FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995874227> ?p ?o ?g. }

• W2995874227 endingPage "114" @default.
• W2995874227 startingPage "102" @default.
• W2995874227 abstract "There are no effective therapeutic drugs for cerebral aneurysms, partly because the pathogenesis remains unresolved. Chronic inflammation of the cerebral arterial wall plays an important role in aneurysm formation, but it is not clear what triggers the inflammation. The authors have observed that vascular endothelial P2X4 purinoceptor is involved in flow-sensitive mechanisms that regulate vascular remodeling. They have thus hypothesized that shear stress-associated hemodynamic stress on the endothelium causes the inflammatory process in the cerebral aneurysm development.To test their hypothesis, the authors examined the role of P2X4 in cerebral aneurysm development by using P2X4-/- mice and rats that were treated with a P2X4 inhibitor, paroxetine, and subjected to aneurysm-inducing surgery. Cerebral aneurysms were induced by unilateral carotid artery ligation and renovascular hypertension.The frequency of aneurysm induction evaluated by light microscopy was significantly lower in the P2X4-/- mice (p = 0.0488) and in the paroxetine-treated male (p = 0.0253) and female (p = 0.0204) rats compared to control mice and rats, respectively. In addition, application of paroxetine from 2 weeks after surgery led to a significant reduction in aneurysm size in the rats euthanized 3 weeks after aneurysm-inducing surgery (p = 0.0145), indicating that paroxetine suppressed enlargement of formed aneurysms. The mRNA and protein expression levels of known inflammatory contributors to aneurysm formation (monocyte chemoattractant protein-1 [MCP-1], interleukin-1β [IL-1β], tumor necrosis factor-α [TNFα], inducible nitric oxide synthase [iNOS], and cyclooxygenase-2 [COX-2]) were all significantly elevated in the rats that underwent the aneurysm-inducing surgery compared to the nonsurgical group, and the values in the surgical group were all significantly decreased by paroxetine administration according to quantitative polymerase chain reaction techniques and Western blotting. Although immunolabeling densities for COX-2, iNOS, and MCP-1 were not readily observed in the nonsurgical mouse groups, such densities were clearly seen in the arterial wall of P2X4+/+ mice after aneurysm-inducing surgery. In contrast, in the P2X4-/- mice after the surgery, immunolabeling of COX-2 and iNOS was not observed in the arterial wall, whereas that of MCP-1 was readily observed in the adventitia, but not the intima.These data suggest that P2X4 is required for the inflammation that contributes to both cerebral aneurysm formation and growth. Enhanced shear stress-associated hemodynamic stress on the vascular endothelium may trigger cerebral aneurysm development. Paroxetine may have potential for the clinical treatment of cerebral aneurysms, given that this agent exhibits efficacy as a clinical antidepressant." @default.
• W2995874227 created "2019-12-26" @default.
• W2995874227 creator A5000105049 @default.
• W2995874227 creator A5017003182 @default.
• W2995874227 creator A5020046509 @default.
• W2995874227 creator A5020990704 @default.
• W2995874227 creator A5023347677 @default.
• W2995874227 creator A5048073579 @default.
• W2995874227 creator A5049525309 @default.
• W2995874227 creator A5049772836 @default.
• W2995874227 creator A5068628771 @default.
• W2995874227 creator A5072002120 @default.
• W2995874227 creator A5074360690 @default.
• W2995874227 creator A5082936913 @default.
• W2995874227 date "2021-01-01" @default.
• W2995874227 modified "2023-10-11" @default.
• W2995874227 title "Disruption of P2X4 purinoceptor and suppression of the inflammation associated with cerebral aneurysm formation" @default.
• W2995874227 cites W1502430973 @default.
• W2995874227 cites W1562015762 @default.
• W2995874227 cites W1668498597 @default.
• W2995874227 cites W1964678173 @default.
• W2995874227 cites W1968512491 @default.
• W2995874227 cites W1975020669 @default.
• W2995874227 cites W1982028040 @default.
• W2995874227 cites W1992375374 @default.
• W2995874227 cites W1996049598 @default.
• W2995874227 cites W2025921854 @default.
• W2995874227 cites W2025998654 @default.
• W2995874227 cites W2039268722 @default.
• W2995874227 cites W2047484424 @default.
• W2995874227 cites W2059487790 @default.
• W2995874227 cites W2063152480 @default.
• W2995874227 cites W2064173520 @default.
• W2995874227 cites W2065408991 @default.
• W2995874227 cites W2066531718 @default.
• W2995874227 cites W2082823921 @default.
• W2995874227 cites W2083507739 @default.
• W2995874227 cites W2088088326 @default.
• W2995874227 cites W2109284659 @default.
• W2995874227 cites W2112200720 @default.
• W2995874227 cites W2119792097 @default.
• W2995874227 cites W2119887244 @default.
• W2995874227 cites W2148640061 @default.
• W2995874227 cites W2165969534 @default.
• W2995874227 cites W2167702627 @default.
• W2995874227 cites W2416908295 @default.
• W2995874227 cites W2547066587 @default.
• W2995874227 cites W2567891420 @default.
• W2995874227 cites W2587367335 @default.
• W2995874227 cites W2614066293 @default.
• W2995874227 cites W2724183530 @default.
• W2995874227 cites W2768623326 @default.
• W2995874227 cites W2796299018 @default.
• W2995874227 cites W2800975989 @default.
• W2995874227 cites W2936293112 @default.
• W2995874227 doi "https://doi.org/10.3171/2019.9.jns19270" @default.
• W2995874227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31860812" @default.
• W2995874227 hasPublicationYear "2021" @default.
• W2995874227 type Work @default.
• W2995874227 sameAs 2995874227 @default.
• W2995874227 citedByCount "4" @default.
• W2995874227 countsByYear W29958742272023 @default.
• W2995874227 crossrefType "journal-article" @default.
• W2995874227 hasAuthorship W2995874227A5000105049 @default.
• W2995874227 hasAuthorship W2995874227A5017003182 @default.
• W2995874227 hasAuthorship W2995874227A5020046509 @default.
• W2995874227 hasAuthorship W2995874227A5020990704 @default.
• W2995874227 hasAuthorship W2995874227A5023347677 @default.
• W2995874227 hasAuthorship W2995874227A5048073579 @default.
• W2995874227 hasAuthorship W2995874227A5049525309 @default.
• W2995874227 hasAuthorship W2995874227A5049772836 @default.
• W2995874227 hasAuthorship W2995874227A5068628771 @default.
• W2995874227 hasAuthorship W2995874227A5072002120 @default.
• W2995874227 hasAuthorship W2995874227A5074360690 @default.
• W2995874227 hasAuthorship W2995874227A5082936913 @default.
• W2995874227 hasBestOaLocation W29958742271 @default.
• W2995874227 hasConcept C126322002 @default.
• W2995874227 hasConcept C134018914 @default.
• W2995874227 hasConcept C141071460 @default.
• W2995874227 hasConcept C164705383 @default.
• W2995874227 hasConcept C171614378 @default.
• W2995874227 hasConcept C17991360 @default.
• W2995874227 hasConcept C2776098176 @default.
• W2995874227 hasConcept C2776914184 @default.
• W2995874227 hasConcept C2776992346 @default.
• W2995874227 hasConcept C2777622882 @default.
• W2995874227 hasConcept C2780942790 @default.
• W2995874227 hasConcept C42219234 @default.
• W2995874227 hasConcept C519581460 @default.
• W2995874227 hasConcept C71924100 @default.
• W2995874227 hasConceptScore W2995874227C126322002 @default.
• W2995874227 hasConceptScore W2995874227C134018914 @default.
• W2995874227 hasConceptScore W2995874227C141071460 @default.
• W2995874227 hasConceptScore W2995874227C164705383 @default.
• W2995874227 hasConceptScore W2995874227C171614378 @default.
• W2995874227 hasConceptScore W2995874227C17991360 @default.
• W2995874227 hasConceptScore W2995874227C2776098176 @default.
• W2995874227 hasConceptScore W2995874227C2776914184 @default.

• next