FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995638049> ?p ?o ?g. }

• W2995638049 endingPage "6249" @default.
• W2995638049 startingPage "6249" @default.
• W2995638049 abstract "MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation. The outcome of a myriad of physiological processes and pathologies, including cancer, cardiovascular and metabolic diseases, relies highly on miRNAs. However, deciphering the precise roles of specific miRNAs in these pathophysiological contexts is challenging due to the high levels of complexity of their actions. Indeed, regulation of mRNA expression by miRNAs is frequently cell/organ specific; highly dependent on the stress and metabolic status of the organism; and often poorly correlated with miRNA expression levels. Such biological features of miRNAs suggest that various regulatory mechanisms control not only their expression, but also their activity and/or bioavailability. Several mechanisms have been described to modulate miRNA action, including genetic polymorphisms, methylation of miRNA promoters, asymmetric miRNA strand selection, interactions with RNA-binding proteins (RBPs) or other coding/non-coding RNAs. Moreover, nucleotide modifications (A-to-I or C-to-U) within the miRNA sequences at different stages of their maturation are also critical for their functionality. This regulatory mechanism called RNA editing involves specific enzymes of the adenosine/cytidine deaminase family, which trigger single nucleotide changes in primary miRNAs. These nucleotide modifications greatly influence a miRNA's stability, maturation and activity by changing its specificity towards target mRNAs. Understanding how editing events impact miRNA's ability to regulate stress responses in cells and organs, or the development of specific pathologies, e.g., metabolic diseases or cancer, should not only deepen our knowledge of molecular mechanisms underlying complex diseases, but can also facilitate the design of new therapeutic approaches based on miRNA targeting. Herein, we will discuss the current knowledge on miRNA editing and how this mechanism regulates miRNA biogenesis and activity." @default.
• W2995638049 created "2019-12-26" @default.
• W2995638049 creator A5004200954 @default.
• W2995638049 creator A5027231558 @default.
• W2995638049 creator A5049015949 @default.
• W2995638049 creator A5055107714 @default.
• W2995638049 creator A5081625627 @default.
• W2995638049 date "2019-12-11" @default.
• W2995638049 modified "2023-10-14" @default.
• W2995638049 title "Deciphering miRNAs’ Action through miRNA Editing" @default.
• W2995638049 cites W1567625470 @default.
• W2995638049 cites W1615061161 @default.
• W2995638049 cites W1977499057 @default.
• W2995638049 cites W1982079498 @default.
• W2995638049 cites W1982163838 @default.
• W2995638049 cites W1985126922 @default.
• W2995638049 cites W1986272738 @default.
• W2995638049 cites W1987208099 @default.
• W2995638049 cites W1990430076 @default.
• W2995638049 cites W1993324234 @default.
• W2995638049 cites W1997393600 @default.
• W2995638049 cites W1999361121 @default.
• W2995638049 cites W2001416012 @default.
• W2995638049 cites W2013132763 @default.
• W2995638049 cites W2013733230 @default.
• W2995638049 cites W2014127990 @default.
• W2995638049 cites W2018146396 @default.
• W2995638049 cites W2022490671 @default.
• W2995638049 cites W2028423947 @default.
• W2995638049 cites W2029728313 @default.
• W2995638049 cites W2029917941 @default.
• W2995638049 cites W2033867175 @default.
• W2995638049 cites W2034040854 @default.
• W2995638049 cites W2037786477 @default.
• W2995638049 cites W2040290488 @default.
• W2995638049 cites W2049660571 @default.
• W2995638049 cites W2056573404 @default.
• W2995638049 cites W2057549495 @default.
• W2995638049 cites W2058809590 @default.
• W2995638049 cites W2059439438 @default.
• W2995638049 cites W2060083739 @default.
• W2995638049 cites W2060379087 @default.
• W2995638049 cites W2062254583 @default.
• W2995638049 cites W2069009920 @default.
• W2995638049 cites W2075863097 @default.
• W2995638049 cites W2077280260 @default.
• W2995638049 cites W2079141739 @default.
• W2995638049 cites W2079371587 @default.
• W2995638049 cites W2080636764 @default.
• W2995638049 cites W2087354672 @default.
• W2995638049 cites W2089001345 @default.
• W2995638049 cites W2090697236 @default.
• W2995638049 cites W2092030071 @default.
• W2995638049 cites W2092310019 @default.
• W2995638049 cites W2096335988 @default.
• W2995638049 cites W2098365915 @default.
• W2995638049 cites W2099009731 @default.
• W2995638049 cites W2103328194 @default.
• W2995638049 cites W2103350275 @default.
• W2995638049 cites W2104212643 @default.
• W2995638049 cites W2106077004 @default.
• W2995638049 cites W2108102772 @default.
• W2995638049 cites W2116679407 @default.
• W2995638049 cites W2123265753 @default.
• W2995638049 cites W2127365846 @default.
• W2995638049 cites W2133123387 @default.
• W2995638049 cites W2135006644 @default.
• W2995638049 cites W2138501360 @default.
• W2995638049 cites W2138664009 @default.
• W2995638049 cites W2144522989 @default.
• W2995638049 cites W2149209099 @default.
• W2995638049 cites W2154349943 @default.
• W2995638049 cites W2156089250 @default.
• W2995638049 cites W2157370528 @default.
• W2995638049 cites W2162277004 @default.
• W2995638049 cites W2162437811 @default.
• W2995638049 cites W2162674813 @default.
• W2995638049 cites W2171597027 @default.
• W2995638049 cites W2171619292 @default.
• W2995638049 cites W2172549233 @default.
• W2995638049 cites W2173666904 @default.
• W2995638049 cites W2193739999 @default.
• W2995638049 cites W2216943200 @default.
• W2995638049 cites W2222280977 @default.
• W2995638049 cites W2245182541 @default.
• W2995638049 cites W2302134707 @default.
• W2995638049 cites W2303848959 @default.
• W2995638049 cites W2391969373 @default.
• W2995638049 cites W2398347999 @default.
• W2995638049 cites W2410092046 @default.
• W2995638049 cites W2410097241 @default.
• W2995638049 cites W2426748474 @default.
• W2995638049 cites W2470212121 @default.
• W2995638049 cites W2512481987 @default.
• W2995638049 cites W2526406351 @default.
• W2995638049 cites W2530597079 @default.
• W2995638049 cites W2550790189 @default.
• W2995638049 cites W2564196056 @default.

• next