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• W299581075 abstract "Research Article1 July 1991free access Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA. T. Dandekar T. Dandekar European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author R. Stripecke R. Stripecke European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author N.K. Gray N.K. Gray European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author B. Goossen B. Goossen European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author A. Constable A. Constable European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author H.E. Johansson H.E. Johansson European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author M.W. Hentze M.W. Hentze European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author T. Dandekar T. Dandekar European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author R. Stripecke R. Stripecke European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author N.K. Gray N.K. Gray European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author B. Goossen B. Goossen European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author A. Constable A. Constable European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author H.E. Johansson H.E. Johansson European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author M.W. Hentze M.W. Hentze European Molecular Biology Laboratory, Heidelberg FRG. Search for more papers by this author Author Information T. Dandekar1, R. Stripecke1, N.K. Gray1, B. Goossen1, A. Constable1, H.E. Johansson1 and M.W. Hentze1 1European Molecular Biology Laboratory, Heidelberg FRG. The EMBO Journal (1991)10:1903-1909https://doi.org/10.1002/j.1460-2075.1991.tb07716.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Iron-responsive elements (IREs) are regulatory RNA elements which are characterized by a phylogenetically defined sequence-structure motif. Their biological function is to provide a specific binding site for the IRE-binding protein (IRE-BP). Iron starvation of cells induces high affinity binding of the cytoplasmic IRE-BP to an IRE which has at least two different known biological consequences, repression of ferritin mRNA translation and stabilization of the transferrin receptor transcript. We report the identification of a novel, evolutionarily conserved IRE motif in the 5′ UTR of murine and human erythroid-specific delta-aminolevulinic acid synthase (eALAS) mRNA which encodes the first, and possibly rate limiting, enzyme of the heme biosynthetic pathway. We demonstrate the function of the eALAS IRE as a specific binding site for the IRE-BP by gel retardation analyses and by in vitro translation experiments. In addition, we show that the 5′ UTR of eALAS mRNA is sufficient to mediate iron-dependent translational regulation in vivo. These findings strongly suggest involvement of the IRE-IRE-BP system in the control of heme biosynthesis during erythroid differentiation. Previous ArticleNext Article Volume 10Issue 71 July 1991In this issue RelatedDetailsLoading ..." @default.
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• W299581075 title "Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA." @default.
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