Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995808475> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2995808475 endingPage "724" @default.
- W2995808475 startingPage "719" @default.
- W2995808475 abstract "Outer membrane vesicles (OMVs) were isolated from an Acinetobacter strain deficient in lipopolysaccharide (LPS) due to a mutation in lpxD (IB010). Two immunizations with 10 µg of IB010 OMVs elicited total IgG, IgM, IgG1 and IgG2c titers similar to those observed after immunization with OMVs derived from the parental strain (ATCC 19606), and IB010 OMVs plus purified LPS. Immunization with IB010 OMVs resulted in significantly reduced post-infection spleen bacterial loads and serum IL-1β and IL-6 levels compared to control mice in a disseminated sepsis model. Mice immunized with 10 µg IB010 OMVs demonstrated significant, but partial, protection (75%) against infection, whereas mice immunized with ATCC 19606 OMVs or IB010 OMVs plus purified LPS were completely protected. Immunization of mice with 100 µg of IB010 OMVs completely protected mice from infection. This study demonstrates that LPS deficient A. baumannii produces OMVs, and that immunization with these OMVs elicits protective immunity against infection." @default.
- W2995808475 created "2019-12-26" @default.
- W2995808475 creator A5035389792 @default.
- W2995808475 creator A5076347067 @default.
- W2995808475 creator A5078163920 @default.
- W2995808475 creator A5087945181 @default.
- W2995808475 date "2020-01-01" @default.
- W2995808475 modified "2023-10-14" @default.
- W2995808475 title "A lipopolysaccharide-free outer membrane vesicle vaccine protects against Acinetobacter baumannii infection" @default.
- W2995808475 cites W1135522795 @default.
- W2995808475 cites W2063730198 @default.
- W2995808475 cites W2073960785 @default.
- W2995808475 cites W2074965142 @default.
- W2995808475 cites W2083206138 @default.
- W2995808475 cites W2083657436 @default.
- W2995808475 cites W2114165631 @default.
- W2995808475 cites W2138382635 @default.
- W2995808475 cites W2142140480 @default.
- W2995808475 cites W2415003003 @default.
- W2995808475 cites W2616940204 @default.
- W2995808475 cites W2806465105 @default.
- W2995808475 cites W2808764128 @default.
- W2995808475 cites W2904911553 @default.
- W2995808475 cites W2913159336 @default.
- W2995808475 cites W2939055544 @default.
- W2995808475 cites W2940507915 @default.
- W2995808475 cites W2951524316 @default.
- W2995808475 doi "https://doi.org/10.1016/j.vaccine.2019.11.043" @default.
- W2995808475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31843268" @default.
- W2995808475 hasPublicationYear "2020" @default.
- W2995808475 type Work @default.
- W2995808475 sameAs 2995808475 @default.
- W2995808475 citedByCount "32" @default.
- W2995808475 countsByYear W29958084752020 @default.
- W2995808475 countsByYear W29958084752021 @default.
- W2995808475 countsByYear W29958084752022 @default.
- W2995808475 countsByYear W29958084752023 @default.
- W2995808475 crossrefType "journal-article" @default.
- W2995808475 hasAuthorship W2995808475A5035389792 @default.
- W2995808475 hasAuthorship W2995808475A5076347067 @default.
- W2995808475 hasAuthorship W2995808475A5078163920 @default.
- W2995808475 hasAuthorship W2995808475A5087945181 @default.
- W2995808475 hasConcept C104317684 @default.
- W2995808475 hasConcept C146587185 @default.
- W2995808475 hasConcept C159047783 @default.
- W2995808475 hasConcept C203014093 @default.
- W2995808475 hasConcept C2776315533 @default.
- W2995808475 hasConcept C2777637488 @default.
- W2995808475 hasConcept C2778754761 @default.
- W2995808475 hasConcept C2779341262 @default.
- W2995808475 hasConcept C2780801004 @default.
- W2995808475 hasConcept C2780931953 @default.
- W2995808475 hasConcept C523546767 @default.
- W2995808475 hasConcept C54355233 @default.
- W2995808475 hasConcept C547475151 @default.
- W2995808475 hasConcept C55493867 @default.
- W2995808475 hasConcept C86803240 @default.
- W2995808475 hasConcept C8891405 @default.
- W2995808475 hasConcept C89423630 @default.
- W2995808475 hasConceptScore W2995808475C104317684 @default.
- W2995808475 hasConceptScore W2995808475C146587185 @default.
- W2995808475 hasConceptScore W2995808475C159047783 @default.
- W2995808475 hasConceptScore W2995808475C203014093 @default.
- W2995808475 hasConceptScore W2995808475C2776315533 @default.
- W2995808475 hasConceptScore W2995808475C2777637488 @default.
- W2995808475 hasConceptScore W2995808475C2778754761 @default.
- W2995808475 hasConceptScore W2995808475C2779341262 @default.
- W2995808475 hasConceptScore W2995808475C2780801004 @default.
- W2995808475 hasConceptScore W2995808475C2780931953 @default.
- W2995808475 hasConceptScore W2995808475C523546767 @default.
- W2995808475 hasConceptScore W2995808475C54355233 @default.
- W2995808475 hasConceptScore W2995808475C547475151 @default.
- W2995808475 hasConceptScore W2995808475C55493867 @default.
- W2995808475 hasConceptScore W2995808475C86803240 @default.
- W2995808475 hasConceptScore W2995808475C8891405 @default.
- W2995808475 hasConceptScore W2995808475C89423630 @default.
- W2995808475 hasIssue "4" @default.
- W2995808475 hasLocation W29958084751 @default.
- W2995808475 hasOpenAccess W2995808475 @default.
- W2995808475 hasPrimaryLocation W29958084751 @default.
- W2995808475 hasRelatedWork W136522893 @default.
- W2995808475 hasRelatedWork W1982584042 @default.
- W2995808475 hasRelatedWork W1989619883 @default.
- W2995808475 hasRelatedWork W2005271347 @default.
- W2995808475 hasRelatedWork W2027539993 @default.
- W2995808475 hasRelatedWork W2036495427 @default.
- W2995808475 hasRelatedWork W2094317060 @default.
- W2995808475 hasRelatedWork W2113164820 @default.
- W2995808475 hasRelatedWork W2567370154 @default.
- W2995808475 hasRelatedWork W4237163253 @default.
- W2995808475 hasVolume "38" @default.
- W2995808475 isParatext "false" @default.
- W2995808475 isRetracted "false" @default.
- W2995808475 magId "2995808475" @default.
- W2995808475 workType "article" @default.