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• W2995798678 abstract "Rationale Discovering and identifying new small-molecule inhibitors of monoamine oxidase B (MAO-B) could provide the potential to treat many neurodegenerative diseases. Methods We employed affinity ultrafiltration liquid chromatography/tandem mass spectrometry (AUF-LC/MSn) to identify and characterize small-molecule inhibitors of MAO-B from a 30% ethanolic extract of Acanthopanax senticosus root (ASR). In vitro tests were performed in stimulated BV2 microglia to evaluate the anti-inflammatory effects of the ASR preparation. An in vitro enzyme activity assay, measuring half-maximal inhibitory concentrations (IC50) against MAO-B, determined the inhibitory activity of the potential MAO-B ligands. Results ASR treatment significantly inhibited NO release (p <0.01) and attenuated tumor necrosis factor (TNF)-α expression in stimulated BV2 microglia. Nine compounds were isolated from the ASR preparation as potential MAO-B inhibitors, identified as quinic acid, chlorogenic acid, isofraxidin, dicaffeoylquinic acid, pinoresinol diglucoside, medioresinol 4’-O-β-D-glucopyranoside, eletutheroside E, syringaresinol O-β-D-glucoside, and trihydroxyoctadecenoic acid, based on their tandem mass spectra. Conclusions Our study provides critical data on compounds from ASR extracts which are suitable for the development of new MAO-B inhibitors as potential therapeutics for neurodegenerative diseases." @default.
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• W2995798678 date "2020-02-19" @default.
• W2995798678 modified "2023-10-14" @default.
• W2995798678 title "Chemical characterization of small‐molecule inhibitors of monoamine oxidase B synthesized from the <scp> <i>Acanthopanax senticosus</i> </scp> root with affinity ultrafiltration mass spectrometry" @default.
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• W2995798678 doi "https://doi.org/10.1002/rcm.8694" @default.
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