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- W2995890673 abstract "Among antibody-based cancer therapies, bispecific antibodies (biAbs) have gained momentum in preclinical and clinical investigations following the regulatory approvals of the trailblazing T-cell engaging biAb (T-biAb) blinatumomab. Discussed herein are recent strategies that aim at boosting the potency and mitigating the toxicity of T-biAbs, broadening their therapeutic utility from hematologic to solid malignancies, and generating T-biAbs in situ. In cancer immunotherapy, T-biAbs are facing fierce competition with chimeric antigen receptor T cells (CAR-Ts), a battle for clinical and commercial viability that will be closely watched. However, innovative combinations of T-biAbs and CAR-Ts have also transpired. NK-cell engaging biAbs (NK-biAbs) are reemerging as an alternative that addresses liabilities of T-biAbs. Beyond NK-biAbs, other biAbs designed to recruit cellular and molecular components of the innate immune system will be covered in this reflection on new tools, technologies, and targets." @default.
- W2995890673 created "2019-12-26" @default.
- W2995890673 creator A5065812703 @default.
- W2995890673 date "2020-10-01" @default.
- W2995890673 modified "2023-09-26" @default.
- W2995890673 title "Bispecific antibodies in cancer immunotherapy" @default.
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- W2995890673 doi "https://doi.org/10.1016/j.copbio.2019.11.020" @default.
- W2995890673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7292752" @default.
- W2995890673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31841859" @default.
- W2995890673 hasPublicationYear "2020" @default.
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