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• W2995575247 abstract "L’infection congénitale à cytomégalovirus (CMV) est diagnostiquée soit pendant la vie fœtale sur des signes d’appel échographiques ou sur la notion d’une primo infection maternelle, soit devant une symptomatologie néonatale évocatrice. Les facteurs prédictifs de séquelles neurosensorielles sont l’âge gestationnel de la contamination fœtale, la présence de signes cliniques néonatals et les données de l’imagerie cérébrale ante et néonatale. Les séquelles neurosensorielles concernent 60 % des nouveau-nés symptomatiques et 15 % des asymptomatiques. Il s’agit, par ordre de fréquence, de déficit auditif, troubles vestibulaires, infirmité motrice, déficit visuel, déficit cognitif, troubles du comportement. La possibilité d’apparition secondaire d’un déficit auditif justifie la surveillance systématique des nouveau-nés infectés jusqu’à l’âge de 4 à 7 ans. Beaucoup d’inconnues persistent sur les indications et le bénéfice attendu du traitement antiviral par (val)ganciclovir. Congenital cytomegalovirus (CMV) infection is diagnosed either antenatally on echographic presenting symptoms or on the background of primary infection in the mother, or in front of a suggestive neonatal symptomatology. Predictive factors for neurosensory sequelae include gestational age of fetal infection, whether neonatal clinical signs are present or not, and data from antenatal and neonatal brain imaging. Neurosensory sequelae occur in 60% of symptomatic and 15% of asymptomatic newborns. These include, in order of frequency, hearing impairment, vestibular disorders, visual impairment, cerebral palsy, cognitive impairment and autism spectrum disorders. The possibility of delayed onset hearing loss warrants prolonged monitoring of the children up to the age of 4 to 6 years. Many unknowns persist on the indications and expected benefit of antiviral treatment with Ganciclovir." @default.
• W2995575247 created "2019-12-26" @default.
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• W2995575247 date "2020-02-01" @default.
• W2995575247 modified "2023-09-27" @default.
• W2995575247 title "Devenir et prise en charge du nouveau-né infecté par le cytomégalovirus" @default.
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• W2995575247 doi "https://doi.org/10.1016/j.banm.2019.10.022" @default.
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