Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995528130> ?p ?o ?g. }
- W2995528130 endingPage "82" @default.
- W2995528130 startingPage "72" @default.
- W2995528130 abstract "The aquaculture system based on biofloc technology (BFT) showed positive effects on prevention of Cyprinid herpesvirus 2 (CyHV-2) infection in gibel carp (Carassius auratus gibelio), which is detrimental to health and causes seriously economic losses to aquaculture. However, the enhancement mechanism of BFT regarding immunity and disease resistance of cultured species is scarce. Poly-β-hydroxybutyrate (PHB) has been proved as one of bioactive compounds in bioflocs. In this study, two groups (4% PHB supplementation diets and control with basal diets) with 30-day feeding were set to study the effect of PHB supplementation on immune-related gene expression by qRT-PCR, time-course CyHV-2 replication in vivo by qPCR and intestinal microbiota by illumine high-throughput sequencing. PHB supplementation significantly up-regulated transcriptional levels of eight immune-related genes, decreased cumulative mortality of gibel carp and early CyHV-2 replication in spleen in vivo (P < 0.05). Additionally, PHB changed the microbial structure but not diversity, and significantly increased beneficial bacteria such as Bacillus sp. KEGG pathway analysis by PICRUSt demonstrated that oral administration of PHB up-regulated abundances of genes responsible for seven pathways and down-regulated genes in eleven pathways. Histological structures of foregut, mindgut and hindgut were also affected. Our findings suggested that profitable effects of PHB on immunity and disease resistance might be gut microbiota-related, and regulated through pathways of enzymes secretion, replication and repair, and host immune system. This study will provide new insights into understanding the enhancing mechanism of BFT on immunity and disease resistance of cultured animals, and developing prebiotics/probiotics-based immunotherapies to improve animal health and disease resistance." @default.
- W2995528130 created "2019-12-26" @default.
- W2995528130 creator A5002755011 @default.
- W2995528130 creator A5003631389 @default.
- W2995528130 creator A5010444377 @default.
- W2995528130 creator A5010755344 @default.
- W2995528130 creator A5039728001 @default.
- W2995528130 creator A5069771802 @default.
- W2995528130 creator A5090272902 @default.
- W2995528130 date "2020-02-01" @default.
- W2995528130 modified "2023-10-15" @default.
- W2995528130 title "Poly-β-hydroxybutyrate (PHB) in bioflocs alters intestinal microbial community structure, immune-related gene expression and early Cyprinid herpesvirus 2 replication in gibel carp (Carassius auratus gibelio)" @default.
- W2995528130 cites W1490563112 @default.
- W2995528130 cites W1602549455 @default.
- W2995528130 cites W1962398740 @default.
- W2995528130 cites W1970394698 @default.
- W2995528130 cites W1982419884 @default.
- W2995528130 cites W1996031685 @default.
- W2995528130 cites W1996253845 @default.
- W2995528130 cites W1997039338 @default.
- W2995528130 cites W1999373531 @default.
- W2995528130 cites W2005355610 @default.
- W2995528130 cites W2006535751 @default.
- W2995528130 cites W2015332978 @default.
- W2995528130 cites W2025313960 @default.
- W2995528130 cites W2026911719 @default.
- W2995528130 cites W2034311019 @default.
- W2995528130 cites W2044578083 @default.
- W2995528130 cites W2054600990 @default.
- W2995528130 cites W2054779029 @default.
- W2995528130 cites W2060412085 @default.
- W2995528130 cites W2062934605 @default.
- W2995528130 cites W2066369040 @default.
- W2995528130 cites W2081380654 @default.
- W2995528130 cites W2090234656 @default.
- W2995528130 cites W2103951513 @default.
- W2995528130 cites W2107277218 @default.
- W2995528130 cites W2110300022 @default.
- W2995528130 cites W2118880026 @default.
- W2995528130 cites W2129445060 @default.
- W2995528130 cites W2131073826 @default.
- W2995528130 cites W2133856765 @default.
- W2995528130 cites W2144020966 @default.
- W2995528130 cites W2144434695 @default.
- W2995528130 cites W2149202898 @default.
- W2995528130 cites W2154308883 @default.
- W2995528130 cites W2156304954 @default.
- W2995528130 cites W2158389310 @default.
- W2995528130 cites W2158683791 @default.
- W2995528130 cites W2164469996 @default.
- W2995528130 cites W2166680877 @default.
- W2995528130 cites W2171970315 @default.
- W2995528130 cites W2190567753 @default.
- W2995528130 cites W2316272389 @default.
- W2995528130 cites W2552673729 @default.
- W2995528130 cites W2589742778 @default.
- W2995528130 cites W2755782805 @default.
- W2995528130 cites W2772497532 @default.
- W2995528130 cites W2772599266 @default.
- W2995528130 cites W2793356262 @default.
- W2995528130 cites W2794470016 @default.
- W2995528130 cites W2803794486 @default.
- W2995528130 cites W2888508652 @default.
- W2995528130 cites W2892311007 @default.
- W2995528130 cites W2897484933 @default.
- W2995528130 cites W2946608058 @default.
- W2995528130 doi "https://doi.org/10.1016/j.fsi.2019.12.045" @default.
- W2995528130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31846772" @default.
- W2995528130 hasPublicationYear "2020" @default.
- W2995528130 type Work @default.
- W2995528130 sameAs 2995528130 @default.
- W2995528130 citedByCount "32" @default.
- W2995528130 countsByYear W29955281302020 @default.
- W2995528130 countsByYear W29955281302021 @default.
- W2995528130 countsByYear W29955281302022 @default.
- W2995528130 countsByYear W29955281302023 @default.
- W2995528130 crossrefType "journal-article" @default.
- W2995528130 hasAuthorship W2995528130A5002755011 @default.
- W2995528130 hasAuthorship W2995528130A5003631389 @default.
- W2995528130 hasAuthorship W2995528130A5010444377 @default.
- W2995528130 hasAuthorship W2995528130A5010755344 @default.
- W2995528130 hasAuthorship W2995528130A5039728001 @default.
- W2995528130 hasAuthorship W2995528130A5069771802 @default.
- W2995528130 hasAuthorship W2995528130A5090272902 @default.
- W2995528130 hasConcept C104317684 @default.
- W2995528130 hasConcept C150194340 @default.
- W2995528130 hasConcept C152724338 @default.
- W2995528130 hasConcept C162317418 @default.
- W2995528130 hasConcept C203014093 @default.
- W2995528130 hasConcept C2778891732 @default.
- W2995528130 hasConcept C2779341262 @default.
- W2995528130 hasConcept C2909208804 @default.
- W2995528130 hasConcept C505870484 @default.
- W2995528130 hasConcept C54355233 @default.
- W2995528130 hasConcept C86803240 @default.
- W2995528130 hasConcept C8891405 @default.
- W2995528130 hasConcept C89423630 @default.
- W2995528130 hasConceptScore W2995528130C104317684 @default.