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- W2995903145 abstract "Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such protection is mediated, in large part, by two main B cell memory ‘walls’ — namely, long-lived plasma cells and memory B cells. The cellular and molecular processes that drive the production of long-lived plasma cells and memory B cells are subjects of intensive research and have important implications for global health. Indeed, although nearly all vaccines in use today depend on their ability to induce B cell memory, we have not yet succeeded in developing vaccines for some of the world’s most deadly diseases, including AIDS and malaria. Here, we describe the two-phase process by which antigen drives the generation of long-lived plasma cells and memory B cells and highlight the challenges for successful vaccine development in each phase. The authors discuss the formation of two main ‘walls’ of B cell memory to protect against pathogen reinfection. The first wall comprises high-affinity antibodies produced by long-lived plasma cells, while the second wall is formed by memory B cells." @default.
- W2995903145 created "2019-12-26" @default.
- W2995903145 creator A5045036217 @default.
- W2995903145 creator A5089020899 @default.
- W2995903145 date "2019-12-13" @default.
- W2995903145 modified "2023-10-17" @default.
- W2995903145 title "B cell memory: building two walls of protection against pathogens" @default.
- W2995903145 cites W1596510058 @default.
- W2995903145 cites W182140570 @default.
- W2995903145 cites W1877571168 @default.
- W2995903145 cites W1894593978 @default.
- W2995903145 cites W1920961497 @default.
- W2995903145 cites W1958005161 @default.
- W2995903145 cites W1965359430 @default.
- W2995903145 cites W1970058349 @default.
- W2995903145 cites W1973201987 @default.
- W2995903145 cites W1979059478 @default.
- W2995903145 cites W1982573460 @default.
- W2995903145 cites W1990174512 @default.
- W2995903145 cites W1991701295 @default.
- W2995903145 cites W1992949591 @default.
- W2995903145 cites W1994693508 @default.
- W2995903145 cites W2001751895 @default.
- W2995903145 cites W2013262178 @default.
- W2995903145 cites W2013973130 @default.
- W2995903145 cites W2018521012 @default.
- W2995903145 cites W2019206924 @default.
- W2995903145 cites W2019447967 @default.
- W2995903145 cites W2030329053 @default.
- W2995903145 cites W2030707267 @default.
- W2995903145 cites W2038453475 @default.
- W2995903145 cites W2045067923 @default.
- W2995903145 cites W2049398130 @default.
- W2995903145 cites W2053095572 @default.
- W2995903145 cites W2065906324 @default.
- W2995903145 cites W2074096962 @default.
- W2995903145 cites W2079338940 @default.
- W2995903145 cites W2079574749 @default.
- W2995903145 cites W2085465802 @default.
- W2995903145 cites W2096084302 @default.
- W2995903145 cites W2099136802 @default.
- W2995903145 cites W2104516199 @default.
- W2995903145 cites W2112040693 @default.
- W2995903145 cites W2123475341 @default.
- W2995903145 cites W2126295850 @default.
- W2995903145 cites W2136616777 @default.
- W2995903145 cites W2138071207 @default.
- W2995903145 cites W2144902263 @default.
- W2995903145 cites W2145227714 @default.
- W2995903145 cites W2146819767 @default.
- W2995903145 cites W2161784995 @default.
- W2995903145 cites W2168628444 @default.
- W2995903145 cites W2188526495 @default.
- W2995903145 cites W2223595141 @default.
- W2995903145 cites W2239291357 @default.
- W2995903145 cites W2346243632 @default.
- W2995903145 cites W2396908022 @default.
- W2995903145 cites W2518196601 @default.
- W2995903145 cites W2527013454 @default.
- W2995903145 cites W2594104586 @default.
- W2995903145 cites W2600929961 @default.
- W2995903145 cites W2612221206 @default.
- W2995903145 cites W2731449818 @default.
- W2995903145 cites W2735379097 @default.
- W2995903145 cites W2773878006 @default.
- W2995903145 cites W2777889365 @default.
- W2995903145 cites W2780290167 @default.
- W2995903145 cites W2783088490 @default.
- W2995903145 cites W2783532479 @default.
- W2995903145 cites W2786695043 @default.
- W2995903145 cites W2787240390 @default.
- W2995903145 cites W2793820661 @default.
- W2995903145 cites W2801474028 @default.
- W2995903145 cites W2801527373 @default.
- W2995903145 cites W2806609121 @default.
- W2995903145 cites W2807525444 @default.
- W2995903145 cites W2883231926 @default.
- W2995903145 cites W2887571512 @default.
- W2995903145 cites W2896276853 @default.
- W2995903145 cites W2897261190 @default.
- W2995903145 cites W2903023290 @default.
- W2995903145 cites W2921924623 @default.
- W2995903145 cites W2938678047 @default.
- W2995903145 cites W2946450286 @default.
- W2995903145 cites W2950500116 @default.
- W2995903145 cites W2955005578 @default.
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- W2995903145 doi "https://doi.org/10.1038/s41577-019-0244-2" @default.
- W2995903145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7223087" @default.
- W2995903145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31836872" @default.
- W2995903145 hasPublicationYear "2019" @default.
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