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• W2995700911 abstract "In people living with HIV (PLWH) on suppressive ART, latent HIV can be found in a diverse range of CD4 + T cells, including quiescent naive and central memory cells that are typically difficult to infect in vitro . It is currently unclear how latency is established in these cells in vivo . We show that in CD4 + T cells from PLWH on suppressive ART, the use of the coreceptor CXCR4 was prevalent among viruses amplified from naive and central memory CD4 + T cells. Furthermore, we found that expanded numbers of identical viral sequences were most common in the effector memory population, and these identical sequences were also found in multiple different CD4 + T cell subsets. Our results help to shed light on how a range of CD4 + T cell subsets come to harbor HIV DNA, which is one of the major barriers to eradicating the virus from PLWH." @default.
• W2995700911 created "2019-12-26" @default.
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• W2995700911 date "2020-02-28" @default.
• W2995700911 modified "2023-09-28" @default.
• W2995700911 title "CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4 ⁺ T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained" @default.
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• W2995700911 doi "https://doi.org/10.1128/jvi.01736-19" @default.
• W2995700911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7158712" @default.
• W2995700911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31852784" @default.
• W2995700911 hasPublicationYear "2020" @default.
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