FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995802822> ?p ?o ?g. }

• W2995802822 endingPage "211" @default.
• W2995802822 startingPage "204" @default.
• W2995802822 abstract "The aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line antiretroviral therapy and risk of virological failure (VF) with or without drug resistance.We conducted an analysis of UK Collaborative HIV Cohort data linked to the UK HIV Drug Resistance Database. Inclusion criteria were viral sequence showing no resistance prior to initiation of first-line efavirenz + tenofovir disoproxil fumarate + emtricitabine and virological suppression within 6 months. Outcomes of VF (≥200 copies/mL) with or without drug resistance were assessed using a competing risks approach fitted jointly with a model for CD4 cell count recovery. Hazard ratios for each VF outcome were estimated for baseline CD4 cell count and viral load and characteristics of CD4 cell count response using latent variables on a standard normal scale.A total of 3640 people were included with 338 VF events; corresponding viral sequences were available in 134 with ≥1 resistance mutation in 36. VF with resistance was associated with lower baseline CD4 (0.30, 0.09-0.62), lower CD4 recovery (0.04, 0.00-0.17) and higher CD4 variability (4.40, 1.22-12.68). A different pattern of associations was observed for VF without resistance, but the strength of these results was less consistent across sensitivity analyses. Cumulative incidence of VF with resistance was estimated to be <2% at 3 years for baseline CD4 ≥350 cells/μL.Lower baseline CD4 cell count and suboptimal CD4 recovery are associated with VF with drug resistance. People with low CD4 cell count before ART or with suboptimal CD4 recovery on treatment should be a priority for regimens with high genetic barrier to resistance." @default.
• W2995802822 created "2019-12-26" @default.
• W2995802822 creator A5000379925 @default.
• W2995802822 creator A5001753109 @default.
• W2995802822 creator A5001932352 @default.
• W2995802822 creator A5001953752 @default.
• W2995802822 creator A5002102918 @default.
• W2995802822 creator A5002464688 @default.
• W2995802822 creator A5002493314 @default.
• W2995802822 creator A5002570101 @default.
• W2995802822 creator A5002838922 @default.
• W2995802822 creator A5004174170 @default.
• W2995802822 creator A5004443669 @default.
• W2995802822 creator A5004491232 @default.
• W2995802822 creator A5006458734 @default.
• W2995802822 creator A5006623516 @default.
• W2995802822 creator A5007462629 @default.
• W2995802822 creator A5008008069 @default.
• W2995802822 creator A5008173217 @default.
• W2995802822 creator A5008296751 @default.
• W2995802822 creator A5012051364 @default.
• W2995802822 creator A5012564817 @default.
• W2995802822 creator A5013078758 @default.
• W2995802822 creator A5013215998 @default.
• W2995802822 creator A5014109607 @default.
• W2995802822 creator A5014224122 @default.
• W2995802822 creator A5014497784 @default.
• W2995802822 creator A5015455617 @default.
• W2995802822 creator A5016093074 @default.
• W2995802822 creator A5016705465 @default.
• W2995802822 creator A5017146733 @default.
• W2995802822 creator A5017292612 @default.
• W2995802822 creator A5017405641 @default.
• W2995802822 creator A5017918526 @default.
• W2995802822 creator A5018226187 @default.
• W2995802822 creator A5019315196 @default.
• W2995802822 creator A5021886690 @default.
• W2995802822 creator A5021992166 @default.
• W2995802822 creator A5023098195 @default.
• W2995802822 creator A5024782736 @default.
• W2995802822 creator A5024895476 @default.
• W2995802822 creator A5026067896 @default.
• W2995802822 creator A5026739624 @default.
• W2995802822 creator A5027792801 @default.
• W2995802822 creator A5027846201 @default.
• W2995802822 creator A5027937855 @default.
• W2995802822 creator A5028172394 @default.
• W2995802822 creator A5029040151 @default.
• W2995802822 creator A5029741921 @default.
• W2995802822 creator A5029808671 @default.
• W2995802822 creator A5029861967 @default.
• W2995802822 creator A5029970471 @default.
• W2995802822 creator A5030775229 @default.
• W2995802822 creator A5031616182 @default.
• W2995802822 creator A5031723032 @default.
• W2995802822 creator A5032461496 @default.
• W2995802822 creator A5032903678 @default.
• W2995802822 creator A5033461095 @default.
• W2995802822 creator A5034140040 @default.
• W2995802822 creator A5034485858 @default.
• W2995802822 creator A5035923512 @default.
• W2995802822 creator A5038362714 @default.
• W2995802822 creator A5039721541 @default.
• W2995802822 creator A5040228620 @default.
• W2995802822 creator A5040604689 @default.
• W2995802822 creator A5041127164 @default.
• W2995802822 creator A5041574504 @default.
• W2995802822 creator A5041764334 @default.
• W2995802822 creator A5044377404 @default.
• W2995802822 creator A5045426449 @default.
• W2995802822 creator A5045655549 @default.
• W2995802822 creator A5045807116 @default.
• W2995802822 creator A5045843026 @default.
• W2995802822 creator A5046254202 @default.
• W2995802822 creator A5046972114 @default.
• W2995802822 creator A5047374087 @default.
• W2995802822 creator A5047490503 @default.
• W2995802822 creator A5048050447 @default.
• W2995802822 creator A5048657899 @default.
• W2995802822 creator A5048690257 @default.
• W2995802822 creator A5049513687 @default.
• W2995802822 creator A5050583650 @default.
• W2995802822 creator A5051573277 @default.
• W2995802822 creator A5051791661 @default.
• W2995802822 creator A5053100916 @default.
• W2995802822 creator A5054924055 @default.
• W2995802822 creator A5058253520 @default.
• W2995802822 creator A5060207711 @default.
• W2995802822 creator A5062146297 @default.
• W2995802822 creator A5063182513 @default.
• W2995802822 creator A5063541982 @default.
• W2995802822 creator A5065768749 @default.
• W2995802822 creator A5066346658 @default.
• W2995802822 creator A5066628797 @default.
• W2995802822 creator A5067000955 @default.
• W2995802822 creator A5067817297 @default.
• W2995802822 creator A5068239897 @default.
• W2995802822 creator A5071196544 @default.

• next