Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995864275> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2995864275 abstract "Abstract Drug-metabolizing cytochrome P450 (CYP) enzymes are especially important in wild animals as they are directly exposed to environmental pollutants and bioactive molecules of plants. Our main goal was to monitor the activity of certain CYP enzymes in wild boar compared to domestic swine, and to assess various modulatory factors of xenobiotic biotransformation in wild boar. Liver and intestinal mucosa (duodenum, jejunum, ileum, caecum) samples were collected from 49 hunted free-range wild boars and 15 wild boar fetuses; domestic pig samples (n = 40) were gained from a slaughter house. Specific activity of CYP1A2, CYP2C9, and CYP3A4 enzymes was assessed by luminometric assays. The activity of hepatic CYP1A2 and CYP3A4 enzymes was significantly higher in wild boars than in domestic pigs, while CYP2C9-mediated hepatic metabolism was significantly less intense in wild boars than in pigs. Certain modulatory factors (sex, sexual maturation, and season) were also confirmed in wild boars. The activity of all investigated intestinal CYP enzymes remained under detection level in each gut section in both species. Hepatic CYP2C9 and CYP3A4 enzymes were measurable in wild boar fetuses, but their activity was remarkably lower than in adults. The described interspecies differences might be explained with the altered exposure of wild and domesticated animals to specific CYP modulators. As CYP enzymes in wild boars can be highly influenced by environmental pollutants, following further studies, they may serve as ecotoxicological markers of agricultural or industrial toxicants. Investigating CYP-related drug metabolism in wildlife species can clarify some toxicokinetic interactions, thus having huge importance in the production of safe game meat." @default.
- W2995864275 created "2019-12-26" @default.
- W2995864275 creator A5000824682 @default.
- W2995864275 creator A5003945909 @default.
- W2995864275 creator A5012798154 @default.
- W2995864275 creator A5033275024 @default.
- W2995864275 creator A5034576331 @default.
- W2995864275 creator A5045610195 @default.
- W2995864275 date "2019-12-19" @default.
- W2995864275 modified "2023-10-17" @default.
- W2995864275 title "Investigations on hepatic and intestinal drug-metabolizing cytochrome P450 enzymes in wild boar compared to domestic swine" @default.
- W2995864275 cites W1210514451 @default.
- W2995864275 cites W1974256331 @default.
- W2995864275 cites W1984574841 @default.
- W2995864275 cites W1994139315 @default.
- W2995864275 cites W2001391006 @default.
- W2995864275 cites W2002124729 @default.
- W2995864275 cites W2007109043 @default.
- W2995864275 cites W2017577604 @default.
- W2995864275 cites W2022435477 @default.
- W2995864275 cites W2051863978 @default.
- W2995864275 cites W2064883756 @default.
- W2995864275 cites W2071693879 @default.
- W2995864275 cites W2071803670 @default.
- W2995864275 cites W2071852961 @default.
- W2995864275 cites W2074605027 @default.
- W2995864275 cites W2075468194 @default.
- W2995864275 cites W2078858903 @default.
- W2995864275 cites W2083135851 @default.
- W2995864275 cites W2107567029 @default.
- W2995864275 cites W2108009673 @default.
- W2995864275 cites W2121820971 @default.
- W2995864275 cites W2133279477 @default.
- W2995864275 cites W2135661105 @default.
- W2995864275 cites W2137738261 @default.
- W2995864275 cites W2142642034 @default.
- W2995864275 cites W2151040468 @default.
- W2995864275 cites W2498645524 @default.
- W2995864275 cites W2567359080 @default.
- W2995864275 cites W2586663109 @default.
- W2995864275 cites W2740235509 @default.
- W2995864275 cites W2797323304 @default.
- W2995864275 doi "https://doi.org/10.1007/s10344-019-1345-8" @default.
- W2995864275 hasPublicationYear "2019" @default.
- W2995864275 type Work @default.
- W2995864275 sameAs 2995864275 @default.
- W2995864275 citedByCount "3" @default.
- W2995864275 countsByYear W29958642752020 @default.
- W2995864275 countsByYear W29958642752021 @default.
- W2995864275 crossrefType "journal-article" @default.
- W2995864275 hasAuthorship W2995864275A5000824682 @default.
- W2995864275 hasAuthorship W2995864275A5003945909 @default.
- W2995864275 hasAuthorship W2995864275A5012798154 @default.
- W2995864275 hasAuthorship W2995864275A5033275024 @default.
- W2995864275 hasAuthorship W2995864275A5034576331 @default.
- W2995864275 hasAuthorship W2995864275A5045610195 @default.
- W2995864275 hasBestOaLocation W29958642751 @default.
- W2995864275 hasConcept C109650736 @default.
- W2995864275 hasConcept C115448650 @default.
- W2995864275 hasConcept C181199279 @default.
- W2995864275 hasConcept C18903297 @default.
- W2995864275 hasConcept C205649164 @default.
- W2995864275 hasConcept C2776222705 @default.
- W2995864275 hasConcept C2778134537 @default.
- W2995864275 hasConcept C526171541 @default.
- W2995864275 hasConcept C55493867 @default.
- W2995864275 hasConcept C86745063 @default.
- W2995864275 hasConcept C86803240 @default.
- W2995864275 hasConcept C89311334 @default.
- W2995864275 hasConcept C97137747 @default.
- W2995864275 hasConceptScore W2995864275C109650736 @default.
- W2995864275 hasConceptScore W2995864275C115448650 @default.
- W2995864275 hasConceptScore W2995864275C181199279 @default.
- W2995864275 hasConceptScore W2995864275C18903297 @default.
- W2995864275 hasConceptScore W2995864275C205649164 @default.
- W2995864275 hasConceptScore W2995864275C2776222705 @default.
- W2995864275 hasConceptScore W2995864275C2778134537 @default.
- W2995864275 hasConceptScore W2995864275C526171541 @default.
- W2995864275 hasConceptScore W2995864275C55493867 @default.
- W2995864275 hasConceptScore W2995864275C86745063 @default.
- W2995864275 hasConceptScore W2995864275C86803240 @default.
- W2995864275 hasConceptScore W2995864275C89311334 @default.
- W2995864275 hasConceptScore W2995864275C97137747 @default.
- W2995864275 hasLocation W29958642751 @default.
- W2995864275 hasOpenAccess W2995864275 @default.
- W2995864275 hasPrimaryLocation W29958642751 @default.
- W2995864275 hasRelatedWork W14345246 @default.
- W2995864275 hasRelatedWork W24195081 @default.
- W2995864275 hasRelatedWork W25443596 @default.
- W2995864275 hasRelatedWork W25805112 @default.
- W2995864275 hasRelatedWork W2606579 @default.
- W2995864275 hasRelatedWork W28231665 @default.
- W2995864275 hasRelatedWork W30860501 @default.
- W2995864275 hasRelatedWork W37725492 @default.
- W2995864275 hasRelatedWork W38847907 @default.
- W2995864275 hasRelatedWork W7219427 @default.
- W2995864275 isParatext "false" @default.
- W2995864275 isRetracted "false" @default.
- W2995864275 magId "2995864275" @default.
- W2995864275 workType "article" @default.