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• W2995627840 abstract "Abstract Novel tools for early diagnosis and monitoring of schistosomiasis are urgently needed. This study aimed to validate parasite-derived miRNAs as potential novel biomarkers for the detection of human Schistosoma japonicum infection. A total of 21 miRNAs were initially validated by real-time-polymerase chain reaction (RT-PCR) using serum samples of S. japonicum -infected BALB/c mice. Of these, 6 miRNAs were further validated with a human cohort of individuals from a schistosomiasis-endemic area of the Philippines. RT-PCR analysis showed that two parasite-derived miRNAs (sja-miR-2b-5p and sja-miR-2c-5p) could detect infected individuals with low infection intensity with moderate sensitivity/specificity values of 66%/68% and 55%/80%, respectively. Analysis of the combined data for the two parasite miRNAs revealed a specificity of 77.4% and a sensitivity of 60.0% with an area under the curve (AUC) value of 0.6906 ( P = 0.0069); however, a duplex RT-PCR targeting both sja-miR-2b-5p and sja-miR-2c-5p did not result in an increased diagnostic performance compared with the singleplex assays. Furthermore, the serum level of sja-miR-2c-5p correlated significantly with faecal egg counts, whereas the other five miRNAs did not. Targeting S. japonicum -derived miRNAs in serum resulted in a moderate diagnostic performance when applied to a low schistosome infection intensity setting." @default.
• W2995627840 created "2019-12-26" @default.
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• W2995627840 date "2019-12-16" @default.
• W2995627840 modified "2023-09-30" @default.
• W2995627840 title "Parasite-derived circulating microRNAs as biomarkers for the detection of human <i>Schistosoma japonicum</i> infection" @default.
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• W2995627840 doi "https://doi.org/10.1017/s0031182019001690" @default.
• W2995627840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7391863" @default.
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