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- W2995698370 abstract "This review focuses on mechanisms of calorie restriction (CR), particularly the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal that regulates aging and lifespan, underlying the effects of CR in mammals. Topics include (1) the relation of the GH-IGF-1 signal with chronic low-level inflammation as one of the possible causative factors of aging, that is, inflammaging, (2) the isoform specificity of the forkhead box protein O (FoxO) transcription factors in CR-mediated regulation of cancer and lifespan, (3) the role for FoxO1 in the tumor-inhibiting effect of CR, (4) pleiotropic roles for FoxO1 in the regulation of disorders, and (5) sirtuin (Sirt) as a molecule upstream of FoxO. From the evolutionary view, the necessity of neuropeptide Y (Npy) for the effects of CR and the pleiotropic roles for Npy in life stages are also emphasized. Genes for mediating the effects of CR and regulating aging are context-dependent, particularly depending on nutritional states." @default.
- W2995698370 created "2019-12-26" @default.
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- W2995698370 date "2019-12-16" @default.
- W2995698370 modified "2023-10-16" @default.
- W2995698370 title "Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction" @default.
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- W2995698370 doi "https://doi.org/10.3390/nu11123068" @default.
- W2995698370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6950657" @default.
- W2995698370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31888201" @default.
- W2995698370 hasPublicationYear "2019" @default.
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