Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995590704> ?p ?o ?g. }
- W2995590704 endingPage "100673" @default.
- W2995590704 startingPage "100673" @default.
- W2995590704 abstract "Chemotherapy continues to be a major treatment strategy for various human malignancies. However, the frequent emergence of chemoresistance compromises chemotherapy efficacy leading to poor prognosis. Thus, overcoming drug resistance is pivotal to achieve enhanced therapy efficacy in various cancers. Although increased evidence has revealed that reduced drug uptake, increased drug efflux, drug target protein alterations, drug sequestration in organelles, enhanced drug metabolism, impaired DNA repair systems, and anti-apoptotic mechanisms, are critically involved in drug resistance, the detailed resistance mechanisms have not been fully elucidated in distinct cancers. Recently, F-box protein (FBPs), key subunits in Skp1-Cullin1-F-box protein (SCF) E3 ligase complexes, have been found to play critical roles in carcinogenesis, tumor progression, and drug resistance through degradation of their downstream substrates. Therefore, in this review, we describe the functions of FBPs that are involved in drug resistance and discuss how FBPs contribute to the development of cancer drug resistance. Furthermore, we propose that targeting FBPs might be a promising strategy to overcome drug resistance and achieve better treatment outcome in cancer patients. Lastly, we state the limitations and challenges of using FBPs to overcome chemotherapeutic drug resistance in various cancers." @default.
- W2995590704 created "2019-12-26" @default.
- W2995590704 creator A5013852274 @default.
- W2995590704 creator A5023127724 @default.
- W2995590704 creator A5029006458 @default.
- W2995590704 creator A5032131879 @default.
- W2995590704 creator A5059910582 @default.
- W2995590704 creator A5063701979 @default.
- W2995590704 date "2020-03-01" @default.
- W2995590704 modified "2023-10-02" @default.
- W2995590704 title "Emerging roles of F-box proteins in cancer drug resistance" @default.
- W2995590704 cites W1132077651 @default.
- W2995590704 cites W1545013699 @default.
- W2995590704 cites W1589369501 @default.
- W2995590704 cites W1589711911 @default.
- W2995590704 cites W1824828093 @default.
- W2995590704 cites W1842332008 @default.
- W2995590704 cites W1923957717 @default.
- W2995590704 cites W1927394523 @default.
- W2995590704 cites W1959775384 @default.
- W2995590704 cites W1963617699 @default.
- W2995590704 cites W1963987641 @default.
- W2995590704 cites W1964790920 @default.
- W2995590704 cites W1965692834 @default.
- W2995590704 cites W1973631495 @default.
- W2995590704 cites W1975472671 @default.
- W2995590704 cites W1977416705 @default.
- W2995590704 cites W1978089688 @default.
- W2995590704 cites W1978735501 @default.
- W2995590704 cites W1981369902 @default.
- W2995590704 cites W1984545450 @default.
- W2995590704 cites W1987821813 @default.
- W2995590704 cites W1989179062 @default.
- W2995590704 cites W1990983360 @default.
- W2995590704 cites W1995565630 @default.
- W2995590704 cites W1998589450 @default.
- W2995590704 cites W1999459611 @default.
- W2995590704 cites W2000668038 @default.
- W2995590704 cites W2005143921 @default.
- W2995590704 cites W2006850044 @default.
- W2995590704 cites W2007091540 @default.
- W2995590704 cites W2013199516 @default.
- W2995590704 cites W2019412207 @default.
- W2995590704 cites W2022639530 @default.
- W2995590704 cites W2022648591 @default.
- W2995590704 cites W2023040745 @default.
- W2995590704 cites W2025246434 @default.
- W2995590704 cites W2027182048 @default.
- W2995590704 cites W2028791725 @default.
- W2995590704 cites W2037152390 @default.
- W2995590704 cites W2037548653 @default.
- W2995590704 cites W2039193100 @default.
- W2995590704 cites W2041105463 @default.
- W2995590704 cites W2044182846 @default.
- W2995590704 cites W2045329567 @default.
- W2995590704 cites W2047868774 @default.
- W2995590704 cites W2050962273 @default.
- W2995590704 cites W2053911973 @default.
- W2995590704 cites W2058070883 @default.
- W2995590704 cites W2059321345 @default.
- W2995590704 cites W2060876398 @default.
- W2995590704 cites W2061909885 @default.
- W2995590704 cites W2062124403 @default.
- W2995590704 cites W2066364577 @default.
- W2995590704 cites W2067131610 @default.
- W2995590704 cites W2068633034 @default.
- W2995590704 cites W2068907918 @default.
- W2995590704 cites W2071337607 @default.
- W2995590704 cites W2079023822 @default.
- W2995590704 cites W2082018870 @default.
- W2995590704 cites W2086377914 @default.
- W2995590704 cites W2088485356 @default.
- W2995590704 cites W2090375541 @default.
- W2995590704 cites W2090453777 @default.
- W2995590704 cites W2091798601 @default.
- W2995590704 cites W2092138220 @default.
- W2995590704 cites W2095357232 @default.
- W2995590704 cites W2105323766 @default.
- W2995590704 cites W2105508436 @default.
- W2995590704 cites W2105605511 @default.
- W2995590704 cites W2108672601 @default.
- W2995590704 cites W2109079322 @default.
- W2995590704 cites W2111216934 @default.
- W2995590704 cites W2111394514 @default.
- W2995590704 cites W2113634596 @default.
- W2995590704 cites W2114402036 @default.
- W2995590704 cites W2116965161 @default.
- W2995590704 cites W2117692326 @default.
- W2995590704 cites W2118775295 @default.
- W2995590704 cites W2125459645 @default.
- W2995590704 cites W2128987620 @default.
- W2995590704 cites W2130983930 @default.
- W2995590704 cites W2131182830 @default.
- W2995590704 cites W2131489806 @default.
- W2995590704 cites W2134055001 @default.
- W2995590704 cites W2134555649 @default.
- W2995590704 cites W2139030085 @default.
- W2995590704 cites W2139244380 @default.