FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995607900> ?p ?o ?g. }

• W2995607900 abstract "Abstract The genetic architecture of complex human traits remains largely unknown. The distribution of heritability across the minor allele frequency (MAF) spectrum for a trait will be a function of the MAF of its causal variants and their effect sizes. Assumptions about these relationships underpin the tools used to estimate heritability. We examine the performance of two widely used tools, Haseman-Elston (HE) Regression and genomic-relatedness-based restricted maximum-likelihood (GREML). Our simulations show that HE is less biased than GREML under a wide variety of models and that the estimated standard error for HE tends to be substantially overestimated. We then applied HE Regression to infer the heritability of 72 quantitative biomedical traits from up to 50,000 individuals with genotype and imputation data from the UK Biobank. We found that adding each individuals’ geolocation as covariates corrected for population stratification that could not be accounted for by principal components alone (particularly for rare variants). The biomedical traits we analyzed had an average heritability of 0.27, with low frequency variants (MAF≤0.05) explaining an average of 47.7% of the total heritability (and lower frequency variants with MAF≤0.02 explaining a majority of our increased heritability over previous estimates). Variants in regions of low linkage disequilibrium (LD) accounted for 3.3-fold more heritability than the variants in regions of high LD, an effect primarily driven by low frequency variants. These findings suggest a moderate action of negative selection on the causal variants of these traits." @default.
• W2995607900 created "2019-12-26" @default.
• W2995607900 creator A5005352234 @default.
• W2995607900 creator A5035070420 @default.
• W2995607900 creator A5044803063 @default.
• W2995607900 creator A5084656451 @default.
• W2995607900 date "2019-12-19" @default.
• W2995607900 modified "2023-10-17" @default.
• W2995607900 title "Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits" @default.
• W2995607900 cites W1844405070 @default.
• W2995607900 cites W1964511379 @default.
• W2995607900 cites W1977104259 @default.
• W2995607900 cites W1983539381 @default.
• W2995607900 cites W1992436001 @default.
• W2995607900 cites W1994975196 @default.
• W2995607900 cites W2027044503 @default.
• W2995607900 cites W2031090940 @default.
• W2995607900 cites W2033151532 @default.
• W2995607900 cites W2038522196 @default.
• W2995607900 cites W2043277040 @default.
• W2995607900 cites W2070589766 @default.
• W2995607900 cites W2106294125 @default.
• W2995607900 cites W2115193738 @default.
• W2995607900 cites W2129559300 @default.
• W2995607900 cites W2139852278 @default.
• W2995607900 cites W2146415150 @default.
• W2995607900 cites W2155496693 @default.
• W2995607900 cites W2161633633 @default.
• W2995607900 cites W2181596174 @default.
• W2995607900 cites W2188707104 @default.
• W2995607900 cites W2213573197 @default.
• W2995607900 cites W2229599978 @default.
• W2995607900 cites W2511515754 @default.
• W2995607900 cites W2578636028 @default.
• W2995607900 cites W2617742891 @default.
• W2995607900 cites W2626606138 @default.
• W2995607900 cites W2757581422 @default.
• W2995607900 cites W2797293309 @default.
• W2995607900 cites W2798750837 @default.
• W2995607900 cites W2892391774 @default.
• W2995607900 cites W2895486342 @default.
• W2995607900 cites W2901957554 @default.
• W2995607900 cites W2921062076 @default.
• W2995607900 cites W2923424663 @default.
• W2995607900 cites W2951427191 @default.
• W2995607900 cites W2952882474 @default.
• W2995607900 cites W2953134354 @default.
• W2995607900 cites W2970142068 @default.
• W2995607900 cites W2975535587 @default.
• W2995607900 cites W2979220318 @default.
• W2995607900 doi "https://doi.org/10.1101/2019.12.18.879916" @default.
• W2995607900 hasPublicationYear "2019" @default.
• W2995607900 type Work @default.
• W2995607900 sameAs 2995607900 @default.
• W2995607900 citedByCount "5" @default.
• W2995607900 countsByYear W29956079002021 @default.
• W2995607900 countsByYear W29956079002022 @default.
• W2995607900 crossrefType "posted-content" @default.
• W2995607900 hasAuthorship W2995607900A5005352234 @default.
• W2995607900 hasAuthorship W2995607900A5035070420 @default.
• W2995607900 hasAuthorship W2995607900A5044803063 @default.
• W2995607900 hasAuthorship W2995607900A5084656451 @default.
• W2995607900 hasBestOaLocation W29956079001 @default.
• W2995607900 hasConcept C104317684 @default.
• W2995607900 hasConcept C105795698 @default.
• W2995607900 hasConcept C106934330 @default.
• W2995607900 hasConcept C135763542 @default.
• W2995607900 hasConcept C144024400 @default.
• W2995607900 hasConcept C144621757 @default.
• W2995607900 hasConcept C149923435 @default.
• W2995607900 hasConcept C153209595 @default.
• W2995607900 hasConcept C157410074 @default.
• W2995607900 hasConcept C161890455 @default.
• W2995607900 hasConcept C166976648 @default.
• W2995607900 hasConcept C199360897 @default.
• W2995607900 hasConcept C2908647359 @default.
• W2995607900 hasConcept C2993967602 @default.
• W2995607900 hasConcept C33923547 @default.
• W2995607900 hasConcept C35605836 @default.
• W2995607900 hasConcept C37463918 @default.
• W2995607900 hasConcept C41008148 @default.
• W2995607900 hasConcept C54355233 @default.
• W2995607900 hasConcept C58041806 @default.
• W2995607900 hasConcept C68873052 @default.
• W2995607900 hasConcept C70616004 @default.
• W2995607900 hasConcept C81941488 @default.
• W2995607900 hasConcept C83546350 @default.
• W2995607900 hasConcept C86803240 @default.
• W2995607900 hasConcept C9287583 @default.
• W2995607900 hasConcept C9357733 @default.
• W2995607900 hasConceptScore W2995607900C104317684 @default.
• W2995607900 hasConceptScore W2995607900C105795698 @default.
• W2995607900 hasConceptScore W2995607900C106934330 @default.
• W2995607900 hasConceptScore W2995607900C135763542 @default.
• W2995607900 hasConceptScore W2995607900C144024400 @default.
• W2995607900 hasConceptScore W2995607900C144621757 @default.
• W2995607900 hasConceptScore W2995607900C149923435 @default.
• W2995607900 hasConceptScore W2995607900C153209595 @default.
• W2995607900 hasConceptScore W2995607900C157410074 @default.
• W2995607900 hasConceptScore W2995607900C161890455 @default.

• next