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• W2995865170 abstract "Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition. The degree to which the brain development in ASD deviates from typical brain development, and how this deviation relates to observed behavioral outcomes at the individual level are not well-studied. We hypothesize that the degree of deviation from typical brain development of an individual with ASD would relate to observed symptom severity.The developmental changes in anatomical (cortical thickness, surface area, and volume) and diffusion metrics (fractional anisotropy and apparent diffusion coefficient) were compared between a sample of ASD (n = 247) and typically developing children (TDC) (n = 220) aged 6-25. Machine learning was used to predict age (brain age) from these metrics in the TDC sample, to define a normative model of brain development. This model was then used to compute brain age in the ASD sample. The difference between chronological age and brain age was considered a developmental deviation index (DDI), which was then correlated with ASD symptom severity.Machine learning model trained on all five metrics accurately predicted age in the TDC (r = 0.88) and the ASD (r = 0.85) samples, with dominant contributions to the model from the diffusion metrics. Within the ASD group, the DDI derived from fractional anisotropy was correlated with ASD symptom severity (r = - 0.2), such that individuals with the most advanced brain age showing the lowest severity, and individuals with the most delayed brain age showing the highest severity.This work investigated only linear relationships between five specific brain metrics and only one measure of ASD symptom severity in a limited age range. Reported effect sizes are moderate. Further work is needed to investigate developmental differences in other age ranges, other aspects of behavior, other neurobiological measures, and in an independent sample before results can be clinically applicable.Findings demonstrate that the degree of deviation from typical brain development relates to ASD symptom severity, partially accounting for the observed heterogeneity in ASD. Our approach enables characterization of each individual with reference to normative brain development and identification of distinct developmental subtypes, facilitating a better understanding of developmental heterogeneity in ASD." @default.
• W2995865170 created "2019-12-26" @default.
• W2995865170 creator A5025453249 @default.
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• W2995865170 creator A5083518354 @default.
• W2995865170 creator A5086117355 @default.
• W2995865170 date "2019-12-01" @default.
• W2995865170 modified "2023-10-18" @default.
• W2995865170 title "Deviation from normative brain development is associated with symptom severity in autism spectrum disorder" @default.
• W2995865170 cites W1496968292 @default.
• W2995865170 cites W1579305661 @default.
• W2995865170 cites W1586484346 @default.
• W2995865170 cites W1711408934 @default.
• W2995865170 cites W1848922716 @default.
• W2995865170 cites W1918697652 @default.
• W2995865170 cites W1964191921 @default.
• W2995865170 cites W1964357740 @default.
• W2995865170 cites W1965364605 @default.
• W2995865170 cites W1965443741 @default.
• W2995865170 cites W1970848271 @default.
• W2995865170 cites W1972817961 @default.
• W2995865170 cites W1974114918 @default.
• W2995865170 cites W1984331840 @default.
• W2995865170 cites W1990134753 @default.
• W2995865170 cites W2000619876 @default.
• W2995865170 cites W2001612051 @default.
• W2995865170 cites W2004046545 @default.
• W2995865170 cites W2005387911 @default.
• W2995865170 cites W2009872283 @default.
• W2995865170 cites W2010651179 @default.
• W2995865170 cites W2011388541 @default.
• W2995865170 cites W2011409753 @default.
• W2995865170 cites W2021915551 @default.
• W2995865170 cites W2025551837 @default.
• W2995865170 cites W2026125217 @default.
• W2995865170 cites W2026812901 @default.
• W2995865170 cites W2037759571 @default.
• W2995865170 cites W2039929057 @default.
• W2995865170 cites W2041476874 @default.
• W2995865170 cites W2041527603 @default.
• W2995865170 cites W2042226031 @default.
• W2995865170 cites W2042474217 @default.
• W2995865170 cites W2047852850 @default.
• W2995865170 cites W2053258586 @default.
• W2995865170 cites W2054216238 @default.
• W2995865170 cites W2054875016 @default.
• W2995865170 cites W2058676477 @default.
• W2995865170 cites W2062464666 @default.
• W2995865170 cites W2067774627 @default.
• W2995865170 cites W2071569604 @default.
• W2995865170 cites W2090153386 @default.
• W2995865170 cites W2092245015 @default.
• W2995865170 cites W2094982358 @default.
• W2995865170 cites W2101135654 @default.
• W2995865170 cites W2101288418 @default.
• W2995865170 cites W2107854082 @default.
• W2995865170 cites W2109135855 @default.
• W2995865170 cites W2109181684 @default.
• W2995865170 cites W2113127248 @default.
• W2995865170 cites W2113136223 @default.
• W2995865170 cites W2115716215 @default.
• W2995865170 cites W2117340355 @default.
• W2995865170 cites W2117987496 @default.
• W2995865170 cites W2118160932 @default.
• W2995865170 cites W2118427991 @default.
• W2995865170 cites W2118607380 @default.
• W2995865170 cites W2120646369 @default.
• W2995865170 cites W2126819661 @default.
• W2995865170 cites W2129516277 @default.
• W2995865170 cites W2133015692 @default.
• W2995865170 cites W2136891170 @default.
• W2995865170 cites W2138153039 @default.
• W2995865170 cites W2144446993 @default.
• W2995865170 cites W2150286266 @default.
• W2995865170 cites W2152176777 @default.
• W2995865170 cites W2152292563 @default.
• W2995865170 cites W2158063953 @default.
• W2995865170 cites W2159500608 @default.
• W2995865170 cites W2163166919 @default.
• W2995865170 cites W2163397436 @default.
• W2995865170 cites W2164036505 @default.
• W2995865170 cites W2166109328 @default.
• W2995865170 cites W2167579130 @default.
• W2995865170 cites W2176762524 @default.
• W2995865170 cites W2178472169 @default.
• W2995865170 cites W2192471164 @default.
• W2995865170 cites W2229782077 @default.
• W2995865170 cites W2318996262 @default.
• W2995865170 cites W2467263299 @default.
• W2995865170 cites W2516290620 @default.
• W2995865170 cites W2517916735 @default.
• W2995865170 cites W2520744072 @default.
• W2995865170 cites W2565992085 @default.
• W2995865170 cites W2579617530 @default.
• W2995865170 cites W2588003167 @default.
• W2995865170 cites W2590910803 @default.
• W2995865170 cites W2593448428 @default.

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