.
• W2995476775 cites W2809595382 @default.
• W2995476775 cites W2810892857 @default.
• W2995476775 cites W2884817413 @default.
• W2995476775 cites W2885657542 @default.
• W2995476775 cites W2887628755 @default.
• W2995476775 cites W2898388822 @default.
• W2995476775 cites W2900227157 @default.
• W2995476775 cites W2900413769 @default.
• W2995476775 cites W2900620576 @default.
• W2995476775 cites W2906964607 @default.
• W2995476775 cites W2914038117 @default.
• W2995476775 cites W2916296804 @default.
• W2995476775 cites W2917112529 @default.
• W2995476775 cites W2922268276 @default.
• W2995476775 cites W2936122593 @default.
• W2995476775 cites W2936559636 @default.
• W2995476775 cites W2939222610 @default.
• W2995476775 cites W2942519534 @default.
• W2995476775 cites W2945808868 @default.
• W2995476775 cites W2946478556 @default.
• W2995476775 cites W2948205308 @default.
• W2995476775 cites W2949665037 @default.
• W2995476775 cites W2954378976 @default.
• W2995476775 cites W2965465952 @default.
• W2995476775 cites W2969703976 @default.
• W2995476775 cites W2969725967 @default.
• W2995476775 cites W2971414122 @default.
• W2995476775 cites W2973242786 @default.
• W2995476775 doi "https://doi.org/10.1097/mnh.0000000000000584" @default.
• W2995476775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7224333" @default.
• W2995476775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31815757" @default.
• W2995476775 hasPublicationYear "2020" @default.
• W2995476775 type Work @default.
• W2995476775 sameAs 2995476775 @default.
• W2995476775 citedByCount "59" @default.
• W2995476775 countsByYear W29954767752020 @default.
• W2995476775 countsByYear W29954767752021 @default.
• W2995476775 countsByYear W29954767752022 @default.
• W2995476775 countsByYear W29954767752023 @default.
• W2995476775 crossrefType "journal-article" @default.
• W2995476775 hasAuthorship W2995476775A5063256319 @default.
• W2995476775 hasAuthorship W2995476775A5085734264 @default.
• W2995476775 hasBestOaLocation W29954767752 @default.
• W2995476775 hasConcept C126322002 @default.
• W2995476775 hasConcept C134018914 @default.
• W2995476775 hasConcept C159641895 @default.
• W2995476775 hasConcept C2780091579 @default.
• W2995476775 hasConcept C71924100 @default.
• W2995476775 hasConcept C7643261 @default.
• W2995476775 hasConcept C98274493 @default.
• W2995476775 hasConceptScore W2995476775C126322002 @default.
• W2995476775 hasConceptScore W2995476775C134018914 @default.
• W2995476775 hasConceptScore W2995476775C159641895 @default.
• W2995476775 hasConceptScore W2995476775C2780091579 @default.
• W2995476775 hasConceptScore W2995476775C71924100 @default.
• W2995476775 hasConceptScore W2995476775C7643261 @default.
• W2995476775 hasConceptScore W2995476775C98274493 @default.
• W2995476775 hasIssue "2" @default.
• W2995476775 hasLocation W29954767751 @default.
• W2995476775 hasLocation W29954767752 @default.
• W2995476775 hasLocation W29954767753 @default.
• W2995476775 hasOpenAccess W2995476775 @default.
• W2995476775 hasPrimaryLocation W29954767751 @default.
• W2995476775 hasRelatedWork W1980339709 @default.
• W2995476775 hasRelatedWork W2020959757 @default.
• W2995476775 hasRelatedWork W2042033030 @default.
• W2995476775 hasRelatedWork W2044943066 @default.
• W2995476775 hasRelatedWork W2070511355 @default.

• next