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• W2995526385 abstract "Abstract Objective We wished to determine bone alterations in systemic sclerosis (SSc) patients by conventional densitometry (DXA), peripheral quantitative computed tomography (pQCT), and bone biomarkers. Methods We included 44 SSc patients and 33 age-matched healthy controls. Lumbar spine and femoral neck bone mineral density (BMD) was assessed by DXA. Volumetric BMD was measured by pQCT at the radius. FRAX, 25-hydroxyvitamin-D 3 (25-OH-D 3 ), parathyroid hormone, osteocalcin, C-terminal collagen telopeptide, and procollagen type I amino-terminal propeptide were also assessed. Results SSc patients had lower L2–4 BMD (0.880 ± 0.108 vs. 0.996 ± 0.181 g/cm 2 ; p = 0.019) and femoral neck (FN) BMD (0.786 ± 0.134 vs. 0.910 ± 0.090 g/cm 2 ; p = 0.007) by DXA. In SSc vs. controls, pQCT indicated lower mean cortical (328.03 ± 103.32 vs. 487.06 ± 42.45 mg/cm 3 ; p < 0.001) and trabecular density (150.93 ± 61.91 vs. 184.76 ± 33.03 mg/cm 3 ; p = 0.037). Vitamin D 3 deficiency was more common in SSc vs. controls (60.0% vs. 39.3%; p = 0.003). L2–4 ( p = 0.002) and FN BMD ( p = 0.015) positively correlated with BMI. pQCT assessments confirmed an inverse correlation between pulmonary manifestation and total ( p = 0.024), trabecular ( p = 0.035), and cortical density ( p = 0.015). Anti-Scl70 positivity inversely correlated with pQCT total density ( p = 0.015) and the presence of digital ulcers with cortical density ( p = 0.001). We also found that vertebral and FN BMD as determined by DXA significantly correlated with pQCT total, trabecular, and cortical density ( p < 0.05). Conclusion The results of our study suggest that bone loss in SSc patients may be associated with lower BMI, anti-Scl70 positivity, and the presence of pulmonary manifestations and digital ulcers. Both DXA and pQCT are appropriate tools to evaluate the bone alterations in SSc patients." @default.
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• W2995526385 date "2019-12-01" @default.
• W2995526385 modified "2023-10-17" @default.
• W2995526385 title "Complex assessment of bone mineral density, fracture risk, vitamin D status, and bone metabolism in Hungarian systemic sclerosis patients" @default.
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• W2995526385 doi "https://doi.org/10.1186/s13075-019-2072-y" @default.
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