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- W2995883585 abstract "Summary Microtubules and F-actin have long been recognized as key regulators of dendritic morphology. Nevertheless, precisely ascertaining their distinct influences on dendritic trees have been hampered until now by the lack of direct, arbor-wide cytoskeletal quantification. We pair live confocal imaging of fluorescently labeled dendritic arborization (da) neurons in Drosophila larvae with complete multi-signal neural tracing to separately measure microtubules and F-actin. We demonstrate that dendritic arbor length is highly interrelated with local microtubule quantity, whereas local F-actin enrichment is associated with dendritic branching. Computational simulation of arbor structure solely constrained by experimentally observed subcellular distributions of these cytoskeletal components generated synthetic morphological and molecular patterns statistically equivalent to those of real da neurons, corroborating the efficacy of local microtubule and F-actin in describing dendritic architecture. The analysis and modeling outcomes hold true for the simplest (Class I), most complex (Class IV), and genetically altered (Formin3 overexpression) da neuron types. SUPPORT: NIH R01 NS39600 and NS086082 and BICCN U01 MH114829." @default.
- W2995883585 created "2019-12-26" @default.
- W2995883585 creator A5020506355 @default.
- W2995883585 creator A5023097404 @default.
- W2995883585 creator A5079684009 @default.
- W2995883585 creator A5087672831 @default.
- W2995883585 date "2019-12-22" @default.
- W2995883585 modified "2023-09-27" @default.
- W2995883585 title "Distinct relations of microtubules and actin filaments with dendritic architecture" @default.
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- W2995883585 doi "https://doi.org/10.1101/2019.12.22.885004" @default.