FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995514608> ?p ?o ?g. }

• W2995514608 endingPage "26726" @default.
• W2995514608 startingPage "26717" @default.
• W2995514608 abstract "Crohn's disease and ulcerative colitis are chronic and progressive inflammatory bowel diseases (IBDs) that are attributed to dysregulated interactions between the gut microbiome and the intestinal mucosa-associated immune system. There are limited studies investigating the role of either IL-1α or IL-1β in mouse models of colitis, and no clinical trials blocking either IL-1 have yet to be performed. In the present study, we show that neutralization of IL-1α by a specific monoclonal antibody against murine IL-1α was highly effective in reducing inflammation and damage in SAMP mice, mice that spontaneously develop a Crohn's-like ileitis. Anti-mouse IL-1α significantly ameliorated the established, chronic ileitis and also protected mice from developing acute DSS-induced colitis. Both were associated with taxonomic divergence of the fecal gut microbiome, which was treatment-specific and not dependent on inflammation. Anti-IL-1α administration led to a decreased ratio of Proteobacteria to Bacteroidetes, decreased presence of Helicobacter species, and elevated representation of Mucispirillum schaedleri and Lactobacillus salivarius. Such modification in flora was functionally linked to the antiinflammatory effects of IL-1α neutralization, as blockade of IL-1α was not effective in germfree SAMP mice. Furthermore, preemptive dexamethasone treatment of DSS-challenged SAMP mice led to changes in flora composition without preventing the development of colitis. Thus, neutralization of IL-1α changes specific bacterial species of the intestinal microbiome, which is linked to its antiinflammatory effects. These functional findings may be of significant value for patients with IBD, who may benefit from targeted IL-1α-based therapies." @default.
• W2995514608 created "2019-12-26" @default.
• W2995514608 creator A5003025313 @default.
• W2995514608 creator A5004361135 @default.
• W2995514608 creator A5008150296 @default.
• W2995514608 creator A5020447126 @default.
• W2995514608 creator A5028234430 @default.
• W2995514608 creator A5062107175 @default.
• W2995514608 creator A5070485730 @default.
• W2995514608 creator A5078403705 @default.
• W2995514608 creator A5082690566 @default.
• W2995514608 creator A5085124229 @default.
• W2995514608 creator A5091219809 @default.
• W2995514608 date "2019-12-16" @default.
• W2995514608 modified "2023-10-17" @default.
• W2995514608 title "Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome" @default.
• W2995514608 cites W1527106458 @default.
• W2995514608 cites W1531994627 @default.
• W2995514608 cites W1606491845 @default.
• W2995514608 cites W1683363040 @default.
• W2995514608 cites W1868032452 @default.
• W2995514608 cites W1938827771 @default.
• W2995514608 cites W1955424478 @default.
• W2995514608 cites W1967309573 @default.
• W2995514608 cites W1977905067 @default.
• W2995514608 cites W1988107038 @default.
• W2995514608 cites W1989611378 @default.
• W2995514608 cites W1993598111 @default.
• W2995514608 cites W2011199158 @default.
• W2995514608 cites W2019792105 @default.
• W2995514608 cites W2022248283 @default.
• W2995514608 cites W2023731445 @default.
• W2995514608 cites W2024346860 @default.
• W2995514608 cites W2027715226 @default.
• W2995514608 cites W2042851093 @default.
• W2995514608 cites W2056269468 @default.
• W2995514608 cites W2061853512 @default.
• W2995514608 cites W2066268250 @default.
• W2995514608 cites W2066327704 @default.
• W2995514608 cites W2072907428 @default.
• W2995514608 cites W2073878909 @default.
• W2995514608 cites W2082471133 @default.
• W2995514608 cites W2082814058 @default.
• W2995514608 cites W2083849016 @default.
• W2995514608 cites W2096683371 @default.
• W2995514608 cites W2105458866 @default.
• W2995514608 cites W2108373994 @default.
• W2995514608 cites W2115524426 @default.
• W2995514608 cites W2118983602 @default.
• W2995514608 cites W2125448515 @default.
• W2995514608 cites W2146102642 @default.
• W2995514608 cites W2150481989 @default.
• W2995514608 cites W2151159966 @default.
• W2995514608 cites W2152751713 @default.
• W2995514608 cites W2152759011 @default.
• W2995514608 cites W2155719764 @default.
• W2995514608 cites W2168652736 @default.
• W2995514608 cites W2201859789 @default.
• W2995514608 cites W2270296717 @default.
• W2995514608 cites W2486235357 @default.
• W2995514608 cites W2498839525 @default.
• W2995514608 cites W2513322257 @default.
• W2995514608 cites W2572024892 @default.
• W2995514608 cites W2578250538 @default.
• W2995514608 cites W2584866430 @default.
• W2995514608 cites W2748400555 @default.
• W2995514608 cites W2755548020 @default.
• W2995514608 cites W2767737860 @default.
• W2995514608 cites W2769664962 @default.
• W2995514608 cites W2778416039 @default.
• W2995514608 cites W2790920611 @default.
• W2995514608 cites W2792385423 @default.
• W2995514608 cites W2794377080 @default.
• W2995514608 cites W2803007676 @default.
• W2995514608 cites W2884033636 @default.
• W2995514608 cites W2890871359 @default.
• W2995514608 cites W2925646196 @default.
• W2995514608 doi "https://doi.org/10.1073/pnas.1915043116" @default.
• W2995514608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6936591" @default.
• W2995514608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31843928" @default.
• W2995514608 hasPublicationYear "2019" @default.
• W2995514608 type Work @default.
• W2995514608 sameAs 2995514608 @default.
• W2995514608 citedByCount "37" @default.
• W2995514608 countsByYear W29955146082020 @default.
• W2995514608 countsByYear W29955146082021 @default.
• W2995514608 countsByYear W29955146082022 @default.
• W2995514608 countsByYear W29955146082023 @default.
• W2995514608 crossrefType "journal-article" @default.
• W2995514608 hasAuthorship W2995514608A5003025313 @default.
• W2995514608 hasAuthorship W2995514608A5004361135 @default.
• W2995514608 hasAuthorship W2995514608A5008150296 @default.
• W2995514608 hasAuthorship W2995514608A5020447126 @default.
• W2995514608 hasAuthorship W2995514608A5028234430 @default.
• W2995514608 hasAuthorship W2995514608A5062107175 @default.
• W2995514608 hasAuthorship W2995514608A5070485730 @default.
• W2995514608 hasAuthorship W2995514608A5078403705 @default.
• W2995514608 hasAuthorship W2995514608A5082690566 @default.

• next