FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2995902683> ?p ?o ?g. }

• W2995902683 abstract "Abstract Purpose To evaluate a novel 5‐ring multifocal electroretinogram (mfERG) stimulus as a screening test for detecting hydroxychloroquine (HCQ) retinopathy. Study Design A stratified case‐control study conducted in accordance to the Standards for Reporting of Diagnostic Accuracy Studies (STARD). Methods Consecutive patients referred to the University of Ottawa for HCQ retinopathy screening from July 2018 to September 2018 underwent testing using a novel 5‐ring mfERG stimulus and the standard 61‐hexagon mfERG stimulus. Patients with amblyopia, high myopia or hyperopia, coexisting retinal disease, and prior retinal surgery were excluded. mfERG parameters were compared between protocols and against cumulative dose (CD), dose by real body weight (RBW), and duration of HCQ therapy. Ring amplitudes (R1‐R5) and ring ratios (R1‐R4/R5) were collected for each stimulus protocol. mfERG data was collected from an additional group of controls with no previous exposure to HCQ. Stata 15.1 software was used to perform the regression analyses, and to compute Spearman correlation coefficients between variables. Results 24 eyes (10 patients, 2 controls) were included in the final analysis. The novel R2 and R3 P1 amplitudes and R2/R5 were moderately correlated with the respective R2 (r = 0.434, p = 0.034) and R3 (r = 0.429, p = 0.036) P1 amplitudes and R2/R5 (r = 0.422, p = 0.040) of the 61‐hexagon stimulus. The novel R2 P1 amplitude was highly correlated with CD (r = −0.687, p < 0.001), treatment duration (r = −0.687, p < 0.001), and dose by RBW (r = −0.763, p < 0.001). Similarly, novel R2/R5 was highly correlated with CD (r = −0.743, p < 0.001), treatment duration (r = −0.743, p < 0.001), and dose by RBW (r = −0.567, p = 0.004). The correlations between the 61‐hexagon stimulus R2/R5 and HCQ risk factors also reached significance but were not as robust. Linear regression analysis showed that CD may account for almost half of the variance in the novel R2/R5. (r2 = 0.486, R2/R5 = 9.68063 + cumulative dose ‐0.00286) Conclusions The 2016 AAO guidelines focused primarily on the use of subjective functional testing and objective structural testing and relegated mfERG based on a lack of accessibility. This pilot study describes a new 5‐ring mfERG protocol specific for HCQ retinopathy screening and suggests equivalence to the 61‐hexagon protocol at characterizing parafoveal function. This novel 5‐ring stimulus has a significantly shorter acquisition period and the ring design may be more sensitive to HCQ induced electrophysiologic change in the parafoveal region. R2 P1 amplitude and R2/R5 ring ratios acquired using this novel mfERG stimulus are strongly correlated to treatment duration and HCQ dosing. Additional prospective cohort studies are needed to validate this novel stimulus which may decrease the resource burden associated with objective functional testing." @default.
• W2995902683 created "2019-12-26" @default.
• W2995902683 creator A5017476164 @default.
• W2995902683 creator A5036026336 @default.
• W2995902683 creator A5054157463 @default.
• W2995902683 creator A5077939074 @default.
• W2995902683 creator A5085123690 @default.
• W2995902683 creator A5088266722 @default.
• W2995902683 date "2019-12-01" @default.
• W2995902683 modified "2023-10-17" @default.
• W2995902683 title "Detecting Hydroxychloroquine Retinal Toxicity using a Novel Multifocal Electroretinography Stimulus" @default.
• W2995902683 doi "https://doi.org/10.1111/j.1755-3768.2019.5370" @default.
• W2995902683 hasPublicationYear "2019" @default.
• W2995902683 type Work @default.
• W2995902683 sameAs 2995902683 @default.
• W2995902683 citedByCount "1" @default.
• W2995902683 countsByYear W29959026832021 @default.
• W2995902683 crossrefType "journal-article" @default.
• W2995902683 hasAuthorship W2995902683A5017476164 @default.
• W2995902683 hasAuthorship W2995902683A5036026336 @default.
• W2995902683 hasAuthorship W2995902683A5054157463 @default.
• W2995902683 hasAuthorship W2995902683A5077939074 @default.
• W2995902683 hasAuthorship W2995902683A5085123690 @default.
• W2995902683 hasAuthorship W2995902683A5088266722 @default.
• W2995902683 hasBestOaLocation W29959026831 @default.
• W2995902683 hasConcept C118487528 @default.
• W2995902683 hasConcept C126322002 @default.
• W2995902683 hasConcept C134018914 @default.
• W2995902683 hasConcept C15744967 @default.
• W2995902683 hasConcept C2778313320 @default.
• W2995902683 hasConcept C2779113765 @default.
• W2995902683 hasConcept C2779123688 @default.
• W2995902683 hasConcept C2779134260 @default.
• W2995902683 hasConcept C2779918689 @default.
• W2995902683 hasConcept C2780827179 @default.
• W2995902683 hasConcept C3008058167 @default.
• W2995902683 hasConcept C524204448 @default.
• W2995902683 hasConcept C542102704 @default.
• W2995902683 hasConcept C555293320 @default.
• W2995902683 hasConcept C71924100 @default.
• W2995902683 hasConceptScore W2995902683C118487528 @default.
• W2995902683 hasConceptScore W2995902683C126322002 @default.
• W2995902683 hasConceptScore W2995902683C134018914 @default.
• W2995902683 hasConceptScore W2995902683C15744967 @default.
• W2995902683 hasConceptScore W2995902683C2778313320 @default.
• W2995902683 hasConceptScore W2995902683C2779113765 @default.
• W2995902683 hasConceptScore W2995902683C2779123688 @default.
• W2995902683 hasConceptScore W2995902683C2779134260 @default.
• W2995902683 hasConceptScore W2995902683C2779918689 @default.
• W2995902683 hasConceptScore W2995902683C2780827179 @default.
• W2995902683 hasConceptScore W2995902683C3008058167 @default.
• W2995902683 hasConceptScore W2995902683C524204448 @default.
• W2995902683 hasConceptScore W2995902683C542102704 @default.
• W2995902683 hasConceptScore W2995902683C555293320 @default.
• W2995902683 hasConceptScore W2995902683C71924100 @default.
• W2995902683 hasIssue "S263" @default.
• W2995902683 hasLocation W29959026831 @default.
• W2995902683 hasOpenAccess W2995902683 @default.
• W2995902683 hasPrimaryLocation W29959026831 @default.
• W2995902683 hasRelatedWork W1991960614 @default.
• W2995902683 hasRelatedWork W2359651333 @default.
• W2995902683 hasRelatedWork W2411987028 @default.
• W2995902683 hasRelatedWork W2466769549 @default.
• W2995902683 hasRelatedWork W2953042574 @default.
• W2995902683 hasRelatedWork W3027791452 @default.
• W2995902683 hasRelatedWork W3110506613 @default.
• W2995902683 hasRelatedWork W3149354770 @default.
• W2995902683 hasRelatedWork W3166698833 @default.
• W2995902683 hasRelatedWork W4377564725 @default.
• W2995902683 hasVolume "97" @default.
• W2995902683 isParatext "false" @default.
• W2995902683 isRetracted "false" @default.
• W2995902683 magId "2995902683" @default.
• W2995902683 workType "article" @default.