FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995755001> ?p ?o ?g. }

• W2995755001 endingPage "735" @default.
• W2995755001 startingPage "720" @default.
• W2995755001 abstract "Abstract Drug addiction may be a goal-directed choice driven by excessive drug value in negative affective states, a habit driven by strong stimulus−response associations, or a compulsion driven by insensitivity to costs imposed on drug seeking. Laboratory animal and human evidence for these three theories is evaluated. Excessive goal theory is supported by dependence severity being associated with greater drug choice/economic demand. Drug choice is demonstrably goal-directed (driven by the expected value of the drug) and can be augmented by stress/negative mood induction and withdrawal—effects amplified in those with psychiatric symptoms and drug use coping motives. Furthermore, psychiatric symptoms confer risk of dependence, and coping motives mediate this risk. Habit theory of addiction has weaker support. Habitual behaviour seen in drug-exposed animals often does not occur in complex decision scenarios, or where responding is rewarded, so habit is unlikely to explain most human addictive behaviour where these conditions apply. Furthermore, most human studies have not found greater propensity to habitual behaviour in drug users or as a function of dependence severity, and the minority that have can be explained by task disengagement producing impaired explicit contingency knowledge. Compulsion theory of addiction also has weak support. The persistence of punished drug seeking in animals is better explained by greater drug value (evinced by the association with economic demand) than by insensitivity to costs. Furthermore, human studies have provided weak evidence that propensity to discount cost imposed on drug seeking is associated with dependence severity. These data suggest that human addiction is primarily driven by excessive goal-directed drug choice under negative affect, and less by habit or compulsion. Addiction is pathological because negative states powerfully increase expected drug value acutely outweighing abstinence goals." @default.
• W2995755001 created "2019-12-26" @default.
• W2995755001 creator A5037419542 @default.
• W2995755001 date "2020-01-06" @default.
• W2995755001 modified "2023-10-09" @default.
• W2995755001 title "Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory" @default.
• W2995755001 cites W1534698081 @default.
• W2995755001 cites W1554178914 @default.
• W2995755001 cites W1586646554 @default.
• W2995755001 cites W1698667854 @default.
• W2995755001 cites W1710818377 @default.
• W2995755001 cites W1759494822 @default.
• W2995755001 cites W1851654707 @default.
• W2995755001 cites W1880261570 @default.
• W2995755001 cites W1889138213 @default.
• W2995755001 cites W1911378077 @default.
• W2995755001 cites W1919542101 @default.
• W2995755001 cites W1936785944 @default.
• W2995755001 cites W1963525353 @default.
• W2995755001 cites W1964724613 @default.
• W2995755001 cites W1964952275 @default.
• W2995755001 cites W1965406846 @default.
• W2995755001 cites W1965663600 @default.
• W2995755001 cites W1965776183 @default.
• W2995755001 cites W1967780293 @default.
• W2995755001 cites W1968945175 @default.
• W2995755001 cites W1971189295 @default.
• W2995755001 cites W1971344124 @default.
• W2995755001 cites W1972056287 @default.
• W2995755001 cites W1974841702 @default.
• W2995755001 cites W1975668138 @default.
• W2995755001 cites W1976019710 @default.
• W2995755001 cites W1977587126 @default.
• W2995755001 cites W1981739486 @default.
• W2995755001 cites W1982298072 @default.
• W2995755001 cites W1983960474 @default.
• W2995755001 cites W1984000281 @default.
• W2995755001 cites W1985268435 @default.
• W2995755001 cites W1986206654 @default.
• W2995755001 cites W1986323351 @default.
• W2995755001 cites W1987020327 @default.
• W2995755001 cites W1987298352 @default.
• W2995755001 cites W1987579856 @default.
• W2995755001 cites W1988132969 @default.
• W2995755001 cites W1989189858 @default.
• W2995755001 cites W1989270410 @default.
• W2995755001 cites W1989724420 @default.
• W2995755001 cites W1989986686 @default.
• W2995755001 cites W1990042350 @default.
• W2995755001 cites W1999635110 @default.
• W2995755001 cites W2001129585 @default.
• W2995755001 cites W2001131896 @default.
• W2995755001 cites W2002279230 @default.
• W2995755001 cites W2003797494 @default.
• W2995755001 cites W2005951413 @default.
• W2995755001 cites W2007335607 @default.
• W2995755001 cites W2007455229 @default.
• W2995755001 cites W2009045179 @default.
• W2995755001 cites W2010136266 @default.
• W2995755001 cites W2010185204 @default.
• W2995755001 cites W2010423339 @default.
• W2995755001 cites W2010722865 @default.
• W2995755001 cites W2011718183 @default.
• W2995755001 cites W2014156318 @default.
• W2995755001 cites W2015142672 @default.
• W2995755001 cites W2016744620 @default.
• W2995755001 cites W2018733207 @default.
• W2995755001 cites W2019401805 @default.
• W2995755001 cites W2020123224 @default.
• W2995755001 cites W2020320083 @default.
• W2995755001 cites W2021360821 @default.
• W2995755001 cites W2023302444 @default.
• W2995755001 cites W2024342829 @default.
• W2995755001 cites W2024621487 @default.
• W2995755001 cites W2026188485 @default.
• W2995755001 cites W2027658514 @default.
• W2995755001 cites W2027931582 @default.
• W2995755001 cites W2029087047 @default.
• W2995755001 cites W2029623796 @default.
• W2995755001 cites W2030310872 @default.
• W2995755001 cites W2030830933 @default.
• W2995755001 cites W2031163840 @default.
• W2995755001 cites W2032755153 @default.
• W2995755001 cites W2033033065 @default.
• W2995755001 cites W2034205729 @default.
• W2995755001 cites W2036268392 @default.
• W2995755001 cites W2037132137 @default.
• W2995755001 cites W2037304999 @default.
• W2995755001 cites W2037464856 @default.
• W2995755001 cites W2038050457 @default.
• W2995755001 cites W2038064315 @default.
• W2995755001 cites W2038120147 @default.
• W2995755001 cites W2038648355 @default.
• W2995755001 cites W2039051284 @default.
• W2995755001 cites W2039732263 @default.
• W2995755001 cites W2039767072 @default.
• W2995755001 cites W2040933173 @default.
• W2995755001 cites W2041241643 @default.

• next